Patents by Inventor Gunasekaran Kannan

Gunasekaran Kannan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) POLYPEPTIDES
    Publication number: 20140378665
    Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
    Type: Application
    Filed: January 28, 2013
    Publication date: December 25, 2014
    Inventors: Yumei Xiong, Yi Zhang, Jackie Zeqi Sheng, Agnes Eva Hamburger, Murielle Veniant-Ellison, Grant Shimamoto, Xiaoshan Min, Zhulun Wang, Jie Tang, Gunasekaran Kannan, Kenneth W. Walker, Bryan Lemon
  • INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
    Publication number: 20140343252
    Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
    Type: Application
    Filed: March 13, 2014
    Publication date: November 20, 2014
    Applicant: Amgen Inc.
    Inventors: Marc A. GAVIN, Gunasekaran KANNAN, Li LI, Joshua T. PEARSON, Margaret KAROW
  • PROTEINS SPECIFIC FOR BAFF AND B7RP1
    Publication number: 20140302036
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 9, 2014
    Applicant: Amgen Inc.
    Inventors: Hailing HSU, Ming ZHANG, Gunasekaran KANNAN, Frederick W. JACOBSEN, Wayne TSUJI
  • INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
    Publication number: 20140286898
    Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 25, 2014
    Applicant: Amgen Inc.
    Inventors: Marc A. GAVIN, Gunasekaran KANNAN, Li LI, Joshua T. PEARSON, Margaret KAROW
  • BCMA ANTIGEN BINDING PROTEINS
    Publication number: 20140161828
    Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 12, 2014
    Applicant: AMGEN INC.
    Inventors: Richard J. ARMITAGE, Michelle BLAKE, William C. FANSLOW, III, Jason Charles O'NEILL, Gunasekaran KANNAN, Jiangchun XU, Mark Edward TOMETSKO
  • HETERODIMERIC IMMUNOGLOBULINS
    Publication number: 20140154254
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 5, 2014
    Applicant: AMGEN INC.
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • Fc VARIANTS
    Publication number: 20140112926
    Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.
    Type: Application
    Filed: March 15, 2012
    Publication date: April 24, 2014
    Applicant: AMGEN INC.
    Inventors: Zhi Liu, Gunasekaran Kannan, Wei Yan
  • METHOD OF CORRELATED MUTATIONAL ANALYSIS TO IMPROVE THERAPEUTIC ANTIBODIES
    Publication number: 20140038285
    Abstract: A method of improving antibody manufacturability or developability through a computational approach.
    Type: Application
    Filed: March 9, 2012
    Publication date: February 6, 2014
    Applicant: AMGEN INC.
    Inventor: Gunasekaran Kannan
  • HOST CELL FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS
    Publication number: 20140024111
    Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: AMGEN INC.
    Inventors: Gunasekaran KANNAN, Michael WITTEKIND, Wei YAN, Martin J. PENTONY
  • Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
    Patent number: 8592562
    Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer. Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: November 26, 2013
    Assignee: Amgen Inc.
    Inventors: Gunasekaran Kannan, Michael Wittekind, Wei Yan, Martin Pentony
  • HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING BETA-KLOTHO AND AN FGF RECEPTOR
    Publication number: 20120328616
    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling.
    Type: Application
    Filed: June 1, 2012
    Publication date: December 27, 2012
    Applicant: AMGEN INC.
    Inventors: YANG LI, Jennitte STEVENS, Chadwick Terence KING, Ian FOLTZ, Gunasekaran KANNAN, Junming YIE, Shaw-Fen Sylvia HU
  • MONOMERIC ANTIBODY FC
    Publication number: 20120244578
    Abstract: The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
    Type: Application
    Filed: November 22, 2010
    Publication date: September 27, 2012
    Applicant: AMGEN INC.
    Inventors: Gunasekaran Kannan, Hongxing Zhou, Nancy Sun
  • DESIGN OF STABLE AND AGGREGATION FREE ANTIBODY FC MOLECULES THROUGH CH3 DOMAIN INTERFACE ENGINEERING
    Publication number: 20120116057
    Abstract: The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
    Type: Application
    Filed: June 29, 2010
    Publication date: May 10, 2012
    Applicant: AMGEN INC.
    Inventors: Gunasekaran Kannan, Hongxing Zhou
  • METHOD FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS
    Publication number: 20100286374
    Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer. Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.
    Type: Application
    Filed: January 6, 2009
    Publication date: November 11, 2010
    Inventors: Gunasekaran Kannan, Michael Wittekind, Wei Yan, Martin Pentony