Patents by Inventor Guo J. Ye

Guo J. Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting of herpes simplex virus to specific receptors
    Patent number: 7501126
    Abstract: The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention may be used for targeting cells that express the selected receptor. The ability to selectively target cells renders the HSV particles particularly useful in selectively killing the selected receptor-bearing cells (such as tumor cells), imaging cells bearing the selected receptor, and providing gene replacement therapy to cells bearing the selected receptor.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: March 10, 2009
    Assignee: The University of Chicago
    Inventors: Bernard Roizman, Gouying Zhou, Guo J. Ye