Abstract: This invention relates to systems and test strips for detecting the photosynthesis-inhibitory activity of substances by providing cells or cell parts with an intact photosystem, introducing the cells or cell parts into a planar layer, applying the test substance to the planar layer or into the planar layer, excitation of the luminescence of the cells or cell parts in the planar layer by an excitation light source, measuring the luminescence of the cells or the cell parts in the planar layer by means of a detector, and associating the detector signal with the degree of photosynthesis inhibition.

Abstract: The invention relates to a diffusion-controlling sensor layer for detecting the biological effect of substances consisting of a diffusion-controlling matrix and sensors suspended therein. The invention further comprises a method and an apparatus for the location-dependent detection of the biological effect of substances using the sensor layer according to the invention (“imaging” of the spatial distribution of biological activity). A further embodiment of the method according to the invention relates to the coupling of investigations of the biological activity of substances with chromatographic and electrophoretic separation techniques so that biologically active individual substances can be identified directly in mixtures. An additional embodiment of the method according to the invention comprises the direct combination of the detection of the effect via sensor layers with chromatographic and electrophoretic separation techniques which are in turn coupled to spectroscopic techniques.

Abstract: This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting the change in luminescence of the suspension of microorganisms, and e) stimulating the luminescence of the microorganisms before or during detection, and/or f) extending the period of luminescence of the microorganisms by employing substances for regulating and extending the period of luminescence of the microorganisms.

Abstract: The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns.

Abstract: The novel 2-oxyamino-1-cyclopentene-1-nitriles of the formula (I) in which the substituents R1 and R2 are as defined in the description are highly suitable for protecting industrial materials against infestation and destruction by microorganisms.

Abstract: The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a ?N—(O, NH or NRx)—Ry moiety in the C-9 position, to methods for their manufacture, and to their use for controlling animal pests.

Abstract: The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns.

Abstract: The present invention relates to a method for identifying macrocylic polyketides by a biosensor system and to components of this biosensor system.

Abstract: Methods, system and test strip for detecting the photosynthesis-inhibitory activity of substances by providing cells or cell parts with an intact photosystem, introducing the cells or cell parts into a planar layer, applying the test substance to the planar layer or into the planar layer, excitation of the luminescence of the cells or cell parts in the planar layer by an excitation light source, measuring the luminescence of the cells or the cell parts in the planar layer by means of a detector, and associating the detector signal with the degree of photosynthetic inhibition.

Abstract: The method of producing luminescent bacteria is based on the transfer of genetic information for biological luminescence to obligate chemolithoautotrophic nitrifying microorganisms. In particular, luciferase DNA or a luciferase-beta-galactosidase transcription fusion is transferred into ammonia-oxidizing bacteria with the aid of plasmid- or transposon vector systems. The bioluminescent nitrification microorganisms, particularly Nitrosomonas strains modified by genetic engineering, are used in order to identify specific inhibitors during nitrification processes, the viability of these microorganisms being determined by measuring the decrease in luminescence. A particularly important application is that inhibitors in a nitrifying biological sewage treatment plant can be detected in this manner.