Patents by Inventor Guillermo Gerona-Navarro

Guillermo Gerona-Navarro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-thioether stapled peptides as inhibitors of PRC2 function
    Patent number: 11345725
    Abstract: This disclosure describes three novel bisthioether stapled peptides as allosteric inhibitors of Polycomb Repressive Complex 2 (PRC2) catalytic function with demonstrated cell permeability, potent activity in physiological conditions, and strong antiproliferative effects on cancer cells. These inhibitors target, for the first time, two protein interfaces in PRC2 that are crucial for its proper assembling and thus for its histone methyltransferase activity.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: May 31, 2022
    Assignee: Research Foundation of the City University of New York
    Inventors: Guillermo Gerona-Navarro, Gan Zhang, Flavia Barragan
  • BIS-THIOETHER STAPLED PEPTIDES AS INHIBITORS OF PRC2 FUNCTION
    Publication number: 20210079044
    Abstract: This disclosure describes three novel bisthioether stapled peptides as allosteric inhibitors of Polycomb Repressive Complex 2 (PRC2) catalytic function with demonstrated cell permeability, potent activity in physiological conditions, and strong antiproliferative effects on cancer cells. These inhibitors target, for the first time, two protein interfaces in PRC2 that are crucial for its proper assembling and thus for its histone methyltransferase activity.
    Type: Application
    Filed: September 16, 2020
    Publication date: March 18, 2021
    Inventors: Guillermo Gerona-Navarro, Gan Zhang, Flavia Barragan
  • Small molecule transcription modulators of bromodomains
    Patent number: 10065951
    Abstract: This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory diseases.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: September 4, 2018
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Ming-MIng Zhou, Guillermo Gerona-Navarro, Yoel Rodriguez-Fernandez, Patrizia Casaccia
  • Small Molecule Transcription Modulators of Bromodomains
    Publication number: 20170107218
    Abstract: This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory diseases.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 20, 2017
    Inventors: Ming-MIng Zhou, Guillermo Gerona-Navarro, Yoel Rodriguez-Fernandez, Patrizia Casaccia