Patents by Inventor Gunda Georg
Gunda Georg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240109872Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.Type: ApplicationFiled: August 11, 2023Publication date: April 4, 2024Applicant: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Narsihmulu Cheryala
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Publication number: 20240067603Abstract: Biguanide compounds of formula where R1 comprises a cubanyl-substituted alkyl and R2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.Type: ApplicationFiled: December 16, 2021Publication date: February 29, 2024Inventors: David A. POTTER, Zhijun GUO, Gunda GEORG, Kwon Ho HONG, Jianxun LEI, Elizabeth AMBROSE, Kris WHITE
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Publication number: 20240002339Abstract: The invention provides a compound of Formula (I): or a salt thereof, wherein R1-R3, R5-R11, Z, X, and L have any of the values described in the specification, as well as compositions comprising a compound of Formula (I). The compounds are useful as cyclin-dependent kinase 2 (CDK2) inhibitors.Type: ApplicationFiled: June 29, 2023Publication date: January 4, 2024Inventors: Ingrid Gunda Georg, Timothy Ward, Erik Faber, Jon E. Hawkinson, Nan Wang, Ernst Schonbrunn
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Patent number: 11780828Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.Type: GrantFiled: May 3, 2022Date of Patent: October 10, 2023Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Ingrid Gunda Georg, Narsihmulu Cheryala
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Publication number: 20220388993Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.Type: ApplicationFiled: May 3, 2022Publication date: December 8, 2022Applicant: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Narsihmulu Cheryala
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Patent number: 10272055Abstract: Biguanide compounds and salts thereof are disclosed. Also disclosed are pharmaceutical compositions and therapeutic methods for treating certain diseases including cancer such as breast cancer.Type: GrantFiled: March 6, 2015Date of Patent: April 30, 2019Assignees: Regents of the University of Minnesota, The Regents of the University of CaliforniaInventors: David A. Potter, Zhijun Guo, Elizabeth Amin, Gunda Georg, Tom Poulos, Irina Sevrioukova
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Patent number: 10183033Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: GrantFiled: March 21, 2017Date of Patent: January 22, 2019Assignee: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Publication number: 20180036321Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: ApplicationFiled: March 21, 2017Publication date: February 8, 2018Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Patent number: 9623035Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: GrantFiled: August 26, 2015Date of Patent: April 18, 2017Assignee: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Patent number: 9580459Abstract: Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.Type: GrantFiled: April 25, 2014Date of Patent: February 28, 2017Assignee: Metselex, Inc.Inventors: Peter Ian Dosa, Clifford John Steer, Ingrid Gunda Georg
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Publication number: 20160051571Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: ApplicationFiled: August 26, 2015Publication date: February 25, 2016Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Publication number: 20150342909Abstract: Biguanide compounds and salts thereof are disclosed. Also disclosed are pharmaceutical compositions and therapeutic methods for treating certain diseases including cancer such as breast cancer.Type: ApplicationFiled: March 6, 2015Publication date: December 3, 2015Inventors: David A. Potter, Zhijun Guo, Elizabeth Amin, Gunda Georg, Tom Poulos, Irina Sevrioukova
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Patent number: 9150600Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: GrantFiled: July 10, 2013Date of Patent: October 6, 2015Assignee: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Publication number: 20140323748Abstract: Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.Type: ApplicationFiled: April 25, 2014Publication date: October 30, 2014Inventors: Peter Ian Dosa, Clifford John Steer, Ingrid Gunda Georg
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Publication number: 20140107077Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: ApplicationFiled: July 10, 2013Publication date: April 17, 2014Inventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Patent number: 8507552Abstract: The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: GrantFiled: May 7, 2010Date of Patent: August 13, 2013Assignee: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
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Patent number: 8377958Abstract: Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.Type: GrantFiled: July 6, 2010Date of Patent: February 19, 2013Assignee: The University of KansasInventors: Ingrid Gunda Georg, Joseph S. Tash, Ramappa Chakrasali, Sudhakar Rao Jakkaraj, Katherine Roby
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Patent number: 8362031Abstract: Lonidamine derivatives can be useful in methods of treating, inhibiting, and/or preventing polycystic kidney disease (PKD). Accordingly, lonidamine derivatives can be administered in a therapeutically effective amount for inhibiting, and/or preventing polycystic kidney disease (PKD) in the subject. This can include administering a therapeutically effective amount of the lonidamine derivatives for inhibiting CFTR and/or Hsp90 or biological pathway thereof. Also, the method can include administering the lonidamine derivatives in a therapeutically effective amount for inhibiting ErbB2, Src, Raf-1, B-Raf, MEK, Cdk4, NKCC1, or combinations thereof. For example, the therapeutically effective amount of the lonidamine derivatives can be configured so as to provide a concentration in or adjacent to a kidney cell of about 0.25 uM or more or less.Type: GrantFiled: February 27, 2009Date of Patent: January 29, 2013Assignee: University of KansasInventors: Ingrid Gunda Georg, Joseph S. Tash, Ramappa Chakrasali, Sudhakar Rao Jakkaraj, James P. Calvet
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Patent number: 8318787Abstract: A prodrug that has a prodrug moiety that degrades into a compound having the general Formula I with R3 being an alcoholic moiety can be useful in therapies for neurodegenerative diseases as well as cancer. Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen; R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or unsubstituted; and R3 is a prodrug moiety. As examples, the prodrug can have a structure of any of Formulas I-V, which as shown in the specification.Type: GrantFiled: August 10, 2009Date of Patent: November 27, 2012Assignee: University of KansasInventors: Roger A. Rajewski, Mehmet Tanol, Ingrid Gunda Georg, Michelle P. McIntosh
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Publication number: 20120238529Abstract: The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.Type: ApplicationFiled: May 7, 2010Publication date: September 20, 2012Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers