Abstract: There is provided a method and model insects for screening the effects of nanoparticles on brain barrier function and integrity. The method involves exposing the insect brain-barrier to the nanoparticle(s) of interest and exposing the nanoparticle treated insect brain barrier to one or more suitable marker(s) of the function and integrity of the brain barrier.

Abstract: A radar system for a synthetic aperture radar including an arrangement of at least one transmitter, two receivers, two antennas and signal processing means located on a platform. The platform is arranged to move over ground and arranged to transmit a known signal shape and receive signals reflected from the ground. The received signals are used to produce a synthetic aperture radar image of the ground. The synthetic aperture radar image includes a number of resolution cells. The radar system is further arranged to operate in a frequency band with a center frequency and with a wide bandwidth of at least one octave. A first antenna and a second antenna have a length of less than half the wavelength of the center frequency. The radar system is further arranged for: a radar system transfer function to be flat over the frequency band and one-sided beam forming with wideband antenna gain. Also a corresponding method.

Abstract: The present invention relates to a method (400) and a system (100) for guiding a robotic garden tool to a predetermined position. The robotic garden tool includes a control unit (104) and a sensor unit (102) to detect guiding signals. The sensor unit (102) detects a first guiding signal (110) from a first signal source (106) and the robotic garden tool follows the first guiding signal (110) at a variable distance from the first signal source (106) towards the predetermined position. While within a predetermined distance (D) from the predetermined position, the sensor unit (102) detects a second guiding signal (112) from a second signal source (108). Within the predetermined distance (D), the robotic garden tool follows one of the first and the second guiding signals (110 or 112) towards the predetermined position at a pre-configured distance from the corresponding signal source.

Abstract: There is provided an ex-vivo insect screening model to determine blood-brain barrier penetration of different chemical compounds. The method comprises the steps: • Optionally anesthetizing the insect • Fixing the head of the insect • Dissecting out the brain of the insect head thereby removing the brain from its cuticle • Optinally removing the neural lamella of the brain • Treating the brain with a solution of the chemical compound • Washing anf homogenising or ultra sound disintegrating the brain • Determining the concentration of the chemical compound in the homogenised brain material and • Calculating the penetration of the chemical compound through the blood-brain barrier The concentration of the chemical compound is determined by LC/MS and the chemical compound can be a CNS drug.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: The present invention relates to a method (400) and a system (100) for guiding a robotic garden tool to a predetermined position. The robotic garden tool includes a control unit (104) and a sensor unit (102) to detect guiding signals. The sensor unit (102) detects a first guiding signal (110) from a first signal source (106) and the robotic garden tool follows the first guiding signal (110) at a variable distance from the first signal source (106) towards the predetermined position. While within a predetermined distance (D) from the predetermined position, the sensor unit (102) detects a second guiding signal (112) from a second signal source (108). Within the predetermined distance (D), the robotic garden tool follows one of the first and the second guiding signals (110 or 112) towards the predetermined position at a pre-configured distance from the corresponding signal source.

Abstract: There is provided a new methodology for initial assessment of compound PK. The invention is generally particular useful for efficient screening of and assessment of PK profiles of newly synthesized compounds in the early phase of drug discovery.

Abstract: There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and the uptake into the brain is analysed. Thus, in this model it is possible to investigate the potential up-take into the brain of nanoparticles circulating in the blood.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: A radar system for a synthetic aperture radar including an arrangement of at least one transmitter, two receivers, two antennas and signal processing means located on a platform. The platform is arranged to move over ground and arranged to transmit a known signal shape and receive signals reflected from the ground. The received signals are used to produce a synthetic aperture radar image of the ground. The synthetic aperture radar image includes a number of resolution cells. The radar system is further arranged to operate in a frequency band with a center frequency and with a wide bandwidth of at least one octave. A first antenna and a second antenna have a length of less than half the wavelength of the center frequency. The radar system is further arranged for: a radar system transfer function to be flat over the frequency band and one-sided beam forming with wideband antenna gain. Also a corresponding method.

Abstract: There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.

Abstract: A method for determining the relative humidity of an insulating liquid filled electric apparatus including a container containing insulating liquid and gas, a communication unit providing communication between the gas of the container and gas of an external environment, and providing dehydration of gas passing through the communication unit, wherein the method includes: continuously measuring and storing the relative humidity of the gas in the container, calculating an average value of the relative humidity in the gas based on the stored humidity measurements during a certain time period, and determining the relative humidity of the insulating liquid based on the average value of the relative humidity in the gas and a relationship between the relative humidity of the gas and the relative humidity of the insulating liquid at equilibrium.

Abstract: A universal control and diagnostic system for a transformer that may be retrofit with existing control and tap-changer equipment, the system providing for remote monitoring and control of the equipment and for measuring various criteria associated with the tap-changer to substantially minimize damage to the equipment during a maneuver and for substantially avoiding carbonization of a connected contact.

Abstract: A universal control and diagnostic system for a transformer that may be retrofit with existing control and tap-changer equipment, the system providing for remote monitoring and control of the equipment and for measuring various criteria associated with the tap-changer to substantially minimize damage to the equipment during a maneuver and for substantially avoiding carbonization of a connected contact.

Abstract: A method and means for diagnosing transformer tap changers is provided. Pressure is monitored in an insulating liquid of a tap changer for a period of time in which switching of the tap changer is carried through. Switching-related information is extracted from the pressure diagram. Quantities from pressure peaks are related to specific arcings of the switching sequence. Early error detection is achieved, whereby transformed failures may be avoided. Repeated measurements may be followed by trend evaluation. If a trend indicating tap changer problems is detected, an alarm signal is triggered. The transformer may be switched off if the pressure exceeds a predetermined emergency value. Information of the base pressure in the tap changer may be extracted and converting it to level of insulating liquid.

Abstract: A method and apparatus for condition diagnosing of a tap changer immersed in a cooling fluid, controlling and regulating an inductive power device, such as a transformer or reactor. The diagnosing method compares and evaluates expected heat exchanges between the tap changer and ambient air and the inductive power device, an expected amount of heat generated by the tap changer during operation, together with an actual temperature of the fluid. From the actual temperature, expected heat exchanges and expected generated heat, the heat balance in the system may be obtained and is used for disgnosing the operation conditions of the tap changer. The results from the condition diagnosing may be used as indicators that can alarm operators or may be sent as a data signal to remote and/or portable display means, such as a computer.

Abstract: Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.

Abstract: Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.

Abstract: A method and means for diagnosing transformer tap changers is provided. Pressure is monitored in an insulating liquid of a tap changer for a period of time in which switching of the tap changer is carried through. Switching-related information is then extracted from the pressure diagram. The method, preferably used for single-phase tap changers, comprises the step of relating quantities from pressure peaks to specific arcings of the switching sequence. Early error detection is achieved, whereby transformed failures may be avoided. Repeated measurements ae followed by trend evaluation. If a trend indicating tap changer problems is detected, an alarm signal is triggered. The invention may include switching off the transformer if the pressure exceeds a predetermined emergency value as well as extracting information of the base pressure in the tap changer and converting it to level of insulating liquid.