Patents by Inventor Gunther Jung

Gunther Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6982315
    Abstract: The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine component in the form of a compound containing at least one primary or secondary amino group, and its use.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: January 3, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Rudolph, G√ľnther Jung, Bernd Thern
  • Publication number: 20020193594
    Abstract: The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine component in the form of a compound containing at least one primary or secondary amino group, and its use.
    Type: Application
    Filed: March 27, 2002
    Publication date: December 19, 2002
    Inventors: Joachim Rudolph, Gunther Jung, Bernd Thern
  • Patent number: 6080719
    Abstract: The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in which A, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: June 27, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Birgit Jordan, Jochen Knolle, Leander Lauffer, Susanne Feiertag, Karl-Heinz Wiesmuller, Gunther Jung
  • Patent number: 6074650
    Abstract: According to certain embodiments, the invention relates to an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a protein of a virus, a bacterium, a parasite or a tumor antigen. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Jung, Karl-Heinz Wiesmuller, Hans-Georg Rammensee, Hansjorg Schild, Karl Deres
  • Patent number: 6024964
    Abstract: According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 15, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Jung, Karl-Heinz Wiesmuller, Jorg Metzger, Hans-Jorg Buhring, Gerhard Becker, Wolfgang Bessler
  • Patent number: 5962253
    Abstract: A method is described for oxidatively decarboxylating a peptide, comprising combining a peptide with EpiD, wherein the peptide comprises at its carboxy terminus the amino acid sequence X.sub.1 X.sub.2 X.sub.3 X.sub.4 X.sub.5 X.sub.6 C, wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are any one of the twenty common amino acids, X.sub.5 is Tyr, Val, Met, Leu, Ile, Phe or Trp, and X.sub.6 is Cys, Ala, Ser, Val, or Thr, whereby the oxidative decarboxylation of the peptide occurs.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: October 5, 1999
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Kupke, Friedrich Gotz, Christoph Kempter, Gunther Jung
  • Patent number: 5869447
    Abstract: The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in whichA, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: February 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Birgit Jordan, Jochen Knolle, Leander Lauffer, Susanne Feiertag, Karl-Heinz Wiesmuller, Gunther Jung
  • Patent number: 5843709
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner
  • Patent number: 5837485
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: November 17, 1998
    Assignee: Dr. Karl Tomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner
  • Patent number: 5747269
    Abstract: The present invention concerns a method for the determination of allele-specific peptide motifs on molecules of the major histocompatibility complex (MHC) of classes I and II as well as the peptide motifs which are obtainable by the method according to the invention. In addition the use of the peptide motifs according to the invention for the production of a diagnostic or therapeutic agent is disclosed.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: May 5, 1998
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Hans-Georg Rammensee, Kirsten Falk, Olaf Rotzschke, Stefan Stevanovic, Gunther Jung
  • Patent number: 5700910
    Abstract: N-Acyl-S-(2-hydroxyalkyl)cysteines, their preparation and their use as intermediates for the preparation of synthetic immunoadjuvants and synthetic vaccines.Compounds of the formula I ##STR1## in which the substances X, Y, R, R.sup.1 and R.sup.2 have the meanings mentioned, are suitable for the preparation of lipopeptides and lipoamino acids.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jorg Metzger, Karl-Heinz Wiesmuller, Gunther Jung
  • Patent number: 5231013
    Abstract: A new polycyclic peptide antibiotic termed gallidermin is disclosed and described, together with a process for producing such antibiotic by fermination of a new microorganism, Staphylococcus gallinarum (DSM 4616).
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: July 27, 1993
    Inventors: Gunther Jung, Roland Kellner, Hans Zahner, Friedrich Gotz, Thomas Horner, Rolf G. Werner, Hermann Allgaier
  • Patent number: 5095139
    Abstract: Rhizocticines of the formula ##STR1## in which X represents hydrogen or a hydrophobic amino acid radical and Y represents a basic amino acid radical, the C2 atoms of the amino acid radicals having the L-configuration, and protected derivatives and salts thereof.The compounds are obtained from culture broths of Bacillus subtilis or synthetically and have especially fungicidal action.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: March 10, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Loeffler, Martin Kugler, Gunther Jung, Armin Kern, Claudius Rapp
  • Patent number: 4376760
    Abstract: The tridecapeptide of the formulaH-Met-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-OHand the use thereof as a hapten, tracer or antibody.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: March 15, 1983
    Assignee: Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
    Inventors: Gunther Jung, Hans Bruckner, Peter Swetly, Gerhard Bozler
  • Patent number: 4370312
    Abstract: The decapeptide of the formulaH-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-OHand the use thereof as hapten, tracer or antibody.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: January 25, 1983
    Assignee: Dr. Karl Thomae Gesellshaft mit beschrankter Haftung
    Inventors: Gunther Jung, Hans Bruckner, Peter Swetly, Gerhard Bozler