Abstract: The present invention relates to methods of preparing substituted indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, and intermediate compounds useful for preparing said compounds. These compounds are useful for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method is described for preparing metal ink for additive manufacturing based on photo-thermal synergistic curing, relating to functional ink technology. The ink includes 50%-95% metal powder, 1%-35% photosensitive resin, 1%-35% photosensitive monomer, 0.1%-7% photoinitiator, 0.1%-5% thermal initiator, 0.1%-5% up-conversion material, and 0%-2% auxiliary agent. The method includes adding metal ink to the ink tank of a direct ink writing 3D printer, extruding the metal ink from the nozzle under computer control to the printing specific shapes on the platform, and curing under real-time illumination of a specific light source to obtain the green body. The method includes performing high-temperature debinding treatment on the obtained green body in a specific atmosphere. The treated green body is subjected to a high-temperature and high-pressure sintering treatment in a specific atmosphere and then cooled to room temperature.

Abstract: A method is described for preparing metal ink for additive manufacturing based on photo-thermal synergistic curing, relating to functional ink technology. The ink includes 50%-95% metal powder, 1%-35% photosensitive resin, 1%-35% photosensitive monomer, 0.1%-7% photoinitiator, 0.1%-5% thermal initiator, 0.1%-5% up-conversion material, and 0%-2% auxiliary agent. The method includes adding metal ink to the ink tank of a direct ink writing 3D printer, extruding the metal ink from the nozzle under computer control to the printing specific shapes on the platform, and curing under real-time illumination of a specific light source to obtain the green body. The method includes performing high-temperature debinding treatment on the obtained green body in a specific atmosphere. The treated green body is subjected to a high-temperature and high-pressure sintering treatment in a specific atmosphere and then cooled to room temperature.

Abstract: The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method of forming solder paste on an object is provided. The method includes providing a multilayered stencil, each stencil layer having an aperture formed therethrough from a top surface of the respective stencil layer to a bottom surface of the stencil layer. The method also includes applying the stencil to a surface of the object. The method also includes filling a void space formed by a combination of the apertures in the stencil layers with solder paste. The method also includes removing the stencil layers in a sequential manner to leave the solder paste.

Abstract: The disclosure discloses a detection coil structure based on interlayer coupling and a metal object detection system. The detection coil structure includes: a top sub-detection coil and a bottom sub-detection coil, wherein the top and bottom sub-detection coils are the same in structure and similar or same in size and are orthogonal to each other, and both the outer boundaries and geometric symmetry centers of the detection coils are completely coincident; the top sub-detection coil includes a first terminal, a second terminal, a third terminal and a fourth terminal, and the bottom sub-detection coil includes a fifth terminal, a sixth terminal, a seventh terminal and an eighth terminal; and the first terminal is connected to the second terminal, the seventh terminal is connected to the eighth terminal, and the third terminal and the fourth terminal are respectively connected to the fifth terminal and the sixth terminal.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure provides a method for recovering a porosity evolution process of sequence stratigraphy of carbonate rocks. The method comprises: a step of establishing a sequence stratigraphic framework of carbonate rocks; a step of dividing diagenetic stages; a step of simulating diagenesis and porosity evolution with increasing reservoir thickness and continuous superposition of multiple reservoirs during cyclic rise and fall of sea level to obtain a simulation result; and a step of calculating the porosity evolution in space over time by using the simulation result as initial values for simulation of diagenetic evolution process and simulating in stages and continuity the multi-stage diagenetic evolution process that the carbonate rock strata undergo after sediment based on the divided diagenetic stages.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The disclosure discloses a detection coil structure based on interlayer coupling and a metal object detection system. The detection coil structure includes: a top sub-detection coil and a bottom sub-detection coil, wherein the top and bottom sub-detection coils are the same in structure and similar or same in size and are orthogonal to each other, and both the outer boundaries and geometric symmetry centers of the detection coils are completely coincident; the top sub-detection coil includes a first terminal, a second terminal, a third terminal and a fourth terminal, and the bottom sub-detection coil includes a fifth terminal, a sixth terminal, a seventh terminal and an eighth terminal; and the first terminal is connected to the second terminal, the seventh terminal is connected to the eighth terminal, and the third terminal and the fourth terminal are respectively connected to the fifth terminal and the sixth terminal.

Abstract: The present disclosure provides a method for recovering a porosity evolution process of sequence stratigraphy of carbonate rocks. The method comprises: a step of establishing a sequence stratigraphic framework of carbonate rocks; a step of dividing diagenetic stages; a step of simulating diagenesis and porosity evolution with increasing reservoir thickness and continuous superposition of multiple reservoirs during cyclic rise and fall of sea level to obtain a simulation result; and a step of calculating the porosity evolution in space over time by using the simulation result as initial values for simulation of diagenetic evolution process and simulating in stages and continuity the multi-stage diagenetic evolution process that the carbonate rock strata undergo after sediment based on the divided diagenetic stages.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to methods of preparing substituted indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, and intermediate compounds useful for preparing said compounds. These compounds are useful for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.