Patents by Inventor Gunter Stempfer

Gunter Stempfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of recombinant polypeptides
    Patent number: 8426168
    Abstract: The present invention relates to the preparation of a recombinant polypeptide, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell. In particular, this invention relates to a process to enhance the extraction yield of the recombinant polypeptide from the periplasm before further downstream processing.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: April 23, 2013
    Assignee: Sandoz AG
    Inventors: Günter Stempfer, Norbert Palma
  • Process for the preparation of recombinant polypeptides
    Publication number: 20060269990
    Abstract: The present invention relates to the preparation of a recombinant polypeptide, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell. In particular, this invention relates to a process to enhance the extraction yield of said recombinant polypeptide from the periplasm before further downstream processing.
    Type: Application
    Filed: August 19, 2004
    Publication date: November 30, 2006
    Inventors: Gunter Stempfer, Norbert Palma
  • Process for the purification of recombinant polypeptides
    Publication number: 20060173167
    Abstract: This invention relates to a method for purification of a recombinant polypeptide of interest, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell.
    Type: Application
    Filed: August 12, 2004
    Publication date: August 3, 2006
    Inventors: Gunter Stempfer, Peter Alliger, Norbert Palma
  • Production of heterologous proteins using an Npro autoprotease of a pestivirus and inclusion bodies
    Patent number: 6936455
    Abstract: The present invention relates to a process for the recombinant production of a desired heterologous polypeptide with a clearly defined homogenous N-terminus in a bacteria host cell. A fusion comprising a peptide with the autoproteolytic activity of an autoprotease Npro of a pestivirus and the heterologous polypeptide is initially expressed in the form of cytoplasmic inclusion bodies in the host cell, the inclusion bodies are isolated and subsequently treated so that the desired heterologous polypeptide is cleaved autoproteolytically by the Npro activity of the fusion protein.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: August 30, 2005
    Assignee: Sandoz AG
    Inventors: Günter Stempfer, Jörg Windisch, Franz Knauseder
  • Production of proteins
    Publication number: 20050186564
    Abstract: The present invention relates to a process for the recombinant production of a desired heterologous polypeptide with a clearly defined homogenous N-terminus in a bacterial host cell. A fusion protein comprising a peptide with the autoproteolytic activity of an autoprotease Npro of a pestivirus and the heterologous polypeptide is initially expressed in the form of cytoplasmic inclusion bodies in the host cell, the inclusion bodies are isolated and subsequently treated so that the desired heterologous polypeptide is cleaved autoproteolytically by the Npro activity of the fusion protein.
    Type: Application
    Filed: April 5, 2005
    Publication date: August 25, 2005
    Inventors: Gunter Stempfer, Jorg Windisch, Franz Knauseder