Patents by Inventor Gunter Maubach

Gunter Maubach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION
    Publication number: 20140024038
    Abstract: The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.
    Type: Application
    Filed: July 23, 2013
    Publication date: January 23, 2014
    Inventors: Gunter Maubach, Lang Zhuo, Michelle Chin Chia Lim
  • METHOD FOR DIFFERENTIATING EMBRYONIC STEM CELLS INTO CELLS EXPRESSING AQP-1
    Publication number: 20130268060
    Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
    Type: Application
    Filed: June 13, 2013
    Publication date: October 10, 2013
    Inventors: Karl M. Schumacher, Jackie Y. Ying, Annegret Schumacher, Karthikeyan Narayanan, Gunter Maubach
  • Method for differentiating embryonic stem cells into cells expressing AQP-1
    Patent number: 8481316
    Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: July 9, 2013
    Assignee: Agency for Science, Technology and Research
    Inventors: Karl M. Schumacher, Jackie Y. Ying, Annegret Schumacher, Karthikeyan Narayanan, Gunter Maubach
  • METHOD OF INHIBITING PROLIFERATION OF HEPATIC STELLATE CELLS
    Publication number: 20110275574
    Abstract: There is presently provided a method of inhibiting proliferation of a hepatic stellate cell comprising directly down-regulating the hepatic stellate cell proliferation activity of connexin-43 in the hepatic stellate cell for the treatment of hepatic fibrosis or related disorder. This method primarily involves down regulating connexin-43 with agents such as Snai1, siRNAs, antisense RNA and DNA enzymes directed against the connexin-43 transcript. As a result the proliferation of activated hepatic stellate cells is down regulated.
    Type: Application
    Filed: January 15, 2010
    Publication date: November 10, 2011
    Applicant: Agency for Science, Technology and Research
    Inventors: Lang Zhuo, Michelle Chin Chia Lim, Gunter Maubach
  • METHOD FOR DIFFERENTIATING EMBRYONIC STEM CELLS INTO CELLS EXPRESSING AQP-1
    Publication number: 20110070280
    Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
    Type: Application
    Filed: July 21, 2008
    Publication date: March 24, 2011
    Inventors: Karl M. Schumacher, Jackie Y. Ying, Annegret Schumacher, Karthikeyan Narayanan, Gunter Maubach
  • Hepatic stellate cell specific promoter and uses thereof
    Patent number: 7863251
    Abstract: Methods and reagents for effecting transgene expression in Hepatic Stellate Cells (HSC) comprising a 2.2 kb fragment of the promoter region of the Glial Fibrillary Acidic Protein (GFAP) gene, said construct being up-regulated by pro-fÊbronetic cytokines such as TGF-beta 1 in a dose and time dependent manner, and uses thereof.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: January 4, 2011
    Assignee: Agency for Science, Technology and Research
    Inventors: Lang Zhuo, Gunter Maubach
  • METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION
    Publication number: 20100292298
    Abstract: The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.
    Type: Application
    Filed: April 23, 2007
    Publication date: November 18, 2010
    Applicant: Agency for Science, Technology and Research
    Inventors: Gunter Maubach, Lang Zhuo, Michelle Chin Chia Lim
  • HEPATIC STELLATE CELL SPECIFIC PROMOTER AND USES THEREOF
    Publication number: 20090202502
    Abstract: Methods and reagents for effecting transgene expression in Hepatic Stellate Cells (HSC) comprising a 2.2 kb fragment of the promoter region of the Glial Fibrillary Acidic Protein (GFAP) gene, said construct being up-regulated by pro-fÊbronetic cytokines such as TGF-beta 1 in a dose and time dependent manner, and uses thereof.
    Type: Application
    Filed: June 9, 2006
    Publication date: August 13, 2009
    Applicant: AGENCY FOR SCIENCE TECHNOLOGY & RESEARCH
    Inventors: Lang Zhuo, Gunter Maubach
  • Hepatic stellate cell specific promoter and uses thereof
    Publication number: 20070299029
    Abstract: Methods and reagents for effecting transgene expression in a hepatic stellate cell, isolated transgenic hepatic stellate cells, methods and reagents for identifying compounds with fibrogenesis modulating properties and uses thereof.
    Type: Application
    Filed: February 2, 2007
    Publication date: December 27, 2007
    Inventors: Lang Zhuo, Gunter Maubach, Chun-Yan Zhang
  • Nucleic acids encoding chimeric proteins comprising BMP-2 and a proteinase inhibitor
    Patent number: 7179795
    Abstract: This invention relates to an agent for producing a pharmaceutical drug for postoperative use after removal of bone tumors produced from a nucleic acid by linking a known sequence for promoting bone growth and a known proteinase inhibitor by a variable spacer molecule. This linkage results in a novel bifunctional active ingredient combining both properties in a biological molecule. This invention is used in the medical field, in particular in the specialty field of orthopedics.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: February 20, 2007
    Assignee: Depuy Biotech Jena GmbH
    Inventors: Bernd Wiederanders, Gunter Maubach
  • Agent for postoperative use after removal of bone tumours
    Publication number: 20040087524
    Abstract: This invention relates to an agent for producing a pharmaceutical drug for postoperative use after removal of bone tumors produced from a nucleic acid by linking a known sequence for promoting bone growth and a known proteinase inhibitor by a variable spacer molecule. This linkage results in a novel bifunctional active ingredient combining both properties in a biological molecule. This invention is used in the medical field, in particular in the specialty field of orthopedics.
    Type: Application
    Filed: February 3, 2003
    Publication date: May 6, 2004
    Inventors: Bernd Wiederanders, Gunter Maubach