Patents by Inventor Gunter M. Fless

Gunter M. Fless has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression and purification of kringle domains of human apolipoprotein (a) in E. coli
    Patent number: 6372886
    Abstract: Methods for the expression of kringle domains of apoliprotein(a) are described. The domains, including kringle 4 domains and the unique kringle 5 domain, are efficiently expressed as fusion proteins from transformed Escherichia coli host cells. The fusion polypeptides may be employed directly to generate antibodies to human lipoprotein (a) or cleaved to provide the pure kringle polypeptide. Monoclonal antibodies to the kringle 4 domains and to kringle 5 domain may be employed to assay levels of human apolipoprotein (a) in blood as a measure of risk of coronary heart disease.
    Type: Grant
    Filed: May 11, 1994
    Date of Patent: April 16, 2002
    Assignee: Arch Development Corp.
    Inventors: Gunter M. Fless, Angelo M. Scanu