Publication number: 20240368140
Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
Type:
Application
Filed:
February 20, 2024
Publication date:
November 7, 2024
Applicant:
EISAI R&D MANAGEMENT CO., LTD.
Inventors:
Gregg F. KEANEY, John WANG, Baudouin GERARD, Kenzo ARAI, Xiang LIU, Guo Zhu ZHENG, Kazunobu KIRA, Lisa A. MARCAURELLE, Marta NEVALAINEN, Ming-Hong HAO, Morgan Welzel O'SHEA, Parcharee TIVITMAHAISOON, Sudeep PRAJAPATI, Tuoping LUO, Nicholas C. GEARHART, Jason T. LOWE, Yoshihiko KOTAKE, Satoshi NAGAO, Regina Mikie KANADA SONOBE, Masayuki MIYANO, Norio MURAI, Andrew COOK, Shelby ELLERY, Atsushi ENDO, James PALACINO, Dominic REYNOLDS
Publication number: 20240310352
Abstract: The present disclosure relates to a method for analyzing a geological body with the help of physical and chemical properties thereof, and in particular, to a method for identifying an exudative sandstone uranium deposit. With the method for identifying an exudative sandstone uranium deposit according to the embodiments of the present disclosure, an exudative sandstone uranium deposit formed by an exudation metallogenesis may be systematically identified, so as to guide prediction and prospecting evaluation of a uranium deposit in red variegated sandstone formations of a sedimentary basin, avoid ore dislocation and ore leakage, open up new prospecting positions and spaces, and break through new uranium resources.
Type:
Application
Filed:
July 21, 2023
Publication date:
September 19, 2024
Inventors:
Ziying Li, Wusheng Liu, Mingkuan Qin, Yuqi Cai, Qingyin Guo, Feng He, Jun Zhong, Xide Li, Ye Sun, Yunlong Zhang, Weitao Li, Guo Wang, Shengfu Li, Jianfang Cai, Gui Wang, Shan Jiang, Jielin Zhang, Sheng He, Qubo Wu, Zilong Zhang, Chiheng Liu, Linfei Qiu, Hu Liu, Hongwei Ji, Qiang Guo, Pengfei Zhu, Xinyang Liu, Yuyan Zhang, Zhixin Huang, Jian Guo, Meizhi Han, Zhongbo He, Jinrong Lin, Licheng Jia, Junxian Wang, Longsheng Yi, Mingming Tian, Xiaoneng Luo, Bo Peng, Xiaoqian Xiu, Ruixiang Hao, Wenquan Wang, Changfa Yu