Patents by Inventor Gunter Metz

Gunter Metz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030077206
    Abstract: A reactor and a process for carrying out parallel reactions on solids is described. The reactor comprises at least a sample holder block (1) with a multiplicity of reaction vessels (2a-2k), a heated support structure (3) and a cover (8, 9, 10) sealing all the reaction vessels (2a-2k). The cover (8, 9, 10) contains feed lines (4a-4k) and discharge lines (5a-5k) to each sample vessel (2a-2k). The feed lines (4a-4k) and/or the discharge lines (5a-5k) are joined together by means of feed and discharge channels (7, 8) running crosswise to said lines. The feed and discharge channels (7, 8) end in main fluid feed lines (11) and discharge lines (12).
    Type: Application
    Filed: April 24, 2002
    Publication date: April 24, 2003
    Inventors: Gunter Metz, Olaf Gluck, Holger Orzesek, Michael Venz, Gerhard Wegener, Markus Dugal
  • Patent number: 4980498
    Abstract: By using a new method 2-(2-hydroxyethoxy)-ethanol ester is produced from flufenamic acid as a result of direct esterification with diol with an excess of 8-15 mol diol per mol flufenamic acid without concurrent removal of water.
    Type: Grant
    Filed: March 31, 1989
    Date of Patent: December 25, 1990
    Assignee: Merckle GmbH
    Inventor: Gunter Metz
  • Patent number: 4960793
    Abstract: Novel diethylene glycol monoester of antirheumatically effective acids, e.g., lonazolac and diclofenac and others are disclosed which have inflammation inhibitory properties superior to the corresponding acid base forms. They may be produced through direct esterification without elimination of water and are suitable in the fight against diseases of the rheumatic complex.
    Type: Grant
    Filed: March 31, 1989
    Date of Patent: October 2, 1990
    Assignee: Merckle GmbH
    Inventors: Gunter Metz, Kurt Rauchle, Manfred Erdmann
  • Patent number: 4593044
    Abstract: The invention relates to the use of naproxen lysinate, ketoprofen lysinate and/or diclofenac lysinate in the form of an injectable solution in the treatment of inflammations and rheumatic disorders, and to injectable solutions containing the anti-inflammatory active compound naproxen, ketoprofen or diclofenac in the form of its lysinate.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: June 3, 1986
    Assignee: Merckle GmbH
    Inventor: Gunter Metz
  • Patent number: 4505914
    Abstract: At least one barbiturate or one of its pharmaceutically acceptable salts is combined with cinnarizine or flunarizine or one of their pharmaceutically acceptable salts to provide a hypnotic requiring lower dosages of barbiturates to produce the same effect as the barbiturate alone.
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: March 19, 1985
    Assignee: Merckle GmbH
    Inventors: Gunter Metz, Kurt Rauchle
  • Patent number: 4361032
    Abstract: An apparatus for automatically determining the surface tension by the stalagmometer principle using a pipette containing a test volume, having a drop face at its lower end and is provided with three light barriers. The three light barriers are connected to an evaluation circuit which counts the number of whole drops and also determines the fractions of whole drops pertaining to the test volume.
    Type: Grant
    Filed: September 12, 1980
    Date of Patent: November 30, 1982
    Assignee: Agfa-Gevaert Aktiengesellschaft
    Inventors: Werner Lessnig, Gunter Metz, Willi Spiegel, Manfred Faust, Gunter Junkers
  • Patent number: 4294851
    Abstract: The object of the present invention are novel aminobenzoic acid derivatives having the general formula: ##STR1## wherein R.sub.1 is hydrogen, chlorine, hydroxy, acetoxy or C.sub.1 -C.sub.3 -alkoxy;R.sub.2 is hydrogen, chlorine or sulfamoyl;R.sub.5 is hydrogen or combined with R.sub.6 a C.sub.2 -C.sub.3 -alkylene;Y is the group ##STR2## or in ortho-position together with the hydrogen atom on the nitrogen and with R.sub.5 the group ##STR3## wherein R.sub.3 is hydrogen or methyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.3 -alkyl, or with Z substituted phenoxy; andZ is hydrogen, halogen or trifluoromethyl;X is C.sub.1 -C.sub.3 -alkylene forming, if necessary, under substitution with R.sub.6 a 5- or 6-link aliphatic or aromatic ring system;R.sub.6 is C.sub.1 -C.sub.4 -alkyl or in combination with X a C.sub.3 -C.sub.4 -cycloalkylene or cycloarylene;R.sub.7 is hydrogen, C.sub.1 -C.sub.3 -alkyl, formyl, the group Y, or together with R.sub.6 a C.sub.4 -C.sub.5 -cycloalkylene, or together with X and R.sub.6 pyridylmethyl;R.
    Type: Grant
    Filed: June 27, 1978
    Date of Patent: October 13, 1981
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 4246264
    Abstract: The use of etofylline clofibrate for the treatment of elevated serum levels of uric acid in humans is disclosed.
    Type: Grant
    Filed: January 17, 1980
    Date of Patent: January 20, 1981
    Assignee: Ludwig Merckle, K.G., Chem. Pharm. Fabrik
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 4156003
    Abstract: The use of the combination of clofibrinic acid or clofibrate with cinnarizine for the treatment of hypertension in humans is disclosed.
    Type: Grant
    Filed: August 24, 1978
    Date of Patent: May 22, 1979
    Assignee: Ludwig Merckle K.G., Chem. Pharm. Fabrik
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 4146637
    Abstract: There are disclosed N-acyl substituted benzamides of the general formula: ##STR1## wherein: X is carbon or nitrogen;R.sub.1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy;Y is the radical --O--, --NH-- or --S--;Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group;R.sub.2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; andThe value of n, m, and p may each be 0 or 1, and in the case of p=1, pharmaceutically acceptable salts thereof.Also disclosed is a method for making such compounds and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: March 27, 1979
    Assignee: Ludwig Merckle K.G., Chem. Pharm. Fabrik
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 4096965
    Abstract: A device for the storage of sample containers comprises a holder for receiving the sample containers and a covering, whereby a common covering is provided for all the sample containers which seals them individually and simultaneously.
    Type: Grant
    Filed: September 17, 1976
    Date of Patent: June 27, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Lessnig, Gunter Metz, Willi Spiegel, Jurgen Fleischer
  • Patent number: 4073918
    Abstract: Phenoxyalkylcarboxylic acid amides and their preparation is described. These compounds are useful as antihypercholesteremic agents.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: February 14, 1978
    Assignee: Ludwig Merckle KG
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 4008324
    Abstract: Salts of 1-cinnamyl-4-diphenylmethyl piperazine and their method of preparation of compositions thereof is described. These compounds have antihypercholesteremic activity.
    Type: Grant
    Filed: January 20, 1976
    Date of Patent: February 15, 1977
    Assignee: Ludwig Merckle KG
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 3985790
    Abstract: A novel pharmaceutically useful compound, the p-chlorophenoxyisobutyrate salt of 4-(p-chlorophenoxyacetyl-amino)-benzene carboxylic acid diethylaminoethyl ester, is disclosed, which has superior antilipemic and anticholesteremic properties.
    Type: Grant
    Filed: July 23, 1974
    Date of Patent: October 12, 1976
    Assignee: Ludwig Merckle KG
    Inventors: Gunter Metz, Manfred Specker
  • Patent number: 3984413
    Abstract: Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic properties as well as pronounced peripheral and vasodilative effect.
    Type: Grant
    Filed: February 21, 1974
    Date of Patent: October 5, 1976
    Assignee: L. Merckle KG
    Inventors: Gunter Metz, Manfred Specker