Abstract: Provided herein are antibodies, masked antibodies (e.g., activatable antibodies), and antigen-binding fragments that target human CD47, polynucleotides encoding the same, therapeutic compositions thereof, and their use to treat CD47-positive diseases such as cancer. The masked antibodies described herein may comprise an IgG1 Fc region.

Abstract: Provided herein are anti-cluster of differentiation 40 (CD40) monoclonal antibodies, as well as conditionally-active variants thereof; and therapeutic and diagnostic methods of using said anti-CD40 monoclonal antibodies.

Abstract: Anti-4-1BB and anti-PD-1 binding proteins, as well as bispecific anti-4-1BB/anti-PD-1 binding proteins, including conditionally-active derivatives thereof, are provided. Therapeutic and diagnostic methods of using binding proteins are provided.

Abstract: The present disclosure provides antibodies that bind to the T-cell co-inhibitor ligand programmed death-ligand1 (PD-L1) protein, and methods of use. In various embodiments of the disclosure, the antibodies are fully human antibodies that bind to PD-L1. In certain embodiments, the present disclosure provides multi-specific antigen-binding molecules comprising a first binding specificity that binds to PD-L1 and a second binding specificity that binds to a tumor cell antigen, an infected cell-specific antigen, or a T-cell co-inhibitor. In some embodiments, the antibodies of the disclosure are useful for inhibiting or neutralizing PD-L1 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection.

Abstract: The present disclosure discloses a preparation method of a powder metallurgy (PM) superalloy with high strength and plasticity. Under the multi-field coupling action of a thermal field and a force field, the PM superalloy is obtained in a high-temperature graphite mold by using the method of conducting heat preservation and oscillating-pressure sintering in two steps. Under the action of a circulating pressure, rearrangement of powders and discharge of pores are promoted, and therefore, the PM superalloy is sintered and formed. The present disclosure further discloses a PM superalloy prepared by using the method above. The PM superalloy has the characteristics of low grade of prior particle boundary defects, uniform grain refinement and high density. The sintered PM superalloy obtained in the present disclosure has a yield strength of 955 MPa, a tensile strength of 1,437 MPa and an elongation of 31.9%, and has high strength and plasticity.

Abstract: The present disclosure provides a hybrid electric vehicle, a drive control method and a drive control device of a hybrid electric vehicle. The drive control method includes: obtaining a current gear position of the hybrid electric vehicle and a current electric charge level of a power battery; determining whether the vehicle is within a speed start-stop interval according to the current gear position of the hybrid electric vehicle and the current electric charge level of the power battery; obtaining a slope of a road on which the vehicle is driving and a current speed of the hybrid electric vehicle, if the vehicle is within a speed start-stop interval; and controlling a working state of an engine and/or a motor of the hybrid electric vehicle according to the slope of the road on which the vehicle is driving and the current speed of the vehicle.

Abstract: The present disclosure provides a hybrid electric vehicle, a drive control method and a drive control device of a hybrid electric vehicle. The drive control method includes: obtaining a current gear position of the hybrid electric vehicle and a current electric charge level of a power battery; determining whether the vehicle is within a speed start-stop interval according to the current gear position of the hybrid electric vehicle and the current electric charge level of the power battery; obtaining a slope of a road on which the vehicle is driving and a current speed of the hybrid electric vehicle, if the vehicle is within a speed start-stop interval; and controlling a working state of an engine and/or a motor of the hybrid electric vehicle according to the slope of the road on which the vehicle is driving and the current speed of the vehicle.