Patents by Inventor Gunter Thoma
Gunter Thoma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4791122Abstract: 5-Aryl-1,4-dihydropyridines of the formula ##STR1## in which Rrepresents cycloalkyl,heteroaryl oraryl which is optionally substituted by at least one substituent independently selected from the group consisting of halogen, nitro, hydroxyl, amino, carboxyl, alkoxycarbonyl, cyano, acyl, acyloxy, acylthio, by alkyl, alkyloxy, alkylthio or alkylsulphonyl, each of which is optionally substituted by one or more halogens, by aryl which is optionally substituted by alkyl, alkoxy, halogen or nitro, or optionally by the group --Z--CH.sub.2 --R.sup.4,whereZ represents oxygen or sulphur, andR.sup.4represents cycloalkyl,heteroaryl oraryl which is optionally substituted by halogen, cyano, nitro, hydroxyl, carboxyl, alkoxycarbonyl or by alkyl or alkoxy, each of which is optionally substituted by one or more halogens,R.sup.1 and R.sup.2are identical or different andrepresent straight-chain or branched alkyl which is optionally substituted by aryl, carboxyl, alkoxycarbonyl or by hydroxyl,R.sup.Type: GrantFiled: January 8, 1986Date of Patent: December 13, 1988Assignee: Bayer AktiengesellschaftInventors: Jurgen Stoltefuss, Rainer Gross, Matthias Schramm, Gunter Thomas, Michael Kayser, Bernd Pelster
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Patent number: 4772611Abstract: Novel cardioactive compounds of the formula ##STR1## in which R.sup.1 is alkyl, aryl or heterocyclic, preferably substituted phenyl,R.sup.2 is alkyl, preferably methyl,R.sup.3 is hydrogen, halogen, acyloxy or alkyl, preferably hydrogen, andR.sup.4 is phenyl, carbalkoxy or together with R.sup.3 forms a ring, preferably carbalkoxy,are produced by reducing the corresponding nitro compounds.Type: GrantFiled: April 28, 1987Date of Patent: September 20, 1988Assignee: Bayer AktiengesellschaftInventors: Jurgen Stoltefuss, Fred R. Heiker, Martin Bechem, Rainer Gross, Michael Kayser, Matthias Schramm, Gunter Thomas
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Patent number: 4772612Abstract: Novel circulation active dihydropyridines of the formula ##STR1## in which X is CO, SO.sub.2 or CONH,R.sup.4 is H, OH, alkyl, halogen, acyloxy, alkoxyalkoxy, aralkyloxy, or together with R.sup.5 forms a heterocyclic ring, andthe other radicals are conventional in the dihydropyridine art,and pharmaceutically acceptable salts thereof.Type: GrantFiled: June 3, 1986Date of Patent: September 20, 1988Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Jurgen Stoltefuss, Gerhard Franckowiak, Rainer Gross, Matthias Schramm, Gunter Thomas
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Patent number: 4764516Abstract: Pure enantiomers of 5-nitrodihydropyridine of the formula ##STR1## are mixed, wherein one of the enantiomers has a high vasodilative action and a low negative inotropic activity on heart muscle, the other enantiomer has a low vasoconstrictive action and a high positive inotropic activity on heart muscle, the mixture being high in vasodilative activity and in positive inotropic activity on heart muscle.Type: GrantFiled: December 6, 1985Date of Patent: August 16, 1988Assignee: Bayer AktiengesellschaftInventors: Gerhard Franckowiak, Rolf Grosser, Gunter Thomas, Matthias Schramm, Rainer Gross
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Patent number: 4762853Abstract: 1-Oxo-1,3,4,7-tetrahydrobenzofuranes of the formula ##STR1## in which X is O or S,R is optionally substituted phenyl or heteroaryl,R.sup.1 is OH, monoalkylamino or dialkylamino, andR.sup.2 is an acyl or esterified carboxy radical,or pharmacologically acceptable salts thereof, which are active in circulation, e.g. they increase myocardial contractility, increase the flow of Ca.sup.2+ into the cell, increase blood pressure, reduce blood sugar, reduce swelling of mucous membranes and affect the salt and/or fluid balance.Type: GrantFiled: October 10, 1986Date of Patent: August 9, 1988Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4710501Abstract: Novel compounds of the formula ##STR1## in which R.sup.2 is hydrogen or a substituent, andR.sup.1 is optionally substituted alkyl or alkenyl,exhibit positive inotropic activity on the cardiac muscle, intensifying the contraction power.Type: GrantFiled: May 13, 1986Date of Patent: December 1, 1987Assignee: Bayer AktiengesellschaftInventors: Gerhard Franckowiak, Martin Bechem, Rainer Gross, Michael Kayser, Matthias Schramm, Gunter Thomas
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Patent number: 4707479Abstract: 1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the blood-sugar level and the circulation and as coronary therapeutic agents and anti-arrhythmic agents.Type: GrantFiled: December 5, 1985Date of Patent: November 17, 1987Assignee: Bayer AktiengesellschaftInventors: Horst Meyer, Gerhard Franckowiak, Ulrich Rosentreter, Rainer Gross, Gunter Thomas, Matthias Schramm, Michael Kayser, Friedel Seuter, Elisabeth Perzborn, Martin Bechem
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Patent number: 4647568Abstract: Hydroxytetrahydropyridinelactones of the formula ##STR1## in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, quinolyl, isoquinolyl, indolyl, benzimidazolyl, quinazolyl, quinoxalyl, thionaphthenyl, isothionaphthenyl, chromonyl, thiochromonyl, chromenyl, thiochromenyl, benzoxadiazolyl or benzthiadiazolyl radical, and the stated radicals may carry 1 to 3 identical or different substituents from the group comprising C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkinyl, C.sub.1 -C.sub.20 -alkoxy, fluorine, chlorine, bromine, iodine, trifluoromethyl, monofluoro-C.sub.1 -C.sub.10 -alkoxy, polyfluoro-C.sub.1 -C.sub.10 -alkoxy, hydroxyl, amino, mono-C.sub.1 -C.sub.10 -alkylamino, di-C.sub.1 -C.sub.10 -alkylamino, nitro, cyano, azido, carboxyl, carb-C.sub.1 -C.sub.10 -alkoxy, carboxamido, sulphonamido, SO.sub.Type: GrantFiled: November 20, 1984Date of Patent: March 3, 1987Assignee: Bayer AktiengesellschaftInventors: Klaus Gorlitzer, Ulrich Bartke, Siegfried Goldmann, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4645775Abstract: Novel 3-nitro-dihydropyridine derivatives of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## Z is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring form the ring ##STR3## X is oxygen or sulphur, A is a hydrocarbon radical with up to 12 C atoms which optionally contains one or two identical or different chain members from the group comprising O, S and CO and/or which is optionally substituted by hydroxyl or aliphatic acyloxy with up to 4 C atoms,R.sub.3 is --O--COR.sub.6, --S--CO--R.sub.6, SH, OH , NH.sub.2, ##STR4## NH--COR.sub.6, COOR.sub.6, NR.sub.7 R.sub.8 or CONR.sub.7 R.Type: GrantFiled: May 15, 1985Date of Patent: February 24, 1987Assignee: Bayer AktiengesellschaftInventors: Jurgen Stoltefuss, Fred R. Heiker, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4642310Abstract: Tetrahydrothienopyridines of the formula ##STR1## in which R is optionally substituted aryl or heterocyclyl,R.sup.1 is an organic radical, andR.sup.2, R.sup.3 and R.sup.4 each independently is hydrogen or an organic radical, or pharmaceutically acceptable salts thereof, which are coronary active, hypotensive, anti-diabetic and salt balance restoring.Type: GrantFiled: March 28, 1985Date of Patent: February 10, 1987Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4628107Abstract: Novel chromone-8-aldehydes and thiochromone-8-aldehydes, useful in making pharmaceutically active dihydropyridines, of the formula ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1 -C.sub.10 aliphatic hydrocarbon radical, a C.sub.1 -C.sub.10 alkyl carboxylate, or an aromatic or heteroaromatic ring which optionally has 1-5 identical or different halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, cyano, hydroxyl, nitro, C.sub.1 -C.sub.5 -monofluoroalkyl or polyfluoroalkyl, C.sub.1 -C.sub.5 monofluoroalkoxy or polyfluoroalkoxy, C.sub.1 -C.sub.6 monofluoroalkylthio or polyfluoroalkylthio, amino, C.sub.1 -C.sub.5 -monoalkylamino or C.sub.1 -C.sub.5 dialkylamino substituents,R.sub.2 represents hydrogen or 1 to 3 halogen atoms, A represents a single bond, a C.sub.1 -C.sub.20 alkylene chain or a C.sub.2 -C.sub.Type: GrantFiled: June 28, 1985Date of Patent: December 9, 1986Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4621093Abstract: 4-(Nitrophenyl)-1,2,3,4-tetrahydropyridines of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and each represent hydrogen, phenyl or a straight-chain or branched alkyl radical which is optionally substituted by halogen or alkoxy,R.sub.3 represents a straight-chain or branched alkyl radical which is optionally substituted by alkoxy, halogen, alkylamino or aryl,X represents a single bond, an oxygen atom, a sulphur atom or the NH group andY denotes either the nitrile group or the radical ##STR2## wherein X' corresponds to the definition of X and can either be identical to X or different from X, andR.sub.4 corresponds to the definition of R.sub.3 and can be either identical to R.sub.3 or different from R.sub.3,or physiologically acceptable salts thereof, which are active on the circulation system, for example as vasodilators.Type: GrantFiled: April 8, 1985Date of Patent: November 4, 1986Assignee: Bayer AktiengesellschaftInventors: Rosentreter Ulrich, Gunter Thomas, Andreas Knorr
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Patent number: 4585772Abstract: The invention relates to pharmaceutical compositions containing active ingredients of Formula (I) and methods for the use of said compositions to treat cardiac insufficiencies. Also included in the invention are methods of the manufacture of said active ingredients of Formula (I). The invention includes, additionally, compounds of Formula (I).Type: GrantFiled: July 11, 1983Date of Patent: April 29, 1986Assignee: Bayer AktiengesellschaftInventors: Bodo Junge, Siegfried Goldmann, Gunter Thomas, Bernward Garthoff
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Patent number: 4582840Abstract: A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.Type: GrantFiled: April 25, 1985Date of Patent: April 15, 1986Assignee: Bayer AktiengesellschaftInventors: Bernward Garthoff, Stanislav Kazda, Andreas Knorr, Gunter Thomas
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Patent number: 4555512Abstract: Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.5 and R.sup.6 can be hydrogen or various halogen or organic radicals,R.sup.4 is an optionally substituted hydrocarbon radical,A is a direct bond, a C.sub.1 -C.sub.20 -alkylene chain or a C.sub.2 -C.sub.20 -alkenylene chain, which chains are optionally interrupted by O or SX is O or S, andY is a direct bond, O, S, --NH--or--N-alkyl with 1 to 8 C atomsor a pharmaceutically acceptable salt,are useful as cardiotonic agents for improving heart contractility, antihypotonic agents, for lowering the blood sugar level, for detumescing mucous membranes and for influencing the salt and/or liquid balance.Type: GrantFiled: March 14, 1984Date of Patent: November 26, 1985Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Friedrich Bossert, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4540789Abstract: Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 can be hydrogen or various halogen or organic radicals,R.sup.4 is an optionally substituted hydrocarbon radical,A is a direct bond, an alkylene chain with 1 to 20 C atoms or an alkenylene chain with 2 to 20 atoms, the chains being optionally interrupted by O or S,X is O or S andY is a direct bond, O, S, -NH- or -N- alkyl with 1 to 8 C atoms,or a pharmaceutically acceptable salt thereof, are useful as cardiotonic agents for improving heart contractility, antihypotonic agents, for lowering the blood sugar level, for detumescing mucous membranes and for influencing the salt and liquid balance.Type: GrantFiled: March 14, 1984Date of Patent: September 10, 1985Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4540684Abstract: A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, andR.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.Type: GrantFiled: May 18, 1984Date of Patent: September 10, 1985Assignee: Bayer AktiengesellschaftInventors: Jurgen Stoltefuss, Gerhard Franckowiak, Horst Boshagen, Siegfried Goldmann, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4537881Abstract: Novel 1,4-dihydropyridines of the fomula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## in which Z is oxygen or sulphur, andR.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring, form the ring ##STR3## X is oxygen, sulphur or the radical NR.sub.6, R.sub.6 is a C.sub.1 -C.sub.6 -alkyl group,A is a C.sub.2 -C.sub.10 -alkylene group, it being necessary that at least two C atoms are located in the alkylene chain which connects the carbonyloxy group to X, andR.sub.Type: GrantFiled: July 3, 1984Date of Patent: August 27, 1985Assignee: Bayer AktiengesellschaftInventors: Fred R. Heiker, Jurgen Stoltefuss, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
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Patent number: 4532248Abstract: 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.Type: GrantFiled: July 14, 1982Date of Patent: July 30, 1985Assignee: Bayer AktiengesellschaftInventors: Gerhard Franckowiak, Horst Boshagen, Friedrich Bossert, Siegfried Goldmann, Horst Meyer, Egbert Wehinger, Jurgen Stoltefuss, Matthias Schramm, Gunter Thomas, Robertson Towart
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Patent number: 4492703Abstract: 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals,R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S or SO, andB is a direct bond or alkylene,or pharmaceutically acceptable addition salts thereof exhibit hypotensive, vasodilating and coronary activities.Type: GrantFiled: February 22, 1983Date of Patent: January 8, 1985Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Horst Boshagen, Jurgen Stoltefuss, Matthias Schramm, Gunter Thomas, Stanislav Kazda