Abstract: The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceutically acceptable inorganic or organic cation, or CORA wherein RA is alkyl and aryl; R42 and R43 are hydrogen, C1-C4-alkyl, cyclopropyl, cyclopentyl or cyclohexyl; or R42 is benzyl or phenethyl, optionally mono- or disubstituted by methyl, iso-propyl methoxy, fluoro, chloro, bromo, dimethylamino, trifluoromethyl or nitro and R43 is hydrogen; or R42 and R43 form a 5- or 6-membered ring; or R42 is CORB wherein RB is alkyl or aryl, —CH2N(CH3)2 or —CH2CH2COOH or CORB is a 2-acyloxymethylbenzoyl group wherein RC is methyl, ethyl, phenyl or benzyl; R42 is COORD wherein RD is C1-C4-alkyl, phenyl or benzyl; or R42 is —CH2OCO-tert.

Abstract: A method for stimulation of transcription factor AP (activator protein)-1 by administering a compound of the formula (I) 1

Abstract: The invention is directed to a vibrating tamper having a single control lever. The single control lever (4) can be set by an operator to any three releasably fixed positions with a snap-action detent device holding the control lever in the position selected by the operator. In the first position, the engine ignition is short-circuited, a fuel valve is closed, a fuel tank venting valve is closed and the throttle is fully closed. In the second position, the engine ignition circuit is enabled, the fuel tank venting valve is open, the fuel valve is open and the throttle control is in a starting/idling position. In the third position, the engine ignition circuit is enabled, the fuel tank venting valve is open, the fuel valve is open and the throttle control is in full-throttle position.

Abstract: A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.

Abstract: The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCH.sub.x F.sub.y, whereinx=0-2, y=1-3 with the proviso that x+y=3, R" is hydrogen, fluoro or chloro; with the proviso that R" is fluoro or chloro only when R' is fluoro or chloro; R.sub.4 is hydrogen or pharmaceutically acceptable inorganic or organic cations;R.sub.5 is ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCH.sub.x F.sub.y, or OCH.sub.2 CH.sub.x F.sub.y wherein x=0-2, y=1-3 with the proviso that x+y=3;R.sub.6 is hydrogen; or R.sub.5 and R.sub.6 taken together are methylenedioxy; and any tautomer thereof.The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier.

Abstract: The invention is related to compounds of general formula (I) ##STR1## wherein R is Me, Et, n-Pr, iso-Pr, n-Bu, iso-Bu, sec.-Bu or allyl; R' is hydrogen, Me, MeO, fluoro, chloro, brorno, CF.sub.3, or OCH.sub.x F.sub.y ; R" is hydrogen or fluoro, with the proviso that R" is fluoro when R' is fluoro; and further when R' and R" are both hydrogen, R is not Me; R.sub.4 is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R.sub.5 is selected from MeS, EtS, n-PrS, iso-PrS, MeSO, EtSO, MeSO.sub.2 and EtSO.sub.2 ; wherein x=0-2, y=1-3 with the proviso that x+y=3; and Me is methyl, Et is ethyl, Pr is propsy and Bu is butyl; and any tautomer, optical isomer and racemate thereof. The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier.

Abstract: A rock drill for percussive drilling includes a shank, a collar connected to a front end of the shank, and a rod portion which at one end connects to the collar while the other end carries a rock cutting means. A central flush channel extends from the front free end of the shank in a direction towards the front end. The central flush channel has a substantially constant diameter (d) along essentially its entire length; a ratio of the diameter (d) to a smallest outer cross sectional width (D) of the rod portion being in the range of 0.35 to 0.43.

Abstract: The invention relates to compounds of general formula (I) ##STR1## wherein R is selected from ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R.sub.4 is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R.sub.5 is selected from methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, CF.sub.3, and OCH.sub.x F.sub.y ; wherein x=0-2, y=1-3 with the proviso that x+y=3; R.sub.6 is hydrogen; or R.sub.5 and R.sub.6 taken together are methylenedioxy; and any tautomer hereof. The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods of treating mammals suffering from diseases resulting from autoimmunity and pathological inflammation by administering a compound having the formula (I) to said mammal.

Abstract: Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC), including methods of lysing malignant cells expressing MHC Class II antigens using SDCC, by the administration of staphylococcal enterotoxin to a living body.

Abstract: A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.

Abstract: A percussion drill bit for drilling bores, comprises a drill body having a plurality of gauge row inserts embedded in a front end of the drill body. Each gauge row insert comprises a cemented carbide body having a mounting portion embedded in the drill body, and a front end protruding from the drill body. A polycrystalline diamond layer is provided on the front end of the carbide body. The diamond layer has a rear edge disposed in the vicinity of a maximum diameter of the insert. That rear edge is spaced from the wall of the bore during drilling by tilting the gauge row insert at an acute angle of 41.degree. to 51.degree. relative to the rotational axis of the drill bit. The front end of the carbide body is defined by a radius whose origin lies on a center axis of the insert. That origin is disposed axially rearwardly of a plane containing the rear edge of the diamond layer. The length of that radius is 50% to 52% of a diameter of the mounting portion of the insert.

Abstract: A down-the-hole rock drill includes a top sub, a driver sub having a bore therein, and a piston case extending between and detachably connected to the top sub and the driver sub. A piston is located within the piston case, and a drill device is detachably connected to the driver sub. The drill device includes a shank and a head. The drill device also has a central passageway for a flushing medium. A tube is secured in the central passageway at a free end of the shank. The tube extends beyond the free end of the shank, and the piston has a central piston passageway that receives the tube. The piston is slidably movable relative to the tube. A first portion of the shank located closest to the head has a cross section, normal to a longitudinal center axis of the shank, in the shape of a multi-lobed figure that is continuously non-concave, and the bore of the driver sub is of a matching cross-sectional shape.

Abstract: The present invention related to a drill bit (10) for rock drilling, preferably a down-the-hole drill bit, said drill bit (10) including a head (11) and a shaft (12), said head (11) defining a cutting face (14) that carries a number of hard material button inserts (15) having end portions extending outwardly of said cutting face (14), means (16,17) for transporting flushing medium from the free end (13) of the shaft (12) to the cutting face (14) of the head (11), said means for transporting flushing medium including a central passage (16) extending from the free end (13) of the shaft (12) and terminating in the head (11) short of the cutting face (14) and at least one branch passage (17) emanating from the central passage (16) and emerging in the cutting facc (14).In the field of down-the-hole drill bits big volumes of flushing medium, normally compressed air, are used since the flushing medium is also activating the down-the-hole hammer.

Abstract: A down-the-hole drill tool comprises a one-piece shaft and pilot bit. The shaft is adapted for connection to a down-the-hole hammer. A reamer and a guide body are detachably mounted to the one-piece shaft/pilot bit. The guide body has a downwardly facing shoulder for pushing a casing tube downwardly along with the tool.

Abstract: A tool for cutting solid material includes a tool body having a recess, and a cutting insert received in the recess. The cutting insert has spacing buttons which engage a surface of the recess to create a space for accommodating a brazing material which secures the insert to the tool body. The surface of the recess includes an annular retaining groove which receives the buttons in order to prevent tilting of the insert prior to brazing.

Abstract: The present invention relates to a tool for cutting solid material, the tool including a tool body having a supporting surface, and a cutting insert having a generally conical tip portion and a shoulder portion that is intended to rest against a supporting surface, the cutting insert being secured to the tool body, e.g., by brazing. The invention also relates to the cutting insert per se. The cutting insert has a concave portion between its tip and bottom which concave portion extends circumferentially around the cutting insert. In addition, a special type of cemented carbide is used for the cutting insert.

Abstract: Drive system for a variable reluctance motor having a pulsated drive. The motor has a stator provided with one or more windings for one or more phases, and a rotor which, upon rotation, co-acts with the magnetic circuit in each stator phase and produces in the magnetic circuit for each stator winding a permeance which changes with changes in the rotor angle. A sensing and control circuit (1-10) senses the inductance in the phase winding (L1, L2, L3) in each phase, at least during a part of a rotor revolution. Upon the indication of a pre-determined inductance L.sub.k, the circuit permits the rotational position of the rotor at which the determined inductance L.sub.k was indicated to constitute a starting point for determining a rotational position .theta..sub.OFF) for changing the energized state of the phase winding.

Abstract: A tool is mounted in a holder, the holder including a fluid passage for discharging drilling fluid toward a cutting zone. Fluid flow is regulated by a valve in the holder. The valve includes a housing and a valve element movable in the housing. The valve element opens the valve in response to rearward displacement of the tool relative to the holder. The housing of the valve is also rearwardly displaceable relative to the holder whenever rearward forces transmitted from the tool are excessive, thereby avoiding the occurrence of damage to the valve. The valve housing is yiealdably biased forwardly by fluid pressure in the conduit.

Abstract: A tool for breaking, cutting, and working solid materials includes a rearwardly extending shaft adapted to be inserted into the bore of a holder. The shaft includes an annular groove located adjacent a rearmost end thereof. A cylindrical clip is mounted on the shaft for retaining the tool within the holder. The clip includes a longitudinal slot extending longitudinally completely therethrough. A rear free end of the clip is inwardly bent into the groove of the shaft to oppose longitudinal forward movement of the shaft relative to the clip.

Abstract: Energizing system for a reluctance motor having at least two phases. A sensing and control circuit (1-5) which is constructed to indicate the inductance, or a clearly related magnitude, in the winding in the phase which is next to be energized or activated. The circuit is also constructed to detect the current in the winding in the energized phase and to correct the indicated value of the inductance, or related magnitude, with an operating parameter which has a dependency on the current value in the winding of the energized phase, and to compare this corrected value with a reference value and to utilize the rotational position of the motor rotor, when the corrected value coincides with the reference value, as a starting point for determining a rotational position for changing the energizing state of the phase winding.