Patents by Inventor Guoqing Liu
Guoqing Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12295269Abstract: A low-cost and high-strength Bi-based superconducting wire/tape and a preparation method thereof, the preparation method includes: 1. subjecting a first Bi-based superconducting wire/tape to electrochemical silver reduction to remove a Ag alloy layer to obtain a second Bi-based superconducting wire/tape; and 2. subjecting the second Bi-based superconducting wire/tape to surface enhancement, such that a Cu layer is formed to obtain the low-cost and high-strength Bi-based superconducting wire/tape. An electrochemical silver reduction technology combines with an electrochemical additive method to remove a Ag alloy layer on a surface of a Bi-based superconducting wire/tape and coat a high-strength Cu layer, such that a low-cost and high-strength Bi-based superconducting wire/tape can be prepared, which reduces a preparation cost and improves a strength of a Bi-based superconducting wire/tape to meet the application requirements of large super-strong magnets.Type: GrantFiled: May 3, 2024Date of Patent: May 6, 2025Assignee: NORTHWEST INSTITUTE FOR NONFERROUS METAL RESEARCHInventors: Qingbin Hao, Jianfeng Li, Shengnan Zhang, Lihua Jin, Xiaoyan Xu, Gaofeng Jiao, Kai Yao, Chengshan Li, Guoqing Liu, Zhenbao Li, Xueqian Liu, Gaoshan Li, Jianqing Feng, Pingxiang Zhang
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Publication number: 20250093549Abstract: A method for quantifying a structural feature forecast error of a meteorological element based on a graphical similarity is based on the concept of graphical similarity to propose a normalized evaluation technique for a forecast error of a scalar meteorological element such as rainfall, radar reflectivity, temperature, visibility, or wind speed. The method can objectively and truly reflect the true capability of forecasting the meteorological element such as precipitation.Type: ApplicationFiled: April 21, 2024Publication date: March 20, 2025Applicant: Nanjing Joint Institute for Atmospheric SciencesInventors: Xiyu MU, Guoqing LIU, Hao CHENG, Qi XU, Mingjian ZENG, Kan DAI, Hao YAN, Shuqi YAN, Huadong YANG, Hao WU, Yan ZENG
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Publication number: 20250082763Abstract: A combination drug for treating triple-negative breast cancer. Androgen receptor-targeting degraders (including PROTACs) can effectively prevent and/or treat triple negative breast cancer (including androgen receptor-positive triple negative breast cancer). The combined use of an androgen receptor degrader and a targeting drug (including PI3K? inhibitors and PARP inhibitors), immunotherapy drug or chemotherapy drug can effectively prevent and/or treat triple negative breast cancer.Type: ApplicationFiled: November 18, 2024Publication date: March 13, 2025Inventors: Jing LI, Wu DU, Guoqing LIU, Yongxu HUO, Kefan CHEN, Xinghai LI
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Publication number: 20250082764Abstract: Provided is a drug for treating triple negative breast cancer. Provided is use of an androgen receptor (AR) degrader (including PROTAC) in the preparation of a drug for preventing and/or treating triple negative breast cancer (including androgen receptor positive triple negative breast cancer). Provided is use of an AR degrader in combination with a targeting drug (comprising a PI3K? inhibitor and a PARP inhibitor), an immunotherapy drug or a chemotherapeutic drug in the preparation of a drug for preventing and/or treating triple negative breast cancer.Type: ApplicationFiled: November 18, 2024Publication date: March 13, 2025Inventors: Jing LI, Wu DU, Guoqing LIU, Yongxu HUO, Kefan CHEN, Xinghai LI
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Publication number: 20250059225Abstract: The present disclosure provides a method for preparing stachyose, which method belongs to the technical field of the production of carbohydrates. The method includes: breaking the wall of Stachys affinis; subjecting the resulting wall-broken material to filter pressing to obtain a filtrate and filter residues; decoloring the filtrate to obtain a decolored liquid; filtering the decolored liquid with a nanofiltration membrane to obtain a nanofiltration liquid; subjecting the nanofiltration liquid to a mixed bed ion exchange treatment to obtain an exchanged liquid; purifying the exchanged liquid by means of continuous simulated moving bed chromatography to obtain a purified liquid; and concentrating and vacuum drying the purified liquid to obtain stachyose.Type: ApplicationFiled: December 27, 2022Publication date: February 20, 2025Applicant: SHANDONG BAILONG CHUANGYUAN BIO-TECH CO., LTDInventors: Qian DU, Lingling CHEN, Jianjin Dong, Xianbao SHAO, Guoqing LIU
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Publication number: 20240389474Abstract: A low-cost and high-strength Bi-based superconducting wire/tape and a preparation method thereof, the preparation method includes: 1. subjecting a first Bi-based superconducting wire/tape to electrochemical silver reduction to remove a Ag alloy layer to obtain a second Bi-based superconducting wire/tape; and 2. subjecting the second Bi-based superconducting wire/tape to surface enhancement, such that a Cu layer is formed to obtain the low-cost and high-strength Bi-based superconducting wire/tape. An electrochemical silver reduction technology combines with an electrochemical additive method to remove a Ag alloy layer on a surface of a Bi-based superconducting wire/tape and coat a high-strength Cu layer, such that a low-cost and high-strength Bi-based superconducting wire/tape can be prepared, which reduces a preparation cost and improves a strength of a Bi-based superconducting wire/tape to meet the application requirements of large super-strong magnets.Type: ApplicationFiled: May 3, 2024Publication date: November 21, 2024Applicant: NORTHWEST INSTITUTE FOR NONFERROUS METAL RESEARCHInventors: Qingbin HAO, Jianfeng LI, Shengnan ZHANG, Lihua JIN, Xiaoyan XU, Gaofeng JIAO, Kai YAO, Chengshan LI, Guoqing LIU, Zhenbao LI, Xueqian LIU, Gaoshan LI, Jianqing FENG, Pingxiang ZHANG
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Publication number: 20230418433Abstract: A computing system for pixel-based automated testing of a navigable simulated environment includes one or more processors configured to execute, in a run-time inference phase, an application testing program. The application testing program includes a machine learning model trained to detect errors in the application under test. A screen image of the simulated environment is processed by an object detection module to determine if a key object is present in the screen image. If a key object is present in the screen image, the application testing program executes an object investigation module to generate investigation inputs to investigate the key object. If a key object is not present in the screen image, the application testing program executes an environment exploration module to generate an environment exploration action to be provided to the application under test as simulated user input.Type: ApplicationFiled: July 17, 2023Publication date: December 28, 2023Applicant: Microsoft Technology Licensing, LLCInventors: Guoqing LIU, Li ZHAO, Tao QIN, Adrian Lee BROWN, James Eugene BISCHOFF, JR., Tieyan LIU
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Publication number: 20230349849Abstract: Transient techniques for electrothermal characterization of small (e.g., micro-scale or nano-scale) samples are described. These techniques overcome some of the limitations existing in conventional approaches. These transient techniques involve causing a temperature variation inside a sample, and determining a transient signal response (e.g., a voltage rise or drop) arising in the sample as a result of the temperature variation. In some embodiments, the temperature variation may be caused by allowing amplitude modulated electric current (e.g., stepped current or periodic stepped current) to flow through the sample. Alternatively, or additionally, the temperature variation may be caused by controlling a laser source to irradiate the sample. Thermal characteristics of the sample (e.g., thermal diffusivity, thermal conductivity, specific heat) can be determined based on the transient response. These transient techniques can be executed by a computer system in an automatic fashion, e.g.Type: ApplicationFiled: August 25, 2022Publication date: November 2, 2023Applicant: ACS Thermal LLCInventors: Guoqing Liu, Richard S. Ploss, Xinwei Wang
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Publication number: 20230328422Abstract: A headset includes a first through hole and a second through hole disposed in a housing. In this configuration, when the headset is worn on a left ear, the first through hole communicates with an auditory canal, the second through hole is partially or completely shielded by the ear, and the first through hole can propagate sound to the left ear, when the headset is worn on a right ear, the second through hole communicates with an auditory canal, the first through hole is partially or completely shielded by the ear, and the second through hole can propagate sound to the auditory canal.Type: ApplicationFiled: August 10, 2021Publication date: October 12, 2023Inventor: Guoqing Liu
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Patent number: 11669579Abstract: Disclosed are a method and apparatus for providing search results. The method may include: carrying out search intention analysis on an input search term so as to determine whether the search term includes an answer requirement; if so, using the search term to retrieve answer content corresponding to the answer requirement; obtaining content to be recommended associated with the answer content; and combining the answer content with the content to be recommended so as to generate at least one search result. Abundant search results can be efficiently provided.Type: GrantFiled: August 14, 2019Date of Patent: June 6, 2023Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.Inventors: Guoqing Liu, Yinfang Jia, Yanfeng Zhu, Cong Han, You Han, Peng Li, Yueran Dang, Min Chen
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Publication number: 20230101933Abstract: This application discloses a method and apparatus for generating virtual equipment, a storage medium, and an electronic device. The method includes displaying identifiers of virtual equipment in a target game interface, the virtual equipment comprising first virtual equipment and second virtual equipment; receiving a first triggering operation performed on the identifier of the first virtual equipment from the target game interface; in response to the first triggering operation, displaying a candidate identifier of a first fused virtual equipment, the first fused virtual equipment is a fusion of the second virtual equipment and the first virtual equipment in the target game interface; and in response to dragging the identifier of the first virtual equipment and dropping the identifier at a position overlapped with an identifier of the second virtual equipment, fusing the second virtual equipment and the first virtual equipment.Type: ApplicationFiled: December 1, 2022Publication date: March 30, 2023Inventors: Lin LIN, Guoqing LIU
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Patent number: 11252245Abstract: Embodiments can include an information pushing method and device. An embodiment of the method can include: receiving an information stream data acquisition request sent by a terminal, wherein the information stream data acquisition request comprises query information; performing a query according to the query information to obtain first information stream data; acquiring at least one of a search record or a browsing record of an account associated with the terminal with respect to a predetermined time period; determining, based on the at least one of the search record or the browsing record, a keyword; determining second information stream data located in a preset information stream data set and matching the key word; generating, based on the first information stream data and the determined second information stream data, data to be pushed; and pushing to the terminal the data to be pushed. The embodiment can achieve targeted information pushing.Type: GrantFiled: July 11, 2019Date of Patent: February 15, 2022Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.Inventors: Xuyong Shi, Cong Han, Dengwu He, Luguang Wang, Xiufei Wang, Renpeng Liang, Jiajun Yang, Guoqing Liu, Cheng Yang, Zhimin Jiang
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Publication number: 20210239030Abstract: The present application provides an engine cooling system, which includes: a coolant pump; a cylinder body (22) and a cylinder cover (24), which include inside coolant passages for receiving coolant from the coolant pump, conduct heat exchange through a coolant outlet of the cylinder head (24), and send parts of the coolant back to the coolant pump; a transmission oil cooler (60) for receiving parts of the coolant from the cylinder head (24), and allowing the parts of the coolant to flow back to the coolant pump after heat exchange; the cylinder head (24) includes an upper water jacket and a lower water jacket, a temperature of the coolant output by the upper water jacket of the cylinder head is higher than a temperature of the coolant output by the lower water jacket of the cylinder head.Type: ApplicationFiled: August 6, 2019Publication date: August 5, 2021Applicants: GUIZHOU GEELY ENGINE CO., LTD., ZHEJIANG GEELY HOLDING GROUP CO., LTDInventors: Yutao XU, Li HE, Shujie HUANG, Wei LIU, Xiaobo ZHAO, Qiang LI, Guoqing LIU, Mingyue WANG, Fucheng ZHAO, Ruiping WANG
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Patent number: 10932454Abstract: Provided is a method for preparing a genetically-engineered hamster comprising in vivo knocking out an LDL receptor gene in the hamster. The LDL receptor gene is knocked out by CRISPR/CAS9 gene editing technique. The genetically-engineered hamster shows significantly high levels of blood lipids, and it thus well-suited for direct use in hyperlipidemia and arteriosclerosis studies, and is a small animal model with high similarities to human familial hypercholesterolemia. Also provided is a method for screening drugs using the genetically-engineered hamster.Type: GrantFiled: February 1, 2017Date of Patent: March 2, 2021Assignee: HEBEI INVIVO BIOTECH INCInventor: Guoqing Liu
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Publication number: 20190370305Abstract: Disclosed are a method and apparatus for providing search results. The method may include: carrying out search intention analysis on an input search term so as to determine whether the search term includes an answer requirement; if so, using the search term to retrieve answer content corresponding to the answer requirement; obtaining content to be recommended associated with the answer content; and combining the answer content with the content to be recommended so as to generate at least one search result. Abundant search results can be efficiently provided.Type: ApplicationFiled: August 14, 2019Publication date: December 5, 2019Inventors: Guoqing LIU, Yinfang JIA, Yanfeng ZHU, Cong HAN, You HAN, Peng LI, Yueran DANG, Min CHEN
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Publication number: 20190335011Abstract: Embodiments can include an information pushing method and device. An embodiment of the method can include: receiving an information stream data acquisition request sent by a terminal, wherein the information stream data acquisition request comprises query information; performing a query according to the query information to obtain first information stream data; acquiring at least one of a search record or a browsing record of an account associated with the terminal with respect to a predetermined time period; determining, based on the at least one of the search record or the browsing record, a keyword; determining second information stream data located in a preset information stream data set and matching the key word; generating, based on the first information stream data and the determined second information stream data, data to be pushed; and pushing to the terminal the data to be pushed. The embodiment can achieve targeted information pushing.Type: ApplicationFiled: July 11, 2019Publication date: October 31, 2019Inventors: Xuyong SHI, Cong HAN, Dengwu HE, Luguang WANG, Xiufei WANG, Renpeng LIANG, Jiajun YANG, Guoqing LIU, Cheng YANG, Zhimin JIANG
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Patent number: 10294466Abstract: The present disclosure relates to polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia or engineered polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia homologs. The present disclosure also pertains to polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, host cells and mutant cells comprising the polynucleotides. The disclosure further pertains to compositions comprising such polypeptides, methods of producing the polypeptides and compositions, as well as methods for using such polypeptides and compositions for industrial applications.Type: GrantFiled: February 25, 2016Date of Patent: May 21, 2019Assignee: DANISCO US INC.Inventors: Zheyong Yu, Zhenghong Zhang, Jing Ge, Zhen Qian, Guoqing Liu, Zhiyong Xie, Zhongmei Tang
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Publication number: 20190037817Abstract: Provided is a method for preparing a genetically-engineered hamster comprising in vivo knocking out an LDL receptor gene in the hamster. The LDL receptor gene is knocked out by CRISPR/CAS9 gene editing technique. The genetically-engineered hamster shows significantly high levels of blood lipids, and it thus well-suited for direct use in hyperlipidemia and arteriosclerosis studies, and is a small animal model with high similarities to human familial hypercholesterolemia. Also provided is a method for screening drugs using the genetically-engineered hamster.Type: ApplicationFiled: February 1, 2017Publication date: February 7, 2019Applicant: HEBEI INVIVO BIOTECH INCInventor: Guoqing LIU
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Publication number: 20180016563Abstract: The present disclosure relates to polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia or engineered polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia homologs. The present disclosure also pertains to polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, host cells and mutant cells comprising the polynucleotides. The disclosure further pertains to compositions comprising such polypeptides, methods of producing the polypeptides and compositions, as well as methods for using such polypeptides and compositions for industrial applications.Type: ApplicationFiled: February 25, 2016Publication date: January 18, 2018Applicant: DANISCO US INC.Inventors: Zheyong YU, Zhenghong ZHANG, Jing GE, Zhen QIAN, Guoqing LIU, Zhiyong XIE, Zhongmei TANG
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Publication number: 20160318454Abstract: Disclosed are driving recording device and regulation and control method using the same. The device includes a driving recorder and a regulating member. The recorder includes a processor, a gyroscope and an acceleration sensor. The processor sends control instruction to regulating member according to received three-dimensional angular information from gyroscope and three-dimensional acceleration information from acceleration sensor, to control it to perform position regulation and to lead position regulation of recorder such that recorder is in initial status and balanced. The gyroscope, the acceleration sensor and the regulating member are in communication connection with the processor, respectively, and the recorder is connected to regulating member and connected to a vehicle thereby.Type: ApplicationFiled: December 4, 2015Publication date: November 3, 2016Inventor: Guoqing LIU