Patents by Inventor Guillermo Garcia-Manero

Guillermo Garcia-Manero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPIES
    Publication number: 20210100775
    Abstract: Provided herein are methods of treating and sensitizing cancer comprising administering a heterocyclic compound and a DNA hypomethylating agent.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 8, 2021
    Inventors: Daniel P. GOLD, Guillermo GARCIA-MANERO
  • Methods and Compositions for the Treatment of Myelodysplastic Syndrome
    Publication number: 20210009707
    Abstract: The present invention relates to methods for the treatment of Myelodysplastic Syndrome, in particular subjects who have been shown to be refractory or resistant to treatments such as treatments with hypomethylating agents. Also provided are compositions for use in the treatment of Myelodysplastic Syndrome, in particular subjects who have been shown to be refractory or resistant to treatments such as treatments with hypomethylating agents.
    Type: Application
    Filed: May 2, 2017
    Publication date: January 14, 2021
    Inventors: Mary Reilly, Robert Miller, Guillermo Garcia-Manero
  • COMBINATION THERAPIES
    Publication number: 20150258068
    Abstract: Provided herein are methods of treating a disease or disorder associated with dysregulation of histone deacetylase, and more specifically sensitizing and treating chemoresistant cancer comprising administering a therapeutically effective amount of a combination comprising a benzimidazole compound and a DNA hypomethylating agent and kits containing said combination. The preferred DNA hypomethylating agent used in the method is 5-azacitidine azacitidine.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 17, 2015
    Inventors: Daniel P. Gold, Guillermo Garcia-Manero
  • Methods of Identifying and Treating Individuals Exhibiting NUP214-ABL1 Positive T-Cell Malignancies with Protein Tyrosine Kinase Inhibitors and Combinations Thereof
    Publication number: 20110263609
    Abstract: The invention described herein relates to diagnostic and treatment methods and compositions useful in the management of disorders, for example cancers, involving NUP214-ABL1 positive T-cell malignancies and methods for treating an individual suffering from a NUP214-ABL1 positive T cell malignancy.
    Type: Application
    Filed: November 14, 2008
    Publication date: October 27, 2011
    Inventors: Alfonso Quintas-Cardama Lee, Guillermo Garcia-Manero