Abstract: The present teaching relates to surgical procedure assistance. In one example, a first image of an organ having a lesion is obtained prior to a surgical procedure. Information related to a pose of a surgical instrument at a first location with respect to the lesion is received from a sensor coupled with the surgical instrument. A visual environment having the lesion and the surgical instrument rendered therein is generated based on the first image and the information received from the sensor. A second image of the organ is obtained when the surgical instrument is moved to a second location with respect to the lesion during the surgical procedure. The second image captures the lesion and the surgical instrument. The pose of the surgical instrument and the lesion rendered in the visual environment are adjusted based, at least in part, on the second image.

Abstract: The present teaching relates to surgical procedure assistance. In one example, a first set of positions of a plurality of sensors are obtained in an image captured prior to a surgical procedure. The plurality of sensors are coupled with a patient's body. One or more second sets of positions of the plurality of sensors are obtained based on information from a tracking device associated with the plurality of sensors. The one or more second sets of positions change in accordance with movement of the patient's body. One or more similarity measures are calculated between the first set of positions and each of the one or more second sets of positions of the plurality of sensors. A timing at which the surgical procedure initiates is determined based on the one or more similarity measures.

Abstract: A workflow to optimize a fracturing fluid for injection into a subterranean formation is provided. The workflow comprises measurement of fundamental properties and characteristics of reservoir rock and fluid, their interaction with fracturing fluid, computer-based models and laboratory performance testing to select preferred fracturing base fluid and additives package for use in fracturing/re-fracturing stimulation of specific shale formations to enhance hydrocarbon recovery.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: The present invention provides Ras modulators including inhibitors and/or antagonists of Ras, Ras binding, and Ras-dependent cell signaling activity. Also provided are methods of utilizing the Ras modulators as therapeutics.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: The present disclosure relates to a system and method of providing surgical assistance. The method includes obtaining a 3D space including an organ and a lesion located within the organ. Based on a shape of the organ, a grid is overlaid on a surface of the organ. The lesion is projected at a first location on an overlaid grid. A graphical tool disposed in a first orientation is positioned at the first location in the 3D space, and a plurality of parameter values of the lesion corresponding to the first orientation of the graphical tool are displayed in the 3D space. The graphical tool is manipulated to be disposed in a second orientation at a second location on the overlaid grid, and the plurality of parameter values of the lesion corresponding to the second orientation of the graphical tool are displayed in the 3D space.

Abstract: A workflow to optimize a fracturing fluid for injection into a subterranean formation is provided. The workflow comprises measurement of fundamental properties and characteristics of reservoir rock and fluid, their interaction with fracturing fluid, computer-based models and laboratory performance testing to select preferred fracturing base fluid and additives package for use in fracturing/re-fracturing stimulation of specific shale formations to enhance hydrocarbon recovery.

Abstract: The present teaching relates to method and system for aligning a virtual anatomic model. The method generates a virtual model of an organ of a patient, wherein the virtual model includes at least three virtual markers. A number of virtual spheres equal to a the number of virtual markers are generated, wherein the virtual spheres are disposed on the virtual model of the organ of the patient and associated with the virtual markers. A first position of the virtual spheres and the virtual markers is recorded. The virtual spheres are placed to coincide with physical markers disposed on the patient and a second position of the virtual spheres is recorded. A transformation of the virtual spheres and the virtual markers based on the first and second positions is computed and the virtual model of the organ is aligned with the patient based on the computed transformation.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: This invention provides polypeptides that were identified as interacting with Vip3 toxin. This invention also provides a method of identifying agents that bind to Vip3 interacting polypeptides, which agents may act as insecticidal agent, cytotoxic agents and/or modulate the activity of Vip3 interacting polypeptides.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: The present teaching relates to surgical procedure assistance. In one example, a plurality of similarity measures are determined between a first set of positions and a plurality of second sets of positions, respectively. The first set of positions is obtained with respect to a plurality of sensors coupled with a patient in an image captured prior to a surgical procedure. The plurality of second sets of positions are obtained from the plurality of sensors and change in accordance with movement of the patient. A target lesion is segmented in the image captured prior to the surgical procedure to obtain a lesion display object. The lesion display object is duplicated to generate a plurality of lesion display objects. The plurality of lesion display objects are presented on a display screen so that a distance between the plurality of lesion display objects changes in accordance with the plurality of the similarity measures.

Abstract: The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: A method for making a tri-gate FinFET and a dual-gate FinFET includes providing a semiconductor on insulator (SOI) wafer having a semiconductor layer over an insulator layer. The method further includes forming a hard mask on the semiconductor layer and patterning the hard mask to form first and second cap portions. The method also includes etching the semiconductor layer to form first and second fins using the first and second cap portions as an etch mask. The method also includes removing the second cap portion to expose the top surface of the second fin and forming a gate dielectric layer on the first and second fins. The method further includes forming a conductive layer over the gate dielectric layer, selectively etching the conductive layer to form first and second gate structures, forming an interlayer dielectric layer over the gate structures, and planarizing the interlayer dielectric layer using the first cap portion as a polish stop.

Abstract: The present teaching relates to surgical procedure assistance. In one example, a first volume of air inside a lung is obtained based on a first image of the lung captured prior to a surgical procedure. The lung has a first shape on the first image. A second volume of air deflated from the lung is determined based on a second image of the lung captured during the surgical procedure. A second shape of the lung is estimated based on the first shape of the lung and the first air volume inside the lung and second volume of air deflated from the lung. A surgical plan is updated based on the estimated second shape of the lung.

Abstract: A method for labeling vessel branches forming first and second vessel systems. A 3D image is segmented to obtain vessel branches. First and second root points are then determined. Starting from the first root point, the vessel branches are traced to derive a tracing path and a break point is determined, that separates the tracing path into two portions. A region of interest in the 3D image is determined with respect to the break point, in which center lines are assigned to the first or second vessel system. A 3D cutting structure is generated based on distances measured from points on the center lines to the 3D cutting structure. Graph representations are constructed for the first and second vessel systems. The vessel branches are labeled with different labels based on the graph representations.

Abstract: The present teaching relates to surgical procedure assistance. In one example, a first volume of air inside a lung is obtained based on a first image of the lung captured prior to a surgical procedure. The lung has a first shape on the first image. A second volume of air deflated from the lung is determined based on a second image of the lung captured during the surgical procedure. A second shape of the lung is estimated based on the first shape of the lung and the first air volume inside the lung and second volume of air deflated from the lung. A surgical plan is updated based on the estimated second shape of the lung.

Abstract: The present disclosure relates to a system and method of providing surgical assistance. The method includes obtaining a 3D space including an organ and a lesion located within the organ. Based on a shape of the organ, a grid is overlaid on a surface of the organ. The lesion is projected at a first location on an overlaid grid. A graphical tool disposed in a first orientation is positioned at the first location in the 3D space, and a plurality of parameter values of the lesion corresponding to the first orientation of the graphical tool are displayed in the 3D space. The graphical tool is manipulated to be disposed in a second orientation at a second location on the overlaid grid, and the plurality of parameter values of the lesion corresponding to the second orientation of the graphical tool are displayed in the 3D space.