Patents by Inventor Guixue Yu

Guixue Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 8557841
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: October 15, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES
    Publication number: 20120252799
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Application
    Filed: June 11, 2012
    Publication date: October 4, 2012
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 8232291
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: July 31, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic Aromatic Compounds Useful As Growth Hormone Secretagogues
    Publication number: 20110224199
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Application
    Filed: May 20, 2011
    Publication date: September 15, 2011
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 7977353
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: July 12, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 7910601
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: March 22, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic Aromatic Compounds Useful As Growth Hormone Secretagogues
    Publication number: 20100305114
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Application
    Filed: August 9, 2010
    Publication date: December 2, 2010
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Azabicyclic heterocycles as cannabinoid receptor modulators
    Patent number: 7816357
    Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I. including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R4, R5, m and n are described herein.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: October 19, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, William R. Ewing, Amarendra B. Mikkilineni, Annapurna Pendri, Bruce A. Ellsworth, Philip M. Sher, Samuel Gerritz, Chongqing Sun, Natesan Murugesan, Ximao Wu
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 7799801
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: September 21, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic Aromatic Compounds Useful As Growth Hormone Secretagogues
    Publication number: 20100016233
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Application
    Filed: July 22, 2009
    Publication date: January 21, 2010
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic Aromatic Compounds Useful As Growth Hormone Secretagogues
    Publication number: 20090324625
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Application
    Filed: September 3, 2009
    Publication date: December 31, 2009
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 7592354
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 22, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 7589102
    Abstract: Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1?, R2, R3, R4, Xa, Y, Z and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 15, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, Jun Li, William R. Ewing, Richard B. Sulsky, James J. Li, Joseph Anthony Tino
  • Quinoline inhibitors of cGMP phosphodiesterase
    Patent number: 7384958
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: June 10, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yingzhi Bi, Guixue Yu, David P. Rotella, John E. Macor
  • Azabicyclic heterocycles as cannabinoid receptor modulators
    Patent number: 7378418
    Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 27, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, William R. Ewing, Amarendra B. Mikkilineni, Annapurna Pendri, Philip M. Sher, Samuel Gerritz, Bruce A. Ellsworth, Gang Wu, Yanting Huang, Chongqing Sun, Natesan Murugesan, Zhengxiang Gu, Ying Wang, Doree Sitkoff, Stephen R. Johnson, Ximao Wu
  • Quinoline inhibitors of cGMP phosphodiesterase
    Patent number: 7378430
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: May 27, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yingzhi Bi, Guixue Yu, David P. Rotella, John E. Macor
  • Bicyclic heterocycles as cannabinoind-1 receptor modulators
    Patent number: 7317012
    Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formulas I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formulas: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein B, R1, R2, R3 and x are described herein.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: January 8, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chongqing Sun, Yanting Huang, Doree F. Sitkoff, Guixue Yu, Amarendra Mikkilineni, William R. Ewing
  • Quinoline Inhibitors of cGMP Phosphodiesterase
    Publication number: 20070155788
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Inventors: Yingzhi Bi, Guixue Yu, David Rotella, John Macor
  • Quinoline Inhibitors of cGMP Phosphodiesterase
    Publication number: 20070155775
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Inventors: Yingzhi Bi, Guixue Yu, David Rotella, John Macor
  • Quinoline inhibitors of cGMP phosphodiesterase
    Publication number: 20070117843
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 24, 2007
    Inventors: Yingzhi Bi, Guixue Yu, David Rotella, John Macor