Patents by Inventor Gunter Weimann
Gunter Weimann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5108913Abstract: .alpha.-Amylase is determined by the enzymatic splitting of an .alpha.-amylase substrate and measurement of a fission product, wherein there is used as a substrate a maltoheptaose compound of the formula ##STR1## wherein R is a glucoside, phenylglucoside, mononitrophenylglucoside, dinitrophenylglucoside, sorbitol or gluconic acid group. Reagents comprising such a substrate and a system for the determination of a fission product formed from the amylase substrate by .alpha.-amylase, are also provided. A process for the preparation of a maltoheptaose will Bacillus macerans amylase, free of p-nitrophenyl-alpha-glucoside splitting activity is disclosed.Type: GrantFiled: June 27, 1990Date of Patent: April 28, 1992Assignee: Boehringer Mannheim GmbHInventors: Elli Rauscher, Ulrich Neumann, August W. Wahlefeld, Alexander Hagen, Wolfgang Gruber, Joachim Ziegenhorn, Eugen Schaich, Ulfert Deneke, Michal Gerhard, Gunter Weimann
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Patent number: 4544631Abstract: .alpha.-Amylase is determined by the enzymatic splitting of an .alpha.-amylase substrate and measurement of a fission product, wherein there is used as a substrate a maltoheptaose compound of the formula ##STR1## wherein R is a glucoside, phenylglucoside, mononitrophenylglucoside, dinitrophenylglucoside, sorbitol or gluconic acid group. Reagents comprising such a substrate and a system for the determination of a fission product formed from the amylase substrate by .alpha.-amylase, are also provided.Type: GrantFiled: October 16, 1981Date of Patent: October 1, 1985Assignee: Boehringer Mannheim GmbHInventors: Elli Rauscher, Ulrich Neumann, August W. Wahlefeld, Alexander Hagen, Wolfgang Gruber, Joachim Ziegenhorn, Eugen Schaich, Ulfert Deneke, Gerhard Michal, Gunter Weimann
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Patent number: 4492659Abstract: The present invention provides phospholipids of the general formula: ##STR1## wherein X is a valency bond, an oxygen or sulphur atom or a sulfonyl, sulfinyl, phenylene, cycloaklylene, carbonylamino, aminocarbonyl, ureido or carbonyl group, R.sub.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, carbalkoxy or phenyl, R.sub.2 is a straight-chained or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulphinyl, alkanesulphonyl, carbalkoxy or phenyl, Y is an oxygen atom or a --O--CO--O--, --O--CO--NH-- or --O--CS--NH-- group, R.sub.Type: GrantFiled: July 7, 1982Date of Patent: January 8, 1985Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall, Gunter Weimann, Uwe Bicker, Wulf Pahlke
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Patent number: 4444766Abstract: Sulfur-containing phospholipid compounds of the formula ##STR1## pharmaceutical compositions having anti-tumor activity which include said phospholipid compounds, and the method of use for combating tumors, of said phospholipid compounds.Type: GrantFiled: October 16, 1981Date of Patent: April 24, 1984Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall, Gunter Weimann, Uwe Bicker, Wulf Pahlke
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Patent number: 4436828Abstract: New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).Type: GrantFiled: October 27, 1980Date of Patent: March 13, 1984Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Hans-Ralf Linke, Klaus Stellner, Gunter Weimann
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Patent number: 4337310Abstract: Method for determining .alpha.-amylase by incubating with a starch substrate, wherein the substrate is based upon particulate starch derivatized with detectable groups for the determination of .alpha.-amylase, the substrate consisting of superficially cross-linked starch or amylose grains having a regulated, reduced swellability, said grains having a diameter of from 0.01 to 0.20 mm; these grains are prepared by suspending non-swollen grains in a solution with only enough cross-linking agent to achieve superficial cross-linking and then derivatizing the grains with the detectable groups for the determination of .alpha.-amylase.Type: GrantFiled: September 8, 1980Date of Patent: June 29, 1982Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Elli Rauscher, Gunter Weimann, August W. Wahlefeld, Wolfgang Gruber
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Patent number: 4268628Abstract: Novel method for the determination of .alpha.-amylase which method comprises contacting a sample suspected of containing .alpha.-amylase with a starch derivative carrying a substituent capable of dyestuff-forming coupling; separating from the resulting starch-containing phase the low molecular weight soluble fission products formed by splitting of said starch derivative by .alpha.-amylase; coupling the said couplable substituent with another dyestuff forming component; and measuring the dyestuff so formed as a measure of the initial .alpha.-amylase content.Type: GrantFiled: March 19, 1979Date of Patent: May 19, 1981Assignee: Boehringer Mannheim GmbHInventors: Sigmar Klose, Hans-Georg Batz, Michael Stoltz, Alexander Hagen, Gunter Weimann
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Patent number: 4248786Abstract: New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is -O-CH.sub.2 -CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;n is a whole number of from 2 to 7;m is 1, 2, 3 or 4,R is hydrogen, methyl, or cyanide; andR' is methyl or ethyl.have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.Type: GrantFiled: March 8, 1979Date of Patent: February 3, 1981Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Jurgen Horn, Klaus Stellner, Josef Maier, Michael Nelboeck-Hochstetter, Gunter Weimann
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Patent number: 4202873Abstract: Novel alkylolamides of iodizable amino acids of the formula ##STR1## wherein, R.sup.1 is hydroxybenzyl, dihydroxybenzyl or imidazol-4-yl-methyl andR.sup.2 is monohydroxy-alkyl of 1 or 2 carbon atoms or dihydroxy-alkyl of up to 4 carbon atoms,and the water-soluble salts thereof are provided; these materials are useful as components of radioiodizable immune test reagents.Type: GrantFiled: March 30, 1977Date of Patent: May 13, 1980Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Klaus Stellner, Hans-Ralf Linke, Gunter Weimann
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Patent number: 4184848Abstract: An agent for the elimination of turbidity in serum, especially in serum samples wherein photometric measurements are to be made, consisting essentially of one or more mono- or di-esters of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said esters having an HLB value of from 8 to 12.8.Type: GrantFiled: September 23, 1977Date of Patent: January 22, 1980Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Brigitte Draeger, August W. Wahlefeld, Gunter Weimann, Wolfgang Gruber
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Patent number: 4155914Abstract: New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is --O--CH.sub.2 --CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;N is a whole number of from 2 to 7;M is 1, 2, 3 or 4,R is hydrogen, methyl, or cyanide; andR' is methyl or ethyl;Have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.Type: GrantFiled: July 13, 1977Date of Patent: May 22, 1979Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Jurgen Horn, Klaus Stellner, Josef Maier, Michael Nelboeck-Hochstetter, Gunter Weimann
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Patent number: 4148994Abstract: Crystalline salts of .beta.-nicotinamide-adenine-dinucleotide (.beta.-NAD), particularly alkali metal salts thereof are prepared in good yield and high quality to provide an analytically useful .beta.-NAD form.Type: GrantFiled: December 27, 1976Date of Patent: April 10, 1979Assignee: Boehringer Mannheim GmbHInventors: Klaus Muhlegger, Gunter Weimann, Michael Nelboeck-Hochstetter
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Patent number: 4133949Abstract: New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5. are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).Type: GrantFiled: August 16, 1976Date of Patent: January 9, 1979Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Hans-Ralf Linke, Klaus Stellner, Gunter Weimann
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Patent number: 4101381Abstract: In a conventional method for the quantitative determination of substances, particularly in serum, which, by action of an oxidase thereon, combine with oxygen to form hydrogen peroxide and wherein the hydrogen peroxide formed is converted, in the presence of methanol and catalase, to formaldehyde, the formaldehyde is reacted with hydrazone in the presence of ferric chloride, and the dye thus formed is determined photometrically, the improvement comprising using as the hydrazone, 3-methyl-2-sulfonylbenzothiazolone-hydrazone; use of this hydrazone results in the formation of a very easily soluble dye and is suited for use in automatic analyzers.Type: GrantFiled: December 27, 1976Date of Patent: July 18, 1978Assignee: Boehringer Mannheim GmbHInventors: Sigmar Klose, Ulfert Deneke, Erich Haid, Gunter Weimann
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Patent number: 4081329Abstract: Carrier-bound macromolecular compounds, especially bioactive macromolecular compounds, are produced by reacting a macromolecular compound A with a coupling compound B containing at least one reactive function capable of coupling with compound A and at least one further reactive function capable of polymerization, adding to the resulting coupled reaction product AB an unswollen molecular sieve material having cross-linking sufficient to exclude penetration by compound A, and polymerizing the polymerizable group of the coupled product AB in the molecular sieve material to form a polymer body in the molecular sieve material and fix compound A on the surface of the molecular sieve material. Compound A can be, e.g., an enzyme, antibody or hormone, and coupling compound B typically contains, as the coupable function, an alkylation or acylation group such as oxirane, ethyleneimine, halide, acid halide, azide or anhydride groups, and, as the polymerizable function, a carbon-carbon or carbon-oxygen double bond.Type: GrantFiled: February 5, 1976Date of Patent: March 28, 1978Assignee: Boehringer Mannheim GmbHInventors: Dieter Jaworek, Karl-Heinz Botsch, Gunter Weimann, Michael Nelbock-Hochstetter, Helmut Determann
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Patent number: 4049702Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##STR1## wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyl-transpeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycylglycine and determining the liberation of the resulting p-nitro-aniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: June 23, 1975Date of Patent: September 20, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann
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Patent number: 3986931Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##SPC1##Wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyltranspeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycyl-glycine and determining the liberation of the resulting p-nitroaniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: August 4, 1975Date of Patent: October 19, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann
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Patent number: 3979447Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##SPC1##Wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyltranspeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycylglycine and determining the liberation of the resulting p-nitroaniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: November 27, 1973Date of Patent: September 7, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann
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Patent number: 3951744Abstract: NADP-dependent dehydrogenases are separated and purified by subjecting mixtures containing it to affinity chromatography using as the affinity chromatography material a nucleotide with a phosphate group in the 2'- or 3'-position, bound to a solid carrier.Type: GrantFiled: July 16, 1974Date of Patent: April 20, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Albert Roder, Klaus Beaucamp, Gunter Weimann, Walter Schneider, Klaus Muhlegger