Patents by Inventor Guillermo A. Altenberg

Guillermo A. Altenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer nanodiscs for biotechnology and medical applications
    Patent number: 11471411
    Abstract: The present invention includes compositions, methods, and methods of making and using a nanoscale discoidal membrane comprising: an amphiphilic membrane patch comprising self-assembled molecular amphiphiles capable of supporting one or more membrane proteins in the amphiphilic membrane patch; and one or more amphipathic scaffold macromolecules that encase the nanoscale discoidal membrane.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: October 18, 2022
    Assignee: Texas Tech University System
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • Polymer-encased nanodiscs with improved buffer compatibility
    Patent number: 11332555
    Abstract: The present invention includes compositions, methods, and methods of making and using a polymer-encased nanodisc comprising: one or more integral membrane proteins in a lipid layer; and a polymer comprising zwitterionic styrene-maleic acid derivative repeating units that carry zero or nearly zero negative charge, and the polymer-encased nanodiscs.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: May 17, 2022
    Assignee: Texas Tech University System
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • Polymer-Encased Nanodiscs With Improved Buffer Compatibility
    Publication number: 20210171673
    Abstract: The present invention includes compositions, methods, and methods of making and using a polymer-encased nanodisc comprising: one or more integral membrane proteins in a lipid layer; and a polymer comprising zwitterionic styrene-maleic acid derivative repeating units that carry zero or nearly zero negative charge, and the polymer-encased nanodiscs.
    Type: Application
    Filed: October 7, 2020
    Publication date: June 10, 2021
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • AMPHIPHILIC AMINOGLYCOSIDE CONNEXIN HEMICHANNEL INHIBITORS
    Publication number: 20210163521
    Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4?, O-6?, or O-4? and O-6? positions having reduced antimicrobial activity for targeting Connexin Hemichannels.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 3, 2021
    Inventors: Guillermo A. Altenberg, Cheng-Wei Tom Chang
  • Polymer-encased nanodiscs with improved buffer compatibility
    Patent number: 10829571
    Abstract: The present invention includes compositions, methods, and methods of making and using a polymer-encased nanodisc comprising: one or more integral membrane proteins in a lipid layer; and a polymer comprising zwitterionic styrene-maleic acid derivative repeating units that carry zero or nearly zero negative charge, and the polymer-encased nanodiscs.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: November 10, 2020
    Assignee: Texas Tech University System
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • Polymer Nanodiscs for Biotechnology and Medical Applications
    Publication number: 20200281855
    Abstract: The present invention includes compositions, methods, and methods of making and using a nanoscale discoidal membrane comprising: an amphiphilic membrane patch comprising self-assembled molecular amphiphiles capable of supporting one or more membrane proteins in the amphiphilic membrane patch; and one or more amphipathic scaffold macromolecules that encase the nanoscale discoidal membrane.
    Type: Application
    Filed: September 18, 2018
    Publication date: September 10, 2020
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • Polymer-Encased Nanodiscs With Improved Buffer Compatibility
    Publication number: 20190062469
    Abstract: The present invention includes compositions, methods, and methods of making and using a polymer-encased nanodisc comprising: one or more integral membrane proteins in a lipid layer; and a polymer comprising zwitterionic styrene-maleic acid derivative repeating units that carry zero or nearly zero negative charge, and the polymer-encased nanodiscs.
    Type: Application
    Filed: August 30, 2018
    Publication date: February 28, 2019
    Inventors: Guillermo A. Altenberg, Hongjun Liang