Abstract: The invention relates to a method for preparing primed seed, a method for improving the germination rate of seed, and a use of a gaseous composition. The method for preparing primed seed comprises successively: providing seed that is capable of germinating, exposing said seed to a treatment atmosphere for an exposure time of at least 1 second, wherein the treatment atmosphere has a relative humidity of 50% or more and a temperature of 50-100° C., and wherein the exposure time has a duration of 30 minutes or less, and cooling and optionally drying said seed.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: A charging coupling for connecting a robotic garden tool with a charging device may facilitate the charging of a battery of the robotic garden tool. The charging coupling may include a first charging contact and a second charging contact. The first charging contact may be a charging plate or a charging rod. The second charging contact may be provided with a row of resilient contact bars. The arrangement of the first charging contact and the second charging contact may be configured such that the resilient contact bars are pressed against the charging plate to provide multiple contact points.

Abstract: There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.

Abstract: There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: A method for determining the relative humidity of an insulating liquid filled electric apparatus including a container containing insulating liquid and gas, a communication unit providing communication between the gas of the container and gas of an external environment, and providing dehydration of gas passing through the communication unit, wherein the method includes: continuously measuring and storing the relative humidity of the gas in the container, calculating an average value of the relative humidity in the gas based on the stored humidity measurements during a certain time period, and determining the relative humidity of the insulating liquid based on the average value of the relative humidity in the gas and a relationship between the relative humidity of the gas and the relative humidity of the insulating liquid at equilibrium.

Abstract: There is provided a method and model insects for screening the effects of nanoparticles on brain barrier function and integrity. The method involves exposing the insect brain-barrier to the nanoparticle(s) of interest and exposing the nanoparticle treated insect brain barrier to one or more suitable marker(s) of the function and integrity of the brain barrier.

Abstract: A radar system for a synthetic aperture radar including an arrangement of at least one transmitter, two receivers, two antennas and signal processing means located on a platform. The platform is arranged to move over ground and arranged to transmit a known signal shape and receive signals reflected from the ground. The received signals are used to produce a synthetic aperture radar image of the ground. The synthetic aperture radar image includes a number of resolution cells. The radar system is further arranged to operate in a frequency band with a center frequency and with a wide bandwidth of at least one octave. A first antenna and a second antenna have a length of less than half the wavelength of the center frequency. The radar system is further arranged for: a radar system transfer function to be flat over the frequency band and one-sided beam forming with wideband antenna gain. Also a corresponding method.

Abstract: The present invention relates to a method (400) and a system (100) for guiding a robotic garden tool to a predetermined position. The robotic garden tool includes a control unit (104) and a sensor unit (102) to detect guiding signals. The sensor unit (102) detects a first guiding signal (110) from a first signal source (106) and the robotic garden tool follows the first guiding signal (110) at a variable distance from the first signal source (106) towards the predetermined position. While within a predetermined distance (D) from the predetermined position, the sensor unit (102) detects a second guiding signal (112) from a second signal source (108). Within the predetermined distance (D), the robotic garden tool follows one of the first and the second guiding signals (110 or 112) towards the predetermined position at a pre-configured distance from the corresponding signal source.

Abstract: There is provided an ex-vivo insect screening model to determine blood-brain barrier penetration of different chemical compounds. The method comprises the steps: • Optionally anesthetizing the insect • Fixing the head of the insect • Dissecting out the brain of the insect head thereby removing the brain from its cuticle • Optinally removing the neural lamella of the brain • Treating the brain with a solution of the chemical compound • Washing anf homogenising or ultra sound disintegrating the brain • Determining the concentration of the chemical compound in the homogenised brain material and • Calculating the penetration of the chemical compound through the blood-brain barrier The concentration of the chemical compound is determined by LC/MS and the chemical compound can be a CNS drug.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: The present invention relates to a method (400) and a system (100) for guiding a robotic garden tool to a predetermined position. The robotic garden tool includes a control unit (104) and a sensor unit (102) to detect guiding signals. The sensor unit (102) detects a first guiding signal (110) from a first signal source (106) and the robotic garden tool follows the first guiding signal (110) at a variable distance from the first signal source (106) towards the predetermined position. While within a predetermined distance (D) from the predetermined position, the sensor unit (102) detects a second guiding signal (112) from a second signal source (108). Within the predetermined distance (D), the robotic garden tool follows one of the first and the second guiding signals (110 or 112) towards the predetermined position at a pre-configured distance from the corresponding signal source.

Abstract: There is provided a new methodology for initial assessment of compound PK. The invention is generally particular useful for efficient screening of and assessment of PK profiles of newly synthesized compounds in the early phase of drug discovery.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and the uptake into the brain is analysed. Thus, in this model it is possible to investigate the potential up-take into the brain of nanoparticles circulating in the blood.

Abstract: A radar system for a synthetic aperture radar including an arrangement of at least one transmitter, two receivers, two antennas and signal processing means located on a platform. The platform is arranged to move over ground and arranged to transmit a known signal shape and receive signals reflected from the ground. The received signals are used to produce a synthetic aperture radar image of the ground. The synthetic aperture radar image includes a number of resolution cells. The radar system is further arranged to operate in a frequency band with a center frequency and with a wide bandwidth of at least one octave. A first antenna and a second antenna have a length of less than half the wavelength of the center frequency. The radar system is further arranged for: a radar system transfer function to be flat over the frequency band and one-sided beam forming with wideband antenna gain. Also a corresponding method.

Abstract: There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.

Abstract: A method for determining the relative humidity of an insulating liquid filled electric apparatus including a container containing insulating liquid and gas, a communication unit providing communication between the gas of the container and gas of an external environment, and providing dehydration of gas passing through the communication unit, wherein the method includes: continuously measuring and storing the relative humidity of the gas in the container, calculating an average value of the relative humidity in the gas based on the stored humidity measurements during a certain time period, and determining the relative humidity of the insulating liquid based on the average value of the relative humidity in the gas and a relationship between the relative humidity of the gas and the relative humidity of the insulating liquid at equilibrium.