Abstract: A methionine adenosyltransferase (MAT) 2A inhibitor represented by formula (I), a preparation method thereof, a pharmaceutical composition comprising the same, and pharmaceutical use thereof are disclosed. The compound has excellent MAT2A inhibitory activity.

Abstract: The present disclosure provides a pharmaceutical composition for treating sepsis and use thereof, belonging to the technical field of chemical drugs. The present disclosure provides a three-component pharmaceutical composition including hydroxysafflower yellow A (HSYA), paeoniflorin, and albiflorin. The present disclosure further provides a seven-component pharmaceutical composition including HSYA, paeoniflorin, albiflorin, oxypaeoniflorin, senkyunolide I, salvianic acid A sodium (SAAS), and ferulic acid. In the present disclosure, it is verified at the cell level and the animal level that both two groups of the pharmaceutical compositions have an efficacy of effectively treating sepsis. Meanwhile, drug toxicity experiments show that the two groups of the pharmaceutical compositions both are safe. The pharmaceutical composition is an active ingredient of the Xuebijing Injection, which can be used for the clinical treatment of sepsis.

Abstract: The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower Carthamus, Red Paeony Root, Ligusticum wallichii, Radix salvia miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modem pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.

Abstract: Disclosed methods include sending, from a resource manager, network configuration information to each of one or more managed resources. The network configuration information may include an IP address for the resource manager, an IP address for each of the managed resources, and a predetermined timeout value. Network configurations for the resource manager and the one or more managed resources may then be set after which each managed resource may start a timer with the predetermined timeout value. If the resource manager detects successful completion of each of the network configuration operations, the resource manager may send a stop timer command to each of the managed resources. If a timeout occurs, the timeout will inform each of the managed resources that the change in network configuration was not entirely successful. The resource manager and each of the managed resources will then restore their network configurations to their previous configurations.

Abstract: Disclosed methods include sending, from a resource manager, network configuration information to each of one or more managed resources. The network configuration information may include an IP address for the resource manager, an IP address for each of the managed resources, and a predetermined timeout value. Network configurations for the resource manager and the one or more managed resources may then be set after which each managed resource may start a timer with the predetermined timeout value. If the resource manager detects successful completion of each of the network configuration operations, the resource manager may send a stop timer command to each of the managed resources. If a timeout occurs, the timeout will inform each of the managed resources that the change in network configuration was not entirely successful. The resource manager and each of the managed resources will then restore their network configurations to their previous configurations.

Abstract: A DC/DC converter includes a soft start overshoot prevention mechanism. The DC/DC converter includes a DC/DC conversion circuit, an overshoot detection apparatus, a pulse width modulation generator, an error amplifier, and an integration circuit connected to an output port of the error amplifier. The integration circuit is configured to perform integration processing on a difference between a reference voltage and an output voltage of the DC/DC conversion circuit, and control an amplitude of an amplified voltage that is input by the error amplifier to the pulse width modulation generator. The overshoot detection apparatus obtains an operating status parameter of the DC/DC converter, and controls, when the operating status parameter of the DC/DC converter meets an operating status parameter requirement, the integration circuit to discharge.

Abstract: A pin state configuration circuit, a method for configuring pin states and an electronic device for configuring pin states are provided. The pin state configuration circuit includes a configured resistor load, a voltage sampling unit, and a comparator. The voltage sampling unit supplies a reference voltage to the configured resistor load by using a first or second configuration pin, and respectively samples voltages of the first and second configuration pins. The comparator calculates a first voltage ratio based on the voltage of the first configuration pin and the voltage of the second configuration pin, calculates a second voltage ratio based on the voltage of the first configuration pin and the voltage of the second configuration pin, and determines a corresponding pin configuration state based on the first and second voltage ratios. In this way, N×N pin configuration states may be obtained by configuring two configuration pins.

Abstract: A pin state configuration circuit, a method for configuring pin states and an electronic device for configuring pin states are provided. The pin state configuration circuit includes a configured resistor load, a voltage sampling unit, and a comparator. The voltage sampling unit supplies a reference voltage to the configured resistor load by using a first or second configuration pin, and respectively samples voltages of the first and second configuration pins. The comparator calculates a first voltage ratio based on the voltage of the first configuration pin and the voltage of the second configuration pin, calculates a second voltage ratio based on the voltage of the first configuration pin and the voltage of the second configuration pin, and determines a corresponding pin configuration state based on the first and second voltage ratios. In this way, N×N pin configuration states may be obtained by configuring two configuration pins.

Abstract: The invention relates to a method for preparing nicotinamide mononucleotide by using nicotinamide as a raw material, which comprises: in acetonitrile, dichloromethane, 1,2-dichloroethane or liquid sulfur dioxide as a solvent, allowing nicotinamide and tetraacetyl ribose to react as catalyzed by trimethylsilyl trifluoromethanesulfonate or tin tetrachloride, adjusting a pH value thereof to 3-5, adding a sodium methoxide solution thereto to react at ?15° C. to 5° C., adjusting a pH value thereof to 3-5, and subjecting the reaction mixture to microfiltration and nanofiltration using a membrane concentrator, thereby obtain a nicotinamide ribose solution; allowing the nicotinamide ribose solution to react as catalyzed by nicotinamide ribokinase in the presence of Mg ions, ATP and a buffer, thereby obtaining nicotinamide mononucleotide.

Abstract: A DC/DC converter includes a soft start overshoot prevention mechanism. The DC/DC converter includes a DC/DC conversion circuit, an overshoot detection apparatus, a pulse width modulation generator, an error amplifier, and an integration circuit connected to an output port of the error amplifier. The integration circuit is configured to perform integration processing on a difference between a reference voltage and an output voltage of the DC/DC conversion circuit, and control an amplitude of an amplified voltage that is input by the error amplifier to the pulse width modulation generator. The overshoot detection apparatus obtains an operating status parameter of the DC/DC converter, and controls, when the operating status parameter of the DC/DC converter meets an operating status parameter requirement, the integration circuit to discharge.

Abstract: The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower Carthamus, Red Paeony Root, Ligusticum wallichii, radix salvia miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modem pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.

Abstract: The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower carthamus. Red Paeony Root, Ligusticum wallichii, radix salviae miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modern pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.

Abstract: The invention discloses a high-capacity cylindrical lithium ion battery. Tab-position end face is shaped; a high frequency oscillation and pressure are applied on to make the foil bodies softened in the scope of 0.1-6.5 mm. At the instant of high-frequency oscillation, the rigidity of the foil body is greatly decreased; and the foil bodies are mutually wound and compressed together, so that the weight density of the foil body in unit volume is increased and meanwhile, the rigidity of the compressed foil body at the Tab-position end face is greatly increased, thereby laying a firm foundation for laser welding of the 1 Tab-position end face and a current collector, increasing a laser welding effective area of the Tab-position end face and the current collector, and improving the welding strength.

Abstract: A curved battery and manufacturing method thereof, includes the following steps: electroplating an electrode sheet, rolling said electrode sheet along its long side, first sealing, heating, pouring in electrolyte fluid, charging, vacuuming, second sealing, and shaping. Wherein, the electrode sheet is of a long strip shape, with its outside wrapped with separation film, to separate the positive electrode and negative electrode. While perform rolling, it is performed along its long side, to remove the stress that may occur after the product is produced. Then, sealing is performed by using films made of water resistant and heat resistant material for sealing at least three side edges. Pour in electrolyte fluid of LiPF6 in an overall temperature of 75 degrees. Afterwards, charging the electrolyte fluid, perform vacuuming, and perform second sealing. Finally, using heated tools to bend the half-finished battery into shape, to form a curved battery having uniform curvature.

Abstract: The invention discloses a high-capacity cylindrical lithium ion battery. Tab-position end face is shaped; a high frequency oscillation and pressure are applied on to make the foil bodies softened in the scope of 0.1-6.5 mm. At the instant of high-frequency oscillation, the rigidity of the foil body is greatly decreased; and the foil bodies are mutually wound and compressed together, so that the weight density of the foil body in unit volume is increased and meanwhile, the rigidity of the compressed foil body at the Tab-position end face is greatly increased, thereby laying a firm foundation for laser welding of the 1 Tab-position end face and a current collector, increasing a laser welding effective area of the Tab-position end face and the current collector, and improving the welding strength.

Abstract: A Modified Lithium Ion Polymer Battery, comprising multiple positive electrode sheets and multiple negative electrode sheets formed by blending binder with positive or negative electrode powder, respectively, and then coating or rolling with resulting mixture over copper foil or aluminum foil. Binder can be prepared from the following three components: (a) 0.1 wt %˜95 wt % of polyvinylidene fluoride, (b) 0.1 wt %˜90 wt % of amodified polyacrylates, (c) 0.1 wt %˜85 wt % of a modified polyethylene or polydienes, and choosing one or any two from them mixing in a proper ratio. The invention still provides a separation membrane, which is a non-porous polyalkylene oxide film, or a film made by coating a blend of polyalkylene oxide and polyvinylidene fluoride (PVDF), or a micro-porous polypropylene film, or a three-layered composite film of polypropylene, polyethylene and polypropylene.

Abstract: A modified lithium ion polymer battery, comprising a positive electrode sheet and a negative electrode sheet, formed by blending a binder with positive electrode powder and coating the resulting blend on a copper foil or an aluminum foil used as the collector, wherein said binder can be prepared from the following three components: (a) 0.1 wt %˜95 wt % of polyvinylidene fluoride; (b) 0.1 wt %˜90 wt % of a modified polyacrylates; and (c) 0.