Patents by Inventor Gunter Schabert
Gunter Schabert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240059727Abstract: The present invention relates to methods of making a nicotinamide ribofuranoside salt, in particular a crystalline nicotinamide ribofuranoside salt, via salt metathesis comprising subjecting nicotinamide ribofuranoside hydrogen malate or nicotinamide ribofuranoside hydrogen tartrate to salt metathesis to afford the nicotinamide ribofuranoside salt. In an alternative, acylated nicotinamide ribofuranoside hydrogen malate or acylated nicotinamide ribofuranoside hydrogen tartrate is subjected to salt metathesis followed by deacylation to afford the nicotinamide ribofuranoside salt.Type: ApplicationFiled: January 19, 2022Publication date: February 22, 2024Inventors: Urs Spitz, Aysel SOYDEMIR, Iris ZIMMERMANN, Günter SCHABERT
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Publication number: 20230107185Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: ApplicationFiled: August 18, 2022Publication date: April 6, 2023Inventors: Urs SPITZ, Günter SCHABERT, Aysel SOYDEMIR, Lukas WICK
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Patent number: 11584771Abstract: The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.Type: GrantFiled: April 1, 2022Date of Patent: February 21, 2023Assignee: BIOSYNTH AGInventors: Günter Schabert, Urs Spitz, Aysel Soydemir, Iris Zimmermann
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Patent number: 11447514Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: GrantFiled: May 17, 2019Date of Patent: September 20, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Urs Spitz, Günter Schabert, Aysel Soydemir, Lukas Wick
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Publication number: 20220251133Abstract: The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.Type: ApplicationFiled: April 1, 2022Publication date: August 11, 2022Inventors: Günter SCHABERT, Urs SPITZ, Aysel SOYDEMIR, Iris ZIMMERMANN
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Publication number: 20220135610Abstract: The present invention relates to a method of making nicotinamide ribofuranoside salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.Type: ApplicationFiled: January 14, 2022Publication date: May 5, 2022Inventors: Günter SCHABERT, Urs SPITZ, Aysel SOYDEMIR, Iris ZIMMERMANN
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Publication number: 20210206793Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: ApplicationFiled: May 17, 2019Publication date: July 8, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Urs SPITZ, Günter SCHABERT, Aysel SOYDEMIR, Lukas WICK
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Patent number: 9157917Abstract: A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.Type: GrantFiled: November 4, 2011Date of Patent: October 13, 2015Assignee: Biosynth AGInventors: Lukas Wick, Urs Spitz, Christophe Weymuth, Günter Schabert, Thomas Mayer, Alexander Bayer
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Patent number: 9127303Abstract: A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.Type: GrantFiled: June 8, 2012Date of Patent: September 8, 2015Assignee: Biosynth AGInventors: Urs Spitz, Lukas Wick, Gunter Schabert
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Patent number: 8940909Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.Type: GrantFiled: May 6, 2010Date of Patent: January 27, 2015Assignee: Biosynth AGInventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
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Publication number: 20140377783Abstract: A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.Type: ApplicationFiled: November 4, 2011Publication date: December 25, 2014Inventors: Lukas Wick, Urs Spitz, Christophe Weymuth, Günter Schabert, Thomas Mayer, Alexander Bayer
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Publication number: 20140212905Abstract: A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.Type: ApplicationFiled: June 8, 2012Publication date: July 31, 2014Inventors: Urs Spitz, Lukas Wick, Günter Schabert
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Publication number: 20120058503Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.Type: ApplicationFiled: May 6, 2010Publication date: March 8, 2012Applicant: Biosynth AGInventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
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Patent number: 6660494Abstract: Chromogenic 3-Indoxyl choline phosphate compounds of formula (I): wherein R is selected from the group consisting of hydrogen and C1-4 alkyl, such as methyl, ethyl, propyl and butyl while R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, carboxy, amino, amino substituted with one or two C1-4 alkyl groups, aminomethyl, hydroxy, C1-4 alkoxy, carboxyalkyl, and sulphonyl. These compounds are capable of being cleaved by lecithinase C leading to products which are calorimetrically detectable.Type: GrantFiled: December 19, 2001Date of Patent: December 9, 2003Assignee: Biosynth AGInventors: Günter Schabert, Lawrence Restaino, Elon W. Frampton
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Patent number: 6558917Abstract: Compounds of formula (I) in which R1, R2, R3, R4 and R5 are hydrogen atoms or chromogenic substituents and X is hydroxyl, OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl, or O−Me+ wherein Me+ is a cation derived from an organic or inorganic base; these compounds do not exhibit significant fluorescence but are capable of being cleaved by phosphatidyl-inositol-specific phospholipase C, an enzyme which is indicative of bacterial activity; the umbelliferyl moity resulting from such cleavage is a strong fluorogen thus providing effective test methods for various pathogenic bacteria, such as Listeria, Staphylococcus and Clostridium species. Also disclosed are plating media for detection of microorganisms that are capable of metabolic generation of a phosphatidyl inositol-specific phospholipase C (PI-PLC).Type: GrantFiled: May 17, 2002Date of Patent: May 6, 2003Assignee: Biosynth AGInventor: Günter Schabert
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Publication number: 20030032080Abstract: Compounds of formula (I) 1Type: ApplicationFiled: May 17, 2002Publication date: February 13, 2003Inventor: Gunter Schabert
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Publication number: 20020151725Abstract: Chromogenic 3-Indoxyl choline phosphate compounds of formula (I): 1Type: ApplicationFiled: December 19, 2001Publication date: October 17, 2002Applicant: BIOYNTH AGInventors: Gunter Schabert, Lawrence Restaino, Elon W. Frampton
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Patent number: 6416970Abstract: The invention provides compounds of formula (I) in which R1, R2, R3, R4 and R5 are independently selected from hydrogen and chromogenic substituents, and X is selected from the group consisting of hydroxyl; OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl; and O−Me+ wherein Me+ is a cation derived from an organic or inorganic base. A preferred species of formula (I) is 4-Methylumbelliferyl myo-inositol-1-phosphate and salts thereof with an organic or inorganic base. The invention also provides fluorogenic methods for detecting various pathogenic bacteria, e.g., Listeria, Staphylococcus and Clostridium species, using substrates containing at least one formula (I) compound. A kit for detecting a phosphatidyl-inositol-specific phospholipase C enzyme as an indication of bacterial activity is disclosed.Type: GrantFiled: September 19, 2000Date of Patent: July 9, 2002Assignee: Biosynth AGInventors: Günter Schabert, Lawrence Restaino
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Patent number: 6068988Abstract: A method of detecting a phosphatidylinositol-specific phospholipase C enzyme by means of a substrate which is cleaved by said enzyme and yields a dye when the chromophoric portion of the substrate is dimerized and oxidized; the invention teaches using in such method, as a novel substrate, a 3-indoxyl-myo-inositol-1-phosphate compound of formula (I) ##STR1## wherein R is selected from the group consisting of hydrogen and C.sub.1-4 alkyl, while R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are radicals selected from the group consisting of hydrogen, halogen, cyano, nitro, carboxy, amino, alkyl-substituted amino and sulphonyl; or of a salt of said formula I compound. The invention provides for a safe and sensitive method of detection of potentially pathogenic bacterial activity of such microbes as Bacillus cereus, B. Thuringiensis, Staphy lococcus aureus and various Listeria strains in potentially infected materials including physiological samples or consumable goods such as foods and beverages.Type: GrantFiled: December 10, 1997Date of Patent: May 30, 2000Assignee: Biosynth AGInventors: Gunter Schabert, Urs P. Spitz, Roland Humm
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Patent number: 6051391Abstract: A method of detecting a phosphatidylinositol-specific phospholipase C enzyme by means of a substrate which is cleaved by said enzyme and yields a dye when the chromophoric portion of the substrate is dimerized and oxidized; the invention teaches using in such method, as a novel substrate, a 3-indoxyl-myoinositol-1-phosphate compound of formula (I) ##STR1## wherein R is selected from the group consisting of hydrogen and C.sub.1-4 alkyl, while R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are radicals selected from the group consisting of hydrogen and chromogenic substituents, or of a salt of said formula I compound. The invention provides for a safe, sensitive and commercially viable detection of potentially pathogenic bacterial activity of such microbes as Bacillus cereus, B. Thuringiensis, Staphylococcus aureus and various Listeria strains in potentially infected materials including physiological samples or consumable goods such as foods and beverages.Type: GrantFiled: August 11, 1999Date of Patent: April 18, 2000Assignee: Biosynth AGInventors: Gunter Schabert, Urs P. Spitz, Roland Humm