Abstract: The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an adrenal disease or disorder.

Abstract: The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an adrenal disease or disorder.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for manufacturing anatase TiO2 nanoparticles comprises mixing (210) of Ti-containing alkoxide precursors with a solvent into a precursor solution, hydrolyzing (212) the precursor solution to yield a mixture of a fine titanium containing precipitate and the solvent and hydrothermally treating (214) the precipitate at an elevated temperature in a basic medium. The basic medium is provided after the hydrolysis. The basic medium comprises basic amines. A highly active photocatalytic material is thus presented, comprising anatase TiO2 nanoparticles, which have a mean diameter of less than 100 nm and have at least one of a {111}, a {112}, and a {100} crystal face. The material can be tuned for selective carboxylate-surface coordination.

Abstract: A novel solution route has been developed that after heat-treatment to 500-600° C. under inert atmosphere, yields highly porous composites of nano-sized metal (Ni) particle inclusions in ceramics (Al2O3). Metal loadings could be made from <1% to >95% Ni. The metal inclusion sizes in the Ni—Al2O3 system with the 10 atom % Ni sample were 4-7 nm, while for the 75 atom % Ni sample they were 5-8 nm. It was shown that the 10 atom % Ni sample could be used as a catalyst for the conversion of CO2 and CH4 in the temperature range 550-700° C., while higher temperatures led to growth of the Ni particles and carbon poisoning over time. The solution routes could also be deposited as thin dense films containing <10 nm Ni particles. Such films with high Ni-particle loadings deposited on aluminium substrates have shown very good solar heat absorber proficiency and provide good substrates for carbon tube growth.

Abstract: A novel solution route has been developed that after heat-treatment to 500-600° C. under inert atmosphere, yields highly porous composites of nano-sized metal (Ni) particle inclusions in ceramics (Al2O3). Metal loadings could be made from <1% to >95% Ni. The metal inclusion sizes in the Ni—Al2O3 system with the 10 atom % Ni sample were 4-7 nm, while for the 75 atom % Ni sample they were 5-8 nm. It was shown that the 10 atom % Ni sample could be used as a catalyst for the conversion of CO2 and CH4 in the temperature range 550-700° C., while higher temperatures led to growth of the Ni particles and carbon poisoning over time. The solution routes could also be deposited as thin dense films containing <10 nm Ni particles. Such films with high Ni-particle loadings deposited on aluminium substrates have shown very good solar heat absorber proficiency and provide good substrates for carbon tube growth.

Abstract: A novel solution route has been developed that after heat-treatment to 500-600° C. under inert atmosphere, yields highly porous composites of nano-sized metal (Ni) particle inclusions in ceramics (Al2O3). Metal loadings could be made from <1% to >95% Ni. The metal inclusion sizes in the Ni—Al2O3 system with the 10 atom % Ni sample were 4-7 nm, while for the 75 atom % Ni sample they were 5-8 nm. It was shown that the 10 atom % Ni sample could be used as a catalyst for the conversion of CO2 and CH4 in the temperature range 550-700° C., while higher temperatures led to growth of the Ni particles and carbon poisoning over time. The solution routes could also be deposited as thin dense films containing <10 nm Ni particles. Such films with high Ni-particle loadings deposited on aluminium substrates have shown very good solar heat absorber proficiency and provide good substrates for carbon tube growth.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of diagnosing, prognosing and treating LRP5 related diseases, specifically hyperthyroidism and parathyroid tumors, and kits suitable for rapid on-site testing. Finally, methods of screening for agents capable of modulating the mutant LRP5 or LRP6 receptor proteins and pharmaceutical compositions comprising the selected agents.

Abstract: A novel solution route has been developed that after heat-treatment to 500-600° C. under inert atmosphere, yields highly porous composites of nano-sized metal (Ni) particle inclusions in ceramics (Al2O3). Metal loadings could be made from <1% to >95% Ni. The metal inclusion sizes in the Ni-Al2O3 system with the 10 atom % Ni sample were 4-7 nm, while for the 75 atom % Ni sample they were 5-8 nm. It was shown that the 10 atom % Ni sample could be used as a catalyst for the conversion of CO2 and CH4 in the temperature range 550-700° C., while higher temperatures led to growth of the Ni particles and carbon poisoning over time. The solution routes could also be deposited as thin dense films containing <10 nm Ni particles. Such films with high Ni-particle loadings deposited on aluminium substrates have shown very good solar heat absorber proficiency and provide good substrates for carbon tube growth.

Abstract: There is disclosed a method of coating cemented carbide inserts at least partly with a layer of at least one iron group metal. When inserts coated with such a layer are brazed to a tool holder, a joint with improved strength is obtained. According to the present method, one or more metal salts of at least one iron group metal containing organic groups are dissolved and complex bound in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3 (R.dbd.H or alkyl). A soluble carbon source is added to the solution which is subsequently at least partly applied to the cemented carbide inserts by dipping, spraying or painting. The inserts are dried and heat treated in an inert and/or reducing atmosphere. As a result, cemented carbide inserts are obtained at least partly coated with a layer of an iron group metal.

Abstract: A method of making a hard constituent powder coated with at least one iron group metal, Me, by dissolving and complex binding at least one of Me.sub.n (NO.sub.3).sub.m and Me.sub.n (SO.sub.4).sub.m and other similar Me.sub.n --X.sub.m compounds containing X-groups with low or no carbon content, preferably Me-nitrates, solely or together with one or more metal salts of at least one iron group metal containing organic groups in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3, (R=H or alkyl). Hard constituent powder is added to the solution. The solvent is evaporated and remaining powder is heat treated in an inert and/or reducing atmosphere. As a result, coated hard constituent powder is obtained which after addition of a pressing agent can be compacted and sintered according to standard practice.

Abstract: A method wherein one or more metal salts of at least one iron group metal containing organic groups are dissolved and complex bound in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3, (RH.dbd.H or alkyl). Hard constituent powder and, optionally, a soluble carbon source are added to the solution. The solvent is evaporated and the remaining powder is heat treated in an inert and/or reducing atmosphere. As a result, coated hard constituent powder is obtained which after addition of a pressing agent can be compacted and sintered according to standard practice to a body containing hard constituents in a binder phase.