Patents by Inventor Gulilat Gebeyehu

Gulilat Gebeyehu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Agents for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 12065665
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: August 20, 2024
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 12043639
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: July 23, 2024
    Assignee: Molecular Transfer, Inc.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Transfection complexes and methods of using the same
    Patent number: 12037600
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: July 16, 2024
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • PLANT VIRUS MOVEMENT PROTEINS AND METHODS OF USING SAME
    Publication number: 20240209390
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Application
    Filed: November 29, 2023
    Publication date: June 27, 2024
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Plant virus movement proteins and methods of using same
    Patent number: 11866723
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: January 9, 2024
    Assignee: MOLECULAR TRANSFER INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • TRANSFECTION COMPLEXES AND METHODS OF USING THE SAME
    Publication number: 20220090141
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Application
    Filed: August 9, 2021
    Publication date: March 24, 2022
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • POL YCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
    Publication number: 20210323984
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: April 5, 2021
    Publication date: October 21, 2021
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • Transfection complexes and methods of using the same
    Patent number: 11085056
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: August 10, 2021
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
    Publication number: 20210189433
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 24, 2021
    Inventors: Joel JESSEE, Gulilat GEBEYEHU
  • Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 10968240
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: April 6, 2021
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Agents for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 10883118
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: January 5, 2021
    Assignee: Molecular Transfer Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • PLANT VIRUS MOVEMENT PROTEINS AND METHODS OF USING SAME
    Publication number: 20200283795
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Application
    Filed: January 20, 2020
    Publication date: September 10, 2020
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • Plant virus movement proteins and methods of using the same
    Patent number: 10538784
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 21, 2020
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • POLYCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
    Publication number: 20190352316
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: December 17, 2018
    Publication date: November 21, 2019
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
    Publication number: 20190264230
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: November 21, 2018
    Publication date: August 29, 2019
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS
    Publication number: 20190024167
    Abstract: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.
    Type: Application
    Filed: June 28, 2018
    Publication date: January 24, 2019
    Inventors: Irina Nazarenko, Ayoub Rashtchian, Joseph Solus, Richard M. Pires, Marlene Darfler, Gulilat Gebeyehu, Mekbib Astatke
  • Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 10155780
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 18, 2018
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • TRANSFECTION COMPLEXES AND METHODS OF USING THE SAME
    Publication number: 20180340188
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Application
    Filed: August 26, 2016
    Publication date: November 29, 2018
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat GEBEYEHU, Joel JESSE
  • Agents for improved delivery of nucleic acids to eukaryotic cells
    Patent number: 10138497
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 27, 2018
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Primers and methods for the detection and discrimination of nucleic acids
    Patent number: 10041117
    Abstract: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 7, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Irina Nazarenko, Ayoub Rashtchian, Joseph Solus, Richard M. Pires, Marlene Darfler, Gulilat Gebeyehu, Mekbib Astatke