Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract: Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through.

Abstract: The present disclosure provides a common-path optical waveguide probe. The common-path optical waveguide probe includes an optical waveguide, a lens, and a reference reflector. The optical waveguide includes a proximal end and a distal end. The lens is coupled to the distal end. The reference reflector is positioned between the optical waveguide and the lens. The disclosure also provides a catheter and an optical coherence tomography system utilizing the common-path optical waveguide probe. The disclosure also provides methods of making and using the common-path optical waveguide probe.

Abstract: Probes, catheters, systems, methods, and ferrofluids are provides for acquiring direct visualization medical images of internal structures. The probes can include a channel, an optical waveguide, and a ferrofluid attractor. The ferrofluid attractor can be configured to magnetically attract the ferrofluid when exiting a distal port of the channel The medical image can be acquired through the ferrofluid, which is excluding blood from the area that the ferrofluid is occupying. The ferrofluid has a lower optical absorbance than blood, so the acquiring the image through the ferrofluid rather than through blood provides improved images.

Abstract: Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance.

Abstract: In some embodiments, systems, methods, and media for capsule-based multimode endoscopy are provided. In some embodiments, a probe for capsule-based multimode endoscopy is provided, the probe comprising: a rigid capsule; a flexible tether coupled to a proximal end of the capsule; a rotatable reflective surface disposed within the capsule; a static ball lens disposed within the capsule; a first optical fiber optically coupled to the ball lens, the first optical fiber passing through the flexible tether; a second optical fiber optically coupled to the ball lens, the second optical fiber passing through the flexible tether; a graded index fiber disposed between a distal end of the second optical fiber and the ball lens, the graded index fiber optically coupled to the second optical fiber and the ball lens.

Abstract: Exemplary apparatus, systems, methods of making, and methods of using a rotary junction are provided. A rotary junction having multiple channels is provided herein. The rotary junction has a first coupling optic and a second coupling optic where the rotating optical fiber or other waveguide comping from the first coupling optic passes through the second coupling optics.

Abstract: Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through.

Abstract: Apparatus and method can be provided for obtaining at least one anatomical sample. For example, it is possible to provide and insert a housing into a body or provided on a hydrated anatomical structure. Further, with a source, it is possible to emit an electromagnetic radiation which causes at least the anatomical sample(s) to attach to at least one portion of the housing. A compound can be provided on a surface of the housing, and the source provides the radiation to the compound and changes properties thereof to be adhesive. The source can provide the radiation to the housing, and can change properties of a surface thereof to be adhesive. A component can be provided on a surface of the anatomical structure, and the source provides the radiation to the compound and changes properties thereof to be adhesive.

Abstract: Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract: A probe for performing endomicroscopy, including: a light source; a waveguide coupled to the light source; a diffraction grating, the waveguide directing light from the light source to the diffraction grating; and a lens having a first aspheric surface and a second biconic surface, diffracted light from the diffraction grating being directed into the aspheric surface of the lens and being emitted from the biconic surface of the lens towards a transparent cylindrical surface of the probe.

Abstract: Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance.

Abstract: In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled to the second coupler via an optical waveguide that induces a delay at least equal to an acquisition time of an image sensor; and an output coupled to the image sensor.

Abstract: An apparatus comprising at least: a first waveguide; a second waveguide; and a diffractive element. The first waveguide guides a first band of onto the diffractive element such that the first band is diffracted at an mth non-zero order over a first range of angles. The second waveguide guides a second band onto the diffractive element such that the second band is diffracted at the mth non-zero over the first range of angles. The second waveguide guides a third band onto the diffractive element such that the third band is diffracted at the nth non-zero order over the first range of angles. Wavelengths of the first band, the second band, and the third band do not overlap with each other. The mth order and the nth order are different from each other.

Abstract: Method and apparatus can be provided according to an exemplary embodiment of the present disclosure. For example, with at least one first section of an optical enclosure, it is possible to provide at least one first electro-magnetic radiation. In addition, with at least one second section provided within the enclosure, it is possible to cause, upon impact by the first radiation, a redirection of the first radiation to become at least one second radiation. Further, with at least one third section of the optical enclosure, it is possible to cause at least one second radiation to be provided to a tissue. For example, the redirection of the first radiation causes, at least approximately, a uniform optical illumination on of a surface of the tissue.

Abstract: An apparatus according to an exemplary embodiment of the present disclosure can include a first section(s) and a second section(s) which can have a cross-section that can be smaller than that of the first section. The first and second sections can be a particular section and can include memory-forming characteristics. An imaging arrangement can be in communication with the first section or the second section. The particular section can have a first shape when the particular section can be constrained, and the particular section can have a second shape when the particular section can be unconstrained. The second shape can be more curved than the first shape.

Abstract: In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

Abstract: Systems for providing an optical rotary joint are provided. In some embodiments, a system comprises: a lens-less optical rotary joint, comprising: a guide ferrule; a rotatable ferrule; a rotatable optical fiber, the rotatable optical fiber passing through the rotatable ferrule and the guide ferrule, the rotatable optical fiber being secured within the rotatable ferrule, and the rotatable optical fiber being freely rotatable within the guide ferrule; and a coupler to secure the guide ferrule and receive a static ferrule including a static optical fiber such that a face of the static optical fiber is proximate a face of the rotatable optical fiber.