Abstract: Polymeric composition, material produced thereof and their applications The invention relates to a novel polymer composition comprising at least one copolymer constituted of acrylic (AC) monomer units and of at least one water-soluble comonomer unit, which is preferably 2-acrylamido-2-methyl-propane sulfonic acid (AMPS). The composition is used to produce materials, such as membranes, film or suface coatings, that are suitable as highly tissue compatible supports for epithelial cells, such as hepatocytes. The materials are suitable to be used in a bioartificial liver, where they work as separating membrane and carrier for adhesion-dependent tissue cells. As an example it is described how selectively permeable membranes are formed by a phase inversion process from these acrylic copolymers with varying content of 2-acrylamido-2-methyl-propane sulfonic acid (AMPS) and how they interact with liver cells to construct a biohybrid organ for liver replacement.

Abstract: In a method of making solvent and acid resistant membrane on the basis of polyacrylnitrile (PAN) and a comonomer copolymerized therewith wherein the membrane is formed from a solution by phase inversion, glycidylmethacrylate is used as the comonomer and the membrane formed thereby is then subjected to ammonia.