Patents by Inventor Guna Romancik

Guna Romancik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • D-hydantoinase from Ochrobactrum anthropi
    Patent number: 6800465
    Abstract: The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: October 5, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Politino, Sean M. Tonzi, Guna Romancik, John J. Usher, David A. Lowe
  • Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
    Publication number: 20030044884
    Abstract: Disclosed is a process for the synthesis of &bgr;-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
    Type: Application
    Filed: October 4, 2002
    Publication date: March 6, 2003
    Inventors: John J. Usher, Guna Romancik
  • D-hydantoinase from Ochrobactrum anthropi
    Publication number: 20030013102
    Abstract: The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
    Type: Application
    Filed: April 3, 2002
    Publication date: January 16, 2003
    Inventors: Michael Politino, Sean M. Tonzi, Guna Romancik, John J. Usher, David A. Lowe
  • Synthesis of .beta.-lactam antibacterials using soluble side chain esters and enzyme acylase
    Patent number: 6156534
    Abstract: Disclosed is a process for the synthesis of .beta.-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: December 5, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Usher, Guna Romancik
  • Precursors of .beta.-lactam antibacterials having soluble side chain esters
    Patent number: 5922907
    Abstract: Disclosed is a process for the synthesis of .beta.-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: July 13, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John J. Usher, Guna Romancik
  • Chemical acetylation of desacetyl-cephalosporins
    Patent number: 5917032
    Abstract: The present invention is concerned with a chemical acetylation process for the preparation of 3'-acetylated cephalosporin from desacetyl-cephalosporin. The novel process is carried out with an acetyl donor and an activator or catalyst.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: June 29, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guna Romancik, John J. Usher
  • Cephalosporin esterase gene from Rhodosporidium toruloides
    Patent number: 5869309
    Abstract: The instant invention provides nucleic acid molecules encoding cephalosporin esterase from Rhodosporidium toruloides. In addition, the invention provides isolated cephalosporin esterase, expression vectors, host cells, and methods of producing cephalosporin esterase.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michael Politino, Sean M. Tonzi, John J. Usher, William V. Burnett, Guna Romancik
  • Enzymatic acylation of 3-hydroxymethyl cephalosporins
    Patent number: 5512454
    Abstract: O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: April 30, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Usher, Guna Romancik, Michael Politino, David A. Lowe
  • Production of cephalosporin C
    Patent number: 4520101
    Abstract: Production of undesired desacetylcephalosporin C during fermentation of cephalosporin C-producing microorganisms is substantially reduced by addition of certain phosphorous compounds to the culture medium.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: May 28, 1985
    Assignee: Bristol-Myers Company
    Inventors: David A. Lowe, Guna Romancik, Leonardo M. Cappelletti, Richard P. Elander