Patents by Inventor Guillermo Madico

Guillermo Madico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for vaccinating a subject for a sexually transmitted pathogen
    Patent number: 9987346
    Abstract: Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method for vaccinating a subject against Chlamydia using a composition that is a recombinant Neisseria porin that contains at least one antigenic variable domain of Chlamydia. The variable domains are inserted into the amino acid sequence of the Neisseria porin at a position encoding a surface-exposed loop of the Neisseria porin. The vaccine further contains an adjuvant that induces a Th1 response greater than a Th2 response.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: June 5, 2018
    Assignees: Trustees of Tufts College, Boston Medical Center Corporation, The Regents of the University of California
    Inventors: Paola Massari, Guillermo Madico, Luis de la Maza
  • Methods and compositions for vaccinating a subject for a sexually transmitted pathogen
    Publication number: 20170252424
    Abstract: Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method for vaccinating a subject against Chlamydia using a composition that is a recombinant Neisseria porin that contains at least one antigenic variable domain of Chlamydia. The variable domains are inserted into the amino acid sequence of the Neisseria porin at a position encoding a surface-exposed loop of the Neisseria porin. The vaccine further contains an adjuvant that induces a Th1 response greater than a Th2 response.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Inventors: Paola Massari, Guillermo Madico, Luis de la Maza