Patents by Inventor Gun-Hyu BAE

Gun-Hyu BAE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11859169
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: January 2, 2024
    Assignee: Korea University Research and Business Foundation
    Inventors: Hee-Min Kang, Chandra Khatua, Gun-Hyu Bae, Hyo-Jun Choi, Sun-Hong Min
  • Patent number: 11828719
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: November 28, 2023
    Assignee: Korea University Research and Business Foundation
    Inventors: Hee-Min Kang, Chandra Khatua, Gun-Hyu Bae, Hyo-Jun Choi, Sun-Hong Min
  • Publication number: 20230330005
    Abstract: Disclosed is a self-assembled complex containing a calcium ion that includes a calcium ion; and at least one ligand, where the calcium ion and the ligand participate in a reversibly self-assembly or self-disassembly. The shape of the self-assembled complex varies depending on the type of the ligand, or the mixing ratio of the ligand when there are a plurality of ligands.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Sung-Gue LEE, Na-Yeon KANG, Yu-Ri KIM, Gun-Hyu BAE, Da-Hee KIM, Seong-Yeol KIM
  • Publication number: 20230330232
    Abstract: Disclosed is a self-assembled complex containing an iron ion that includes an iron ion; and at least one ligand, where the iron ion and the ligand are reversibly self-assembled or self-disassembled. The iron ion and the ligand are self-assembled to form an assembly structure at least part of which is round shaped.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Yu-Ri KIM, Gun-Hyu BAE, Sung-Gue LEE, Na-Yeon KANG, Sun-Hong MIN, Seong-Yeol KIM
  • Publication number: 20230324326
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
    Type: Application
    Filed: June 21, 2023
    Publication date: October 12, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Hee-Min KANG, Chandra Khatua, Gun-Hyu Bae, Hyo-Jun Choi, Sun-Hong Min
  • Publication number: 20230241214
    Abstract: Discloses is a technology of collecting a biological sample, delivering a substance into a living body, and regulating macrophage adhesion and polarization, by controlling a self-assembled complex and a nanosystem including the same by irradiation with light.
    Type: Application
    Filed: May 27, 2022
    Publication date: August 3, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin Kang, Yuri Kim, Gun-Hyu Bae, Sung-Gue Lee, Na-Yeon Kang
  • Publication number: 20230210992
    Abstract: The present invention relates to a nanosatellite-substrate complex capable of regulating stem cell adhesion and differentiation, and a method for preparing the same. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation by applying a magnetic field to the nanosatellite-substrate complex.
    Type: Application
    Filed: June 9, 2022
    Publication date: July 6, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Young-Keun KIM, Heemin KANG, THOMAS MYEONGSEOK KOO, Myeong-Soo KIM, Sung-Gue LEE, Gun-Hyu BAE
  • Publication number: 20230149605
    Abstract: The present invention relates to a nanobarrier for regulating macrophage adhesion and polarization. Moreover, the present invention relates to a method of regulating macrophage adhesion and polarization using the nanobarrier. According to the nanobarrier of the present invention and the method of regulating macrophage adhesion and polarization using the same, it is possible to efficiently regulate macrophage adhesion and polarization by applying a magnetic field to the nanobarrier.
    Type: Application
    Filed: October 11, 2022
    Publication date: May 18, 2023
    Applicants: Korea University Research and Business Foundation, Industry-University Cooperation Foundation Hanyang University ERICA Campus
    Inventors: Heemin KANG, Do-Kyoon KIM, Yu-Ri KIM, Gun-Hyu BAE
  • Publication number: 20220111059
    Abstract: The present invention relates to an effective component delivery system using self-assembly and self-disassembly of a self-assembled complex, and the effective component delivery system uses a self-assembled complex which is composed of substances existing in the body, thereby being less toxic and harmless to the human body, and the effective component delivery system is capable of controlling a self-disassembly rate and an effective component release rate by using various kinds of metal ions and ligands including phosphate or phosphonate.
    Type: Application
    Filed: April 19, 2021
    Publication date: April 14, 2022
    Applicant: Korea University Research and Business Foundation
    Inventors: HeeMin KANG, Gun Hyu BAE, Ramar THANGAM
  • Publication number: 20210269773
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 2, 2021
    Applicant: Korea University Research and Business Foundation
    Inventors: Hee-Min KANG, Chandra KHATUA, Gun-Hyu BAE, Hyo-Jun CHOI, Sun-Hong MIN
  • Publication number: 20210270765
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 2, 2021
    Applicant: Korea University Research and Business Foundation
    Inventors: Hee-Min KANG, Chandra KHATUA, Gun-Hyu BAE, Hyo-Jun CHOI, Sun-Hong MIN