Abstract: The invention relates to a hard tissue biopsy sampling device, e.g. for bone in humans or animals, comprising a tube shaped casing or sleeve with a distal end provided with a cutting edge and a proximal end. The invention further comprises a needle insertable in the sleeve, the needle extending out of the distal end of the sleeve, and having a tip allowing penetration in the hard tissue. The sleeve exhibits in the vicinity of its distal end a portion having reduced outer diameter. The distal end has a section with reducing diameter, such that the inner diameter of the interior of the device is continuously reduced over at least the major part of the section. In side projection, the cutting edge forms an angle in relation to a perpendicular plane through the cross-section of the device, the angle preferably being 17.degree.-23.degree..