Abstract: A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer comprising a rotating disc having a feed-receiving surface driven from above by a hollow drive shaft, wherein axes of rotation of the hollow drive shaft and rotatable disc are coaxial and a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, the distributor and the well together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface.

Abstract: An apparatus for dosing solid particulate material into one or more receptacles, the apparatus comprising: a reservoir for containing an amount of solid particulate material; a dosing unit comprising a dose collection position for collecting a predetermined dose of solid particulate material from the reservoir, and a dose release position for releasing the solid particulate material into the one or more receptacles; a receptacle handling unit for retaining the one or more receptacles, arranged to at least periodically align at least one of the one or more receptacles with the dosing unit when in the dose release position; and optionally a receptacle closing unit for closing the one or more receptacles once filled with the solid particulate material; wherein the dosing unit comprises one or more dosing chambers arranged to displace relative to said reservoir, and/or vice versa, along a perpendicular axis Y such that at least a portion of the chamber(s) is capable of being immerged into, and emerged out of, the

Abstract: An apparatus for aseptic sealing a capsule having coaxial parts that at least partly overlap when telescopically joined, certain embodiments of the apparatus comprising: a capsule carrier assembly provided with at least one cavity for accommodating a respective capsule therein; a clamping member comprising a first half and a second half disposed on either side of the cavity at a capsule processing station, and each half arranged to linearly displace towards the cavity containing the capsule to a clamped position over and/or around at least a portion of the capsule; wherein the clamping member comprises a sealing means adapted to apply a sealing fluid uniformly to a circumferential gap around the capsule to be sealed when in the clamped position, and wherein the clamping member further comprises a suction means adapted to provide an area of low pressure around the capsule after application of the sealing fluid so as to remove any excess sealing fluid from the capsule when in the same clamped position.

Abstract: An apparatus for aseptic sealing a capsule having coaxial parts that at least partly overlap when telescopically joined, certain embodiments of the apparatus comprising: a capsule carrier assembly provided with at least one cavity for accommodating a respective capsule therein; a clamping member comprising a first half and a second half disposed on either side of the cavity at a capsule processing station, and each half arranged to linearly displace towards the cavity containing the capsule to a clamped position over and/or around at least a portion of the capsule; wherein the clamping member comprises a sealing means adapted to apply a sealing fluid uniformly to a circumferential gap around the capsule to be sealed when in the clamped position, and wherein the clamping member further comprises a suction means adapted to provide an area of low pressure around the capsule after application of the sealing fluid so as to remove any excess sealing fluid from the capsule when in the same clamped position.

Abstract: An apparatus for dosing solid particulate material into one or more receptacles, the apparatus comprising: a reservoir for containing an amount of solid particulate material; a dosing unit comprising a dose collection position for collecting a predetermined dose of solid particulate material from the reservoir, and a dose release position for releasing the solid particulate material into the one or more receptacles; a receptacle handling unit for retaining the one or more receptacles, arranged to at least periodically align at least one of the one or more receptacles with the dosing unit when in the dose release position; and optionally a receptacle closing unit for closing the one or more receptacles once filled with the solid particulate material; wherein the dosing unit comprises one or more dosing chambers arranged to displace relative to said reservoir, and/or vice versa, along a perpendicular axis Y such that at least a portion of the chamber(s) is capable of being immerged into, and emerged out of, the

Abstract: The present invention relates to a method and apparatus for sealing telescopically joined hard shell capsules. The method includes i. placing the capsule in a static sealing position in a capsule carrier assembly; ii. in the sealing position, applying a sealing fluid uniformly to the gap of the capsule; iii. rotating the capsule into a static suction position angularly spaced from the sealing position; and iv. in the suction position, providing an area of low pressure around the capsule so as to remove excess sealing liquid from the capsule. The apparatus includes a frame, a capsule carrier, a sealing device, and a suction device. The capsule carrier including a cavity configured to accommodate a capsule. The sealing device being configured apply a sealing fluid. The suction device being configured to provide an area of low pressure around a capsule in a cavity of the capsule carrier.

Abstract: A liquid pump for dispensing a liquid is provided. The pump comprises a body which defines a plurality of cylinders therein, each cylinder having located therein a respective piston, wherein each cylinder and respective piston is shaped and configured such that the fit between them substantially prevents leakage of the liquid to be dispensed. Such a liquid pump may be used to fill pharmaceutical dosage forms, such as capsules, with liquid pharmaceutical compositions.

Abstract: The present invention relates to a method and apparatus for sealing telescopically joined hardshell capsules. The method comprises i. placing the capsule (15) in a static sealing position (52) in a capsule carrier assembly (3); ii. in said sealing position (52), applying a sealing fluid uniformly to the gap of the capsule; iii. rotating the capsule (15) into a static suction position (53) angularly spaced from the sealing position (52); and iv. in said suction position (53), providing an area of low pressure around the capsule (15) so as to remove excess sealing liquid from the capsule.