Abstract: A method for computational drug target selection includes ingesting publication data from at least one publication data source, the publication data relating to a plurality of publication documents including historical publication documents and current publication documents. The method includes searching the publication data to provide an indication, for each of the publication documents, as to whether the respective publication document is associated with one or more drug targets. The method includes determining an expected publication parameter for each of the one or more drug targets based on the searched publication data from the historical publication documents, and determining an actual publication parameter for each of the one or more drug targets based on the searched publication data from the current publication documents. The method includes evaluating each of the one or more drug targets for selection based on its actual publication parameter relative to its expected publication parameter.