Patents by Inventor Gunars E. Valkirs

Gunars E. Valkirs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110065210
    Abstract: The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 17, 2011
    Inventors: Jeffrey R. Dahlen, Kenneth F. Buechler, Gunars E. Valkirs
  • Patent number: 7655428
    Abstract: The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: February 2, 2010
    Assignee: Biosite, Inc.
    Inventors: Gunars E. Valkirs, Joseph A. Buechler, Seok-Won Lee, Uday Kumar Veeramallu
  • Patent number: 7632647
    Abstract: The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: December 15, 2009
    Assignee: Biosite Incorporated
    Inventors: Jeffrey R. Dahlen, Kenneth F. Buechler, Gunars E. Valkirs
  • Patent number: 7608406
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: October 27, 2009
    Assignee: Biosite, Inc.
    Inventors: Gunars E. Valkirs, Jeffrey R. Dahlen, Howard J. Kirchick, Kenneth F. Buechler
  • Patent number: 7427490
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: September 23, 2008
    Assignee: Biosite Incorporated
    Inventors: Gunars E. Valkirs, Jeffrey R. Dahlen, Howard J. Kirchick, Kenneth F. Buechler
  • Patent number: 7052858
    Abstract: This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and kits that are useful for diagnosing infection by Cryptosporidium parvum. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the protein disulfide isomerase polypeptide of C. parvum.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: May 30, 2006
    Assignee: BIOSITE Incorporated
    Inventors: Jeff Gray, Gunars E. Valkirs, Joe Buechler
  • Patent number: 6908739
    Abstract: This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the ?-1-giardin antigen of G. lamblia.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: June 21, 2005
    Assignee: Biosite Incorporated
    Inventors: Joe Buechler, Shanthi Govindaraj, Jeff Gray, Gunars E. Valkirs
  • Patent number: 6828110
    Abstract: This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: December 7, 2004
    Assignee: Biosite Incorporated
    Inventors: Bruce A. Lee, Becky Mar Flores, Gunars E. Valkirs
  • Publication number: 20040219509
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Application
    Filed: November 14, 2003
    Publication date: November 4, 2004
    Applicant: Biosite, Inc.
    Inventors: Gunars E. Valkirs, Jeffrey R. Dahlen, Howard J. Kirchick, Kenneth F. Buechler
  • Publication number: 20040170967
    Abstract: This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis.
    Type: Application
    Filed: January 4, 2001
    Publication date: September 2, 2004
    Inventors: Bruce A. Lee, Becky Mar Flores, Gunars E. Valkirs
  • Publication number: 20040171064
    Abstract: The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
    Type: Application
    Filed: March 13, 2003
    Publication date: September 2, 2004
    Applicant: Biosite Incorporated
    Inventors: Jeffrey R. Dahlen, Kenneth F. Buechler, Gunars E. Valkirs
  • Patent number: 6777190
    Abstract: Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample. The assay includes the steps of providing at least one crosstalk inhibitor. This inhibitor, under assay conditions, competes with the linkage site of the ligand analogue conjugate for binding to the ligand receptor, and does not compete with the binding site of the ligand analogue conjugate for binding to the ligand receptor. In the invention, the assay is performed for the target ligand in the presence of a sufficient amount of the crosstalk inhibitor to reduce the amount of binding of the linkage site of the ligand analogue conjugate to the ligand receptor. The invention also features a method for identifying crosstalk inhibitors, and the crosstalk inhibitors themselves.
    Type: Grant
    Filed: May 11, 1994
    Date of Patent: August 17, 2004
    Assignee: Biosite, Inc.
    Inventors: Kenneth F. Buechler, Richard R. Anderson, Theodore T. Lee, Gunars E. Valkirs
  • Publication number: 20040096454
    Abstract: This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and kits that are useful for diagnosing infection by Cryptosporidium parvum. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the protein disulfide isomerase polypeptide of C. parvum.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 20, 2004
    Applicant: Biosite Diagnostics, a Delaware corporation
    Inventors: Jeff Gray, Gunars E. Valkirs, Joe Buechler
  • Publication number: 20030199000
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Application
    Filed: February 20, 2003
    Publication date: October 23, 2003
    Inventors: Gunars E. Valkirs, Jeffery Dahlen, Howard J. Kirchick, Kenneth F. Buechler
  • Publication number: 20030119064
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Application
    Filed: August 20, 2002
    Publication date: June 26, 2003
    Inventors: Gunars E. Valkirs, Jeffrey R. Dahlen, Howard J. Kirchick, Kenneth F. Buechler
  • Publication number: 20030064417
    Abstract: This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the &agr;-1-giardin antigen of G. lamblia.
    Type: Application
    Filed: May 23, 2002
    Publication date: April 3, 2003
    Applicant: Biosite Diagnostics, a Delaware corporation
    Inventors: Joe Buechler, Shanthi Govindaraj, Jeff Gray, Gunars E. Valkirs
  • Publication number: 20030022235
    Abstract: The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
    Type: Application
    Filed: April 13, 2001
    Publication date: January 30, 2003
    Inventors: Jeffrey R. Dahlen, Kenneth F. Buechler, Gunars E. Valkirs
  • Patent number: 6503722
    Abstract: This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile detection that involve assaying for both C. difficile glutamate dehydrogenase and C. difficile toxin A or toxin B. In another embodiment, the invention provides a highly sensitive assay for C. difficile toxin A that is useful for determining whether a C. difficile strain is toxigenic. This embodiment involves binding of toxin A to a moiety that reversibly binds to a capture moiety present on a magnetic bead. A magnetic field is applied to the sample to concentrate the toxin A, after which the magnetic beads are dissociated and removed from the solution to obtain a highly concentrated preparation of toxin A, thus making possible a very sensitive assay.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: January 7, 2003
    Assignee: Biosite Diagnostics
    Inventor: Gunars E. Valkirs
  • Publication number: 20020127618
    Abstract: This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The inventionalso provides methods, reagents, and kits that are useful for diagnosing infection by Cryptosporidium parvum. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the protein disulfide isomerase polypeptide of C. parvum.
    Type: Application
    Filed: September 21, 1998
    Publication date: September 12, 2002
    Inventors: JEFF GRAY, GUNARS E. VALKIRS, JOE BUECHLER
  • Patent number: 6348318
    Abstract: This invention provides methods, compositions and kits for concentrating target ligands, including microorganisms, from samples, including biological samples. The methods involve the use of magnetic particles to concentrate the target analytes. Also provided are methods, compositions and kits for detecting the presence of target ligands in samples.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: February 19, 2002
    Assignee: Biosite Diagnostics
    Inventor: Gunars E. Valkirs