Patents by Inventor Gundu Rao Padakandla

Gundu Rao Padakandla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of bazedoxifene acetate and intermediates thereof
    Patent number: 8889896
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a).
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: November 18, 2014
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • Process for the preparation of sucralose
    Patent number: 8884004
    Abstract: The present invention provides a method for preparing colorless sucralose, wherein 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acetate containing colored impurities formed during chlorination of sucrose-6-acetate is treated with sodium hypochlorite, where sodium hypochlorite acts both as a decolorizing agent and as a reagent for the ester hydrolysis.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: November 11, 2014
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Process for the preparation of enantiomerically pure -leucine
    Patent number: 8835676
    Abstract: Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: September 16, 2014
    Assignee: Divi's Laboratories Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Process for the preparation of (1S, 3S, 5S)-2-[2(S)--amino-2-(3-hydroxy-1-adamantan-1-yl) acetyl]-2-azabicyclo [3.1.0] hexane-3-carbonitrile
    Patent number: 8664443
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: March 4, 2014
    Assignee: Divi's Laboratories Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • PROCESS FOR THE PREPARATION OF (1S, 3S, 5S)-2-[2(S)-2-AMINO-2-(3-HYDROXY-1-ADAMANTAN-1-YL ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE
    Publication number: 20130317235
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-242(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Application
    Filed: September 4, 2012
    Publication date: November 28, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20130289296
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a)
    Type: Application
    Filed: June 3, 2013
    Publication date: October 31, 2013
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • Process for the preparation of bazedoxifene acetate and intermediates thereof
    Patent number: 8569483
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a)
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: October 29, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • Process for the preparation of gabapentin
    Patent number: 8431739
    Abstract: This invention discloses a process for converting gabapentin acid salt to free gabapentin, where the salt is dissolved in an organic solvent in which both gabapentin acid salt and free gabapentin are soluble. The solution is treated with a powdered alkaline base to liberate free gabapentin which will remain in solution. The insoluble alkali salt of the acid is removed by filtration. From the filtrate free gabapentin is obtained either by adding anti-solvent or by extraction with water.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: April 30, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin, Maddipati Prasad
  • PROCESS FOR THE PREPARATION OF SUCRALOSE
    Publication number: 20130060018
    Abstract: The present invention provides a method for preparing colorless sucralose, wherein 4,1?,6?-trichloro-4,1?,6?-trideoxy-galacto sucrose-6- acetate containing colored impurities formed during chlorination of sucrose-6-acetate is treated with sodium hypochlorite, where sodium hypochlorite acts both as a decolorizing agent and as a reagent for the ester hydrolysis.
    Type: Application
    Filed: November 8, 2011
    Publication date: March 7, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Process for isomerisation of lycopene in the presence of thiourea
    Patent number: 8389790
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: March 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali
  • Process for the preparation of (R,S)-nicotine
    Patent number: 8389733
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: March 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the resolution of (R,S)-nicotine
    Patent number: 8378111
    Abstract: (R,S)-Nicotine was resolved through diastereomeric salt formation using dibenzoyl-d-tartaric acid and dibenzoyl-l-tartaric acid to obtain enantiomerically pure (S)-nicotine and (R)-nicotine.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: February 19, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the preparation of (R, S)-nicotine
    Patent number: 8378110
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: February 19, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the preparation of (R,S)-nicotine
    Patent number: 8367837
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: February 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030188
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030187
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20120330008
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a)
    Type: Application
    Filed: September 8, 2011
    Publication date: December 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • PREPARATION OF 2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID
    Publication number: 20120309973
    Abstract: Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 6, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Krishnaji Rao Mutyala
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE
    Publication number: 20120245379
    Abstract: Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.
    Type: Application
    Filed: June 7, 2011
    Publication date: September 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20120209006
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 16, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta