Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: A capsule monitoring system for an aerosol-generating device includes at least one processor and a memory. The memory is coupled to the at least one processor and storing instructions. The at least one processor is configured to execute the instructions to cause the capsule monitoring system to detect a mechanism detection switch of the aerosol-generating device being actuated, apply a first power to a first contact point of the aerosol-generating device, determine a first resistance between the first contact point and a second contact point, determine whether the first resistance is within a resistance operation range, and in response to the first resistance being within of the resistance operation range, display a capsule accepted indicator. The first contact point is configured to contact a heater. The second contact point is configured to contact the heater.

Abstract: A charging system for an aerosol-generating device includes a processor and a memory in communication with the processor and configured to store instructions is provided. The instructions define at least one of a disable mode, an intra-session mode, or an inter-session mode. The processor is configured to execute the instructions to cause the charging system to detect when the device is connected to a charging device; activate a power source charger in response to the connection to the charging device; identify a selected mode; enable or disable a heater of the capsule dependent upon the selected mode; if the heater is enabled, display a first display indicating the connection of the charging device; if the heater is enabled, detect if a session of the aerosol-generating device is ongoing; and if the session is ongoing, enable or suspend charging in response to the identification of the selected mode.

Abstract: A power control system for an aerosol-generating device includes at least one processor and a memory. The memory is coupled to the at least one processor and is configured to store instructions. The at least one processor is configured to execute the instructions to cause the power control system to determine whether a first power to be applied to a heater of the aerosol-generating device exceeds a power threshold, in response to the first power exceeding the power threshold, apply a second power to the heater, and in response to the first power not exceeding the power threshold, apply the first power to the heater. The first power is based on a desired heater temperature. The second power does not exceed the power threshold.

Abstract: A session control system for a device includes at least one processor and a memory coupled to the at least one processor. The memory is configured to store instructions. The at least one processor is configured to execute the instructions to cause the session control system to detect when a session has started, start a session timer, increment a puff variable when an airflow sensor detects that a puff has been taken, monitor the session timer against a time threshold and the puff variable against a puff threshold, and in response to a session threshold being met, end the session. The session timer is configured to measure a length of the session and the puff variable corresponds to a total number of puffs taken.

Abstract: A cooldown system for a device includes at least one processor and a memory coupled to the at least one processor. The memory is configured to store instructions. The at least one processor is configured to execute the instructions to cause the cooldown system to detect when a session has ended, activate a cooldown timer to measure a cooldown time, provide an indication of a remaining time of the cooldown timer, and in response to the cooldown timer elapsing, return the device to normal operation.

Abstract: The present invention relates to a process for the preparation of substituted 4-(N?-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

Abstract: A device for assisting surgery includes means for offsetting a rotation of a first type and a second type, a mechanism for transmitting a rotation of a third type, and a mechanism for transforming the rotation of a third type into a translation. An elastic element is connected at one end to the mechanism for transmitting the rotation of a third type. The mechanism for transmitting the rotation of a third type is connected to a rotary motor, the rotation of the motor in a first direction causing the lowering of a tool and an elongation of the elastic element, the rotation of the motor in a second direction causing the raising of the tool and a contraction of the elastic element, and, when the tool is lowered and the rotary motor is not exerting any torque, the elastic element returns to an initial shape causing the raising of the tool.

Abstract: A heat-not-burn (HNB) aerosol generating device may include a housing including a power supply and an air inlet, a mouthpiece assembly movably attached to the housing, and providing an air outlet, a door assembly moveably attached to the housing, the door assembly including a door and a receptacle movably attached to the door, the receptacle defining a cavity to receive a capsule including an aerosol generating substrate, and a linkage arrangement operationally connected to the door assembly, the mouthpiece assembly and the housing, and the linkage arrangement cooperatively moving the mouthpiece assembly and the receptacle in response to movement of the door to a closed state such that the capsule is retained within the housing and operationally connected with the power supply, the air inlet and the air outlet.

Abstract: The various embodiments described herein generally relate to systems and methods for monitoring an operation of one or more self-driving vehicles. The method involves operating a vehicle processor of a self-driving vehicle to: collect, during operation, operation data associated with the operation of the self-driving vehicle; detect, from the operation data, a trigger condition is satisfied during the operation; determine, for the trigger condition, a pre-condition period and a post-condition period, the pre-condition period defining a time period before the trigger condition occurred and the post-condition period defining a time period following the trigger condition; retrieve, from a vehicle data storage, the subset of the operation data collected by the self-driving vehicle during the pre-condition period and the post-condition period; and transmit the subset of the operation data to the data analysis system.

Abstract: A method of delivering content in one or more packets over a network is described. A content request packet comprising a request for content based on a first IPv6 address is received, the first IPv6 address identifying the content. The first IPv6 address is mapped to a second IPv6 address, the second IPv6 address being associated with the content at a physical location. The content requested in the content request packet is then received from the physical location associated with the second IPv6 address for delivery to a user. A further method includes routing a packet for requesting the content from a client to a content server storing an instant of the content, based on an IPv6 address of content being requested by the client. A communication session is then set up between the client and the content server; and the requested content is transmitted from the content server.

Abstract: Labyrinth seal for a turbine engine, in particular of an aircraft, including a rotor element rotating about an axis of rotation, and a stator element extending around the rotor element The rotor element includes a series of annular lips extending radially outwards and surrounded by at least one abradable element carried by the stator element. Each lip includes an inner peripheral body portion, an outer peripheral body portion and an upstream annular face for impact of an air flow during operation. At least one lip has, looking from the upstream annular face, a first annular cavity with a concave rounded cross-section on its inner peripheral body portion and a second annular cavity with a concave rounded cross-section on its outer peripheral body portion.

Abstract: A content delivery node receives data packets carrying content from an upstream source of content, and writes segments of the received content directly to a memory buffer of a memory using direct memory access (DMA) data transfers. The node derives, for each segment, respective segment-specific metadata based on contents of the segment, and stores the respective segment-specific metadata in the memory. The node receives from multiple downstream client devices respective requests for the same content. Each request includes client-specific information.

Abstract: A method of delivering content in one or more packets over a network is described. A content request packet comprising a request for content based on a first IPv6 address is received, the first IPv6 address identifying the content. The first IPv6 address is mapped to a second IPv6 address, the second IPv6 address being associated with the content at a physical location. The content requested in the content request packet is then received from the physical location associated with the second IPv6 address for delivery to a user. A further method includes routing a packet for requesting the content from a client to a content server storing an instant of the content, based on an IPv6 address of content being requested by the client. A communication session is then set up between the client and the content server; and the requested content is transmitted from the content server.

Abstract: A content delivery node receives data packets carrying content from an upstream source of content, and writes segments of the received content directly to a memory buffer of a memory using direct memory access (DMA) data transfers. The node derives, for each segment, respective segment-specific metadata based on contents of the segment, and stores the respective segment-specific metadata in the memory. The node receives from multiple downstream client devices respective requests for the same content. Each request includes client-specific information.

Abstract: Labyrinth seal for a turbine engine, in particular of an aircraft, including a rotor element rotating about an axis of rotation (A), and a stator element extending around the rotor element (14), the rotor element including a series of annular lip(s) extending radially outwards and surrounded by at least one abradable element carried by the stator element, each lip comprising an inner peripheral body portion, an outer peripheral body portion, an upstream annular face of impact of an air flow during operation and a downstream annular face, wherein at least one lip includes, on the inner peripheral body portion thereof and/or the outer peripheral body portion thereof, through-orifices for the passage of air extending between the upstream and downstream annular faces.

Abstract: Labyrinth seal for a turbine engine, in particular of an aircraft, including a rotor element rotating about an axis of rotation (A), and a stator element extending around the rotor element, the rotor element including a series of annular lip(s) extending radially outwards and surrounded by at least one abradable element carried by the stator element, each lip including an inner peripheral body portion, an outer peripheral body portion (12b) and an upstream annular face for impact of an air flow during operation, wherein at least one lip has, looking from the upstream annular face, a first annular cavity with a concave rounded cross-section on its inner peripheral body portion and a second annular cavity with a concave rounded cross-section on its outer peripheral body portion.

Abstract: A device for controlling clearance at the tops of turbine rotating blades. The device comprises shroud supporting rings, abradable ring sectors, elastic centering means, and a shroud supporting ring sectors inserted radially to the supporting shroud, between the elastic means and the abradable ring sectors, which are attached to said supporting shroud, which has a volume varying according to temperature, due to the action of fluid supply means.