Abstract: The invention provides methods for treating and diagnosing prostate cancer, as well as related positions and kits.

Abstract: The invention provides methods for treating and diagnosing prostate cancer, as well as related positions and kits.

Abstract: Aspects of the technology disclosed herein generally (and in part) relates to use of Angiogenin (ANG) for increasing hematopoietic reconstitution of in vivo hematopoietic cells and transplanted hematopoietic cells. Provided herein are methods and compositions useful in treatment of diseases characterized by decreased levels of hematopoietic cells, decreased levels of hematopoietic reconstitution, blood cell deficiency and prevention and treatment of radiation injury. One aspect relates to angiogenin treated hematopoietic cell compositions and methods of their use in stem cell transplantation. Treatment of hematopoietic cells with angiogenin enhances quiescence and reduces proliferative capacity of primitive hematopoietic stem cells while increasing proliferation of myeloid restricted progenitor cells. Another aspect relates to use of ANG in prophylactic and therapeutic treatment methods for radiation injury.

Abstract: Methods and compositions for treating neurodegenerative disorders using angiogenin and/or angiogenin variants are provided.

Abstract: A digital image capture device includes an image capture unit, a display unit, a selection unit, and a processing unit. The image capture unit is configured to capture an image. The display unit is configured to display the captured image and allow determination of a portion thereof to be selected. The selection unit is configured to allow selection of a portion of the image in response to user input based on the determination. The processing unit is configured to process the unselected portion of the image.

Abstract: Methods and compositions for treating neurodegenerative disorders are provided. Transgenic animal models of neurodegenerative disorders are provided. Knockout animal models of neurodegenerative disorders are also provided. Mutant angiogenin polypeptides are also provided.

Abstract: A digital image capture device includes an image capture unit, a display unit, a selection unit, and a processing unit. The image capture unit is configured to capture an image. The display unit is configured to display the captured image and allow determination of a portion thereof to be selected. The selection unit is configured to allow selection of a portion of the image in response to user input based on the determination. The processing unit is configured to process the unselected portion of the image.

Abstract: The present invention is directed to using neomycin or an analogue thereof as an therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells. The present invention is also directed to pharmaceutical compositions comprising (a) neomycin or an analogue and, optionally, (b) another anti-angiogenic agent or an anti-neoplastic agent. The present invention is further directed to a method for screening neomycin analogues having anti-angiogenic activity. A preferred embodiment of the invention relates to using neomycin to treat subjects having such diseases.