Patents by Inventor Gunther Kinast
Gunther Kinast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5242903Abstract: Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Z denotes oxygen, sulphur or the methylene grouprepresents a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 --NR2R.sub.3and physiologically acceptable salts thereof.Type: GrantFiled: October 2, 1991Date of Patent: September 7, 1993Assignee: Bayer AktiengesellschaftInventors: Wolfgang Bender, Gunther Kinast, Andreas Knorr, Johannes-Peter Stasch
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Patent number: 5095006Abstract: Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Q1 denotes oxygen, sulphur or the methylene grouprepresent a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 NR.sup.2 R.sup.3and physiologically acceptable salts thereof.Type: GrantFiled: July 13, 1990Date of Patent: March 10, 1992Assignee: Bayer AktiengesellschaftInventors: Wolfgang Bender, Gunther Kinast, Andreas Knorr, Johannes-Peter Stasch
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Patent number: 5051407Abstract: A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a 2-hydroxymethylene-3,4,5-trihydroxypiperidine.Type: GrantFiled: October 19, 1988Date of Patent: September 24, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Bodo Junge, Gunther Kinast, Matthias Schuller, Jurgen Stoltefuss, Arnold Paessens
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Patent number: 4871747Abstract: A 3-amino-4,5-dihydroxy-piperidine compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl having up to 8 carbon atoms, aralkyl having 7 to 14 carbon atoms, or represents a group of the formula ##STR2## R.sup.4 denotes straight-chain or branched alkyl having up to 8 carbon atoms, straight-chain or branched alkoxy having up to 8 carbon atoms, or aralkoxy having up to 10 carbon atoms, andR.sup.2 and R.sup.3 represent hydrogen or represent the group NHR.sup.5,R.sup.5 having the same meaning as R.sup.1 and being identical to or different from the latter,with the proviso that, in every case, one substituent of R.sup.2 or R.sup.3 represents hydrogen and the other substituent of R.sup.2 or R.sup.3 represents NHR.sup.5, and physiologically acceptable salts thereof. Such compound is useful to treat prediabetes, gastritis, constipation, caries, atherosclerosis, obesity, diabetes and hyperlipoproteinaemia.Type: GrantFiled: December 3, 1986Date of Patent: October 3, 1989Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Matthias Schuller, Theo Schroder
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Patent number: 4808622Abstract: Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.Type: GrantFiled: January 7, 1987Date of Patent: February 28, 1989Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Eckhard Schwenner, Stanislav Kazda, Andreas Knorr, Michael Kayser
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Patent number: 4754031Abstract: A process for the preparation of a cephalosporin of the formula ##STR1## in which R.sup.1 is an aliphatic or cycloaliphatic radical with up to 6 carbon atoms, andA is a pyridinium radical or a radical of the formula ##STR2## comprising reacting an acid of the formula ##STR3## with methanesulphonyl chloride to form an anhydride of the formula ##STR4## and reacting the anhydride with a 7-aminocephalosporanate of the formula ##STR5## The reaction proceeds smoothly and in high yield.Type: GrantFiled: May 6, 1985Date of Patent: June 28, 1988Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Gunther Kinast
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Patent number: 4626535Abstract: Novel antibacterially active cephalosporins of the formula ##STR1## in which R.sup.1 denotes hydrogen, optionally substituted alkyl, a substituted or unsubstituted phenyl ring, a polycyclic aromatic ring or an optionally substituted heterocyclic 5- or 6-member ring having 1-4 heteroatoms,R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkenyl, halogen, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, hydroxymethyl, formyloxymethyl, C.sub.1 -C.sub.4 -alkylcarbonyloxymethyl, aminocarbonyloxymethyl, pyridiniummethyl, 4-carbamoylpyridiniummethyl, 4-sulphonylethylpyridiniummethyl, 4-carboxylmethylpyridiniummethyl or heterocyclylthiomethyl, heterocyclyl representing a radical of the formula ##STR2## wherein R.sup.8 denotes hydrogen, methyl, 2-dimethylaminoethyl, carboxymethyl, sulphomethyl, carboxyethyl or sulphoethyl andR.sup.9 denotes hydrogen or methyl,or pharmaceutically tolerated salts or esters thereof.Type: GrantFiled: December 30, 1983Date of Patent: December 2, 1986Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Michael Boberg, Gunther Kinast, Karl G. Metzger, Wilfried Schrock, Hans-Joachim Zeiler
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Patent number: 4500716Abstract: Highly active substantially pure Z-isomers of cephalosporins are produced by the following synthesis: ##STR1## in which R.sup.1, R.sup.4 and R.sup.5 ae various organic radicals,R.sup.2 is alkoxycarbonyl,Y is Cl, Br or --O--SO.sub.2 --R.sup.5, andX is a conventional cephalosporin substituent.Many of the intermediates are new, especially in pure Z-form.Type: GrantFiled: November 1, 1982Date of Patent: February 19, 1985Assignee: Bayer AktiengesellschaftInventor: Gunther Kinast
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Patent number: 4489076Abstract: Antibacterially active cephalosporins of the formula ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.6 -alkyl, phenyl or halogen-substituted phenyl, andR.sup.2 and R.sup.3, which can be identical or different, denote H, C.sub.1 -C.sub.4 -alkyl, chlorine, bromine, carbamoyl or N-C.sub.1 -C.sub.4 -alkylcarbamoyl.Type: GrantFiled: October 17, 1983Date of Patent: December 18, 1984Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Michael Boberg, Karl G. Metzger, Hans-Joachim Zeiler
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Patent number: 4405714Abstract: A process has been developed for the preparation of compounds of the formula ##STR1## wherein R is hydrogen or an optionally substituted alkyl radical, which comprises reacting glucose with a compound of the formula H.sub.2 N-R wherein R has the meaning given above to form a 1-amino-sorbitol of the formula ##STR2## wherein R has the meaning given above,reacting said 1-aminosorbitol with a compound providing a protective group which can be split off under acid conditions and is stable in the subsequent microbiological oxidation process, aerobically oxidizing the compound thus obtained microbiologically to give a protected 6-aminosorbose, splitting off the protective group under acid conditions and hydrogenating the 6-aminosorbose salt thus obtained either after being isolated or in one operation, to give the compound of the formula (I). The products obtained by the process of the invention are useful as .alpha.-glucoside inhibitors.Type: GrantFiled: September 25, 1981Date of Patent: September 20, 1983Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Michael Schedel, Wolfgang Koebernick
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Patent number: 4348402Abstract: The invention relates to .alpha.-hydroxyalkyl-3,4,5-trihydroxypiperidines defined by Formula (I), infra, and pharmaceutical compositions and medicaments containing said compounds. Also included in the invention are methods for the use of said compounds, compositions and medicaments as inhibitors of .alpha.-glucoside hydrolases; and intermediates for the compounds of said Formula (I).Type: GrantFiled: October 2, 1980Date of Patent: September 7, 1982Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Lutz Muller, Rudiger Sitt, Walter Puls
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Patent number: 4293551Abstract: The invention relates to N-amino-3,4,5-trihydroxypiperidines, methods for their production, compositions containing said compounds. Also included are methods for the use of said compounds and compositions.Type: GrantFiled: July 17, 1979Date of Patent: October 6, 1981Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Lutz Muller, Walter Puls, Rudiger Sitt
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Patent number: 4266025Abstract: The invention relates to a process for the production of compounds of the formula ##STR1## in which R is hydrogen or optionally substituted alkyl, alkenyl, aralkyl or aryl, by microbiological transformation of ##STR2## follow by catalytic hydrogenation. The compounds obtained are useful for the treatment of diabetes, hyperlipoproteinaemia and adiposity which comprises aerobically cultivates, in the presence of an assimilable source of carbon nitrogen, at a temperature of 20.degree. to 45.degree. C. and pH between 2 and 10 and in the presence of an effective amount of a compound of the formula ##STR3## in which R has the above-given meaning and,R.sub.1 denotes an optionally substituted benzyl radical or an optionally substituted .beta.-alkenyl group,an aerobic microorganism or an extract of aerobic microorganism capable, in a nutrient medium containing a compound of the formula (X), or accumulating an amount of a compound of the formula ##STR4## in which R and R.sub.Type: GrantFiled: November 23, 1979Date of Patent: May 5, 1981Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Michael Schedel
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Patent number: 4246345Abstract: The invention relates to a process for the production of 6-amino-6-deoxy-L-sorbose which comprises culturing an aerobic micro-organism capable of oxidizing 1-amino-1-deoxy-D-glucitol or an enzymatic extract obtained from said aerobic micro-organism under aerobic conditions and at a suitable temperature in an aqueous nutrient medium containing 1-amino-1-deoxy-D-glucitol or a salt thereof and also containing assimilable sources of carbon, nitrogen and essential trace element to impart said 6-amino-6-deoxy-L-sorbose to said aqueous nutrient medium.Type: GrantFiled: July 11, 1979Date of Patent: January 20, 1981Assignee: Bayer AktiengesellschaftInventors: Gunther Kinast, Michael Schedel