Abstract: Provided are novel DNA constructs or RNA transcripts for making circular RNAs, as well as novel methods of producing circular RNAs.

Abstract: The present invention is applicable to the fields of panoramic images and videos, and provides a panoramic image and video splicing method, and a panoramic camera. In the present invention, fisheye photos captured by two adjacent cameras are mapped to corresponding seam areas of a sphere model, so as to form two strip graphs having overlapping areas; performing block template matching on the two strip graphs to obtain an initial template matching result; performing matching filtering on the initial template matching result by using an area expansion-based matching filtering algorithm, so as to obtain a final matching result; and updating a mapping relationship between the fisheye photos and the corresponding seam areas of the sphere model, and performing panoramic splicing according to the updated mapping relationship to obtain a seamless panoramic image.

Abstract: The fisheye image compression method comprises: acquiring positioning information of a render region of a decoding end; identifying a fisheye render region and a fisheye non-render region in fisheye image according to the positioning information, wherein and compressing the fisheye image to obtain a compressed image compression ratio of the fisheye render region in the compressed image is less than the compression ratio of the fisheye non-render region therein, and/or the fisheye render region is not compressed. By means of the method, the image transmission bandwidth can be saved by image compression; moreover, the compression ratio of a compressed fisheye render region is relatively small, or a fisheye render region is subjected to lossless compression, such that a finally rendered picture cannot be excessively compressed, thereby avoiding a reduction in the quality of the picture and ensuring the definition of a picture in a render region.

Abstract: The present disclosure relates to a method for analyzing a geological body with the help of physical and chemical properties thereof, and in particular, to a method for identifying an exudative sandstone uranium deposit. With the method for identifying an exudative sandstone uranium deposit according to the embodiments of the present disclosure, an exudative sandstone uranium deposit formed by an exudation metallogenesis may be systematically identified, so as to guide prediction and prospecting evaluation of a uranium deposit in red variegated sandstone formations of a sedimentary basin, avoid ore dislocation and ore leakage, open up new prospecting positions and spaces, and break through new uranium resources.

Abstract: Disclosed are a method for the synthesis of roxadustat and an intermediate thereof, and an intermediate thereof. In particular, disclosed is a method for the synthesis of compound M1, the method comprising the following steps: carrying out a reaction as shown below between compound SM and compound SM-A under the action of an oxidizing agent. The method of the present invention uses cheap and easily available raw materials, has short reaction steps, produces a high yield, has simple and convenient post-treatment procedures, and is suitable for industrial production.

Abstract: The present invention provides a method for testing and fitting the dihedral angle parameters in force field. The method first generates some representative conformations, and then compares the results of force field and quantum mechanics methods using these structures. If the results meet the predefined standards, the process ends; otherwise the molecule will be cut into small-size molecular fragments with only one flexible dihedral angle in each fragment. The dihedral angles will be scanned. And results of force field and quantum mechanics will be compared for each scanned flexible dihedral angle to find out those that do not meet the standards, and their parameters will be selected for further fitting. After new dihedral angle parameters are obtained, apply them to the original series of conformers of the whole molecule for validation. If results meet the standards, complete the whole process of testing and fitting poorly performing dihedral angle parameters.

Abstract: The present invention is applicable to the fields of panoramic images and videos, and provides a panoramic image and video splicing method, and a panoramic camera. In the present invention, fisheye photos captured by two adjacent cameras are mapped to corresponding seam areas of a sphere model, so as to form two strip graphs having overlapping areas; performing block template matching on the two strip graphs to obtain an initial template matching result; performing matching filtering on the initial template matching result by using an area expansion-based matching filtering algorithm, so as to obtain a final matching result; and updating a mapping relationship between the fisheye photos and the corresponding seam areas of the sphere model, and performing panoramic splicing according to the updated mapping relationship to obtain a seamless panoramic image.

Abstract: Described herein are methods and compositions related to the treatment or prevention of an inflammatory disease via administration of an agent that inhibits a long noncoding RNA (Inc-RNA) expressed in a macrophage to a subject in need thereof. In one embodiment, the Inc-RNA is lnc-FAM164A1. Another aspect herein provides a method of treating or preventing an inflammatory disease via administration of an agent that inhibits a protein bound to a Inc-RNA, e.g., ACLY, to a subject in need thereof.

Abstract: A method for web application layer attack detection and defense based on behavior characteristic matching and analysis includes presetting a defense rule base, the defense rule base including a plurality of defense rules; acquiring a record that access request data matches the defense rule base in a web application protection system and taking the record as sample data; learning the sample data to establish an analysis model; establishing a user reputation database and setting a blacklist module in the user reputation database; learning the user's access behavior through the analysis model and updating and correcting the defense rules in the defense rule base; establishing an exception defense rule base; and setting a defense method and intercepting the user's access behavior according to the defense method. By intelligently learning the user's behavior, threat behavior can be identified and intercepted quickly to ensure the security of the web server.

Abstract: A diagnostic assistance method is provided in the invention. The diagnostic assistance method includes the steps of generating audio data with a stethoscope; generating image data via an ultrasonic device; processing the audio data through a first processing module to generate a first result; processing the image data through a second processing module to generate a second result; and generating a diagnostic assistance result according to the first result and the second result.

Abstract: An ultrasonic-based pulse-taking device and a pulse-taking method thereof which are adapted to detect a pulse condition of a person are provided. The pulse-taking method includes: sensing a blood vessel of the person to generate a color Doppler image and a blood flow waveform image. Determining the pulse condition based on the color Doppler image and the blood flow waveform image.

Abstract: Data input supporting method and apparatus are disclosed. The data input supporting method includes receiving virtual data sent by an intelligent mobile device, analyzing the received virtual data according to a pre-stored key value mapping file, the key value mapping file saving a mapping relationship between the virtual data and a real instruction, encapsulating the real instruction obtained by analyzing the virtual data, and sending the encapsulated real instruction to a pre-established virtual device node, filling the real instruction into a corresponding system function by the virtual device node automatically according to an instruction type; and responding to a kernel space data injection event generated by filling the real instruction into the system function. Embodiments of the invention can support non-contact control of the intelligent mobile device to an electronic product through a wireless connection, thereby providing desirable user experience.

Abstract: A method for web application layer attack detection and defense based on behavior characteristic matching and analysis includes presetting a defense rule base, the defense rule base including a plurality of defense rules; acquiring a record that access request data matches the defense rule base in a web application protection system and taking the record as sample data; learning the sample data to establish an analysis model; establishing a user reputation database and setting a blacklist module in the user reputation database; learning the user's access behavior through the analysis model and updating and correcting the defense rules in the defense rule base; establishing an exception defense rule base; and setting a defense method and intercepting the user's access behavior according to the defense method. By intelligently learning the user's behavior, threat behavior can be identified and intercepted quickly to ensure the security of the web server.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Abstract: Embodiments of the present application are directed to an automation process method to generate a set of wetland predictive variables using Light Detection and Ranging (“LiDAR”) data within a geographic information system (“GIS”) software platform, according to some embodiments, and to model and predict wetland in ArcGIS platform using the generated variable set. The automatic process also can run analysis on and display of the predicted wetland. The process is built by developing modules and connection in GIS. The above mentioned processes are automatically run and may just be run by one-button press, or on click, or separate buttons press, or separate clicks.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.