Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: A method for adjusting audio frequency includes steps of: obtaining initial frequency and temporary data storage of audio data input to a buffering unit; performing a first adjustment procedure on initial frequency to obtain a first variation of temporary data storage corresponding to a first change of initial frequency; calculating a first frequency correction amount according to first variation and a first period of first adjustment procedure; adjusting initial frequency into first frequency according to first frequency correction amount; inputting first frequency into buffering unit; performing a second adjustment procedure on first frequency to obtain a second variation of temporary data storage corresponding to a second change of first frequency; calculating a second frequency correction amount according to second variation and a second period of second adjustment procedure, which first period is less than second period; and adjusting first frequency into target frequency according to second frequency co

Abstract: A test system includes a transmitter, capacitor, and receiver. The transmitter includes: an output circuit coupled to the receiver via the capacitor; a transmitting circuit transmitting a predetermined signal to a pad of the output circuit during a first test; a signal generator outputting a first signal and second signal to the pad during a first process and second process of a second test; and a comparator comparing the pad's signal with a reference signal in the first process and second process to determine whether the second test passes. The receiver includes: an input circuit coupled to the transmitter via the capacitor; a switch coupled between the input circuit and a receiving circuit to be conducting in the first test and second process and nonconducting in the first process; and the receiving circuit determining whether the first test passes according to the predetermined signal and assisting the capacitor in discharging.

Abstract: A control mechanism of a vehicle-mounted system for electromagnetic launch of fire extinguishing bombs for high-rise buildings is provided. A stress wave amplifier is fixedly connected to a secondary coil, a primary coil is fixedly connected to a coil base, a guide shaft passes through a central hole in the primary coil and the coil base, and a head of the guide shaft is fixedly connected to the secondary coil. A step-up transformer TM1 boosts a 380-V alternating current and changes it to direct current to charge a pulse capacitor C1 and store energy in the pulse capacitor C1. A discharge thyristor M3 is triggered, and the pulse capacitor C1 releases the energy instantaneously. A stress wave is generated between the primary coil and the secondary coil. The stress wave is transmitted to a fire extinguishing bomb through the stress wave amplifier, to launch the fire extinguishing bomb.

Abstract: A test system includes a transmitter, capacitor, and receiver. The transmitter includes: an output circuit coupled to the receiver via the capacitor; a transmitting circuit transmitting a predetermined signal to a pad of the output circuit during a first test; a signal generator outputting a first signal and second signal to the pad during a first process and second process of a second test; and a comparator comparing the pad's signal with a reference signal in the first process and second process to determine whether the second test passes. The receiver includes: an input circuit coupled to the transmitter via the capacitor; a switch coupled between the input circuit and a receiving circuit to be conducting in the first test and second process and nonconducting in the first process; and the receiving circuit determining whether the first test passes according to the predetermined signal and assisting the capacitor in discharging.

Abstract: A control mechanism of a vehicle-mounted system for electromagnetic launch of fire extinguishing bombs for high-rise buildings is provided. A stress wave amplifier is fixedly connected to a secondary coil, a primary coil is fixedly connected to a coil base, a guide shaft passes through a central hole in the primary coil and the coil base, and a head of the guide shaft is fixedly connected to the secondary coil. A step-up transformer TM1 boosts a 380-V alternating current and changes it to direct current to charge a pulse capacitor C1 and store energy in the pulse capacitor C1. A discharge thyristor M3 is triggered, and the pulse capacitor C1 releases the energy instantaneously. A stress wave is generated between the primary coil and the secondary coil. The stress wave is transmitted to a fire extinguishing bomb through the stress wave amplifier, to launch the fire extinguishing bomb.

Abstract: The present disclosure provides a crystal-less clock and data recovery (CDR) circuit and a frequency detection method thereof. The CDR circuit includes a clock generator and a frequency detection module. The clock generator is operable to generate a clock signal. The frequency detection module coupled to the clock generator is configured for outputting a control signal to the clock generator to increase or decrease the frequency of the clock signal according to a data signal received and a transition density.

Abstract: The present disclosure provides a crystal-less clock and data recovery (CDR) circuit and a frequency detection method thereof. The CDR circuit includes a clock generator and a frequency detection module. The clock generator is operable to generate a clock signal. The frequency detection module coupled to the clock generator is configured for outputting a control signal to the clock generator to increase or decrease the frequency of the clock signal according to a data signal received and a transition density.

Abstract: Methods, apparatus and electronic devices for moving a target element are provided herein. An exemplary method can be implemented on an electronic device having a display unit. The display unit can display a display interface. A selection signal can be received. A state of a target element on the display interface can be updated as a selected state according to the selection signal. A movement signal linked after the selection signal can be received. A notification message of a target location can be displayed following the movement signal on the display interface. A confirmation signal linked after the movement signal can be received. The target element can be moved to the target location based on the confirmation signal.

Abstract: The present invention is directed to methods and compositions for expanding and stabilizing the phenotype of natural regulatory T cells. In particular, the present invention provides methods and compositions for treating natural regulatory T cells that renders the cells resistant to factors present in the inflammatory milieu and stabilizes the suppressive properties of the cells.

Abstract: The present invention is directed to methods and compositions for expanding and stabilizing the phenotype of natural regulatory T cells. In particular, the present invention provides methods and compositions for treating natural regulatory T cells that renders the cells resistant to factors present in the inflammatory milieu and stabilizes the suppressive properties of the cells.

Abstract: Methods and apparatuses are provided for adapting hierarchical structure information associated with a first ranking function tuned for use in a first domain for use in a second domain.

Abstract: The present invention is directed to methods of identifying and enriching for viable Foxp3+ cells and the use of such cells. In particular, the present invention provides methods whereby viable Foxp3+ cells are isolated from a mixed population of cells; Foxp3+ cells being identifiable as those cells with relatively high forward scatter as assessed by a flow cytometer.

Abstract: A system for determining the intent of query that includes a search engine that receives a first search query, a query/click log module configured to store log data associated with the first search query; and a computational module that generates metric values associated with the first search query based on the log data and that determines that the first search query is one of a regional specific query or a global query based on the metric values, where the metric values reflect a likelihood of local intent of the first search query, and where the search engine provides search results selected in part based on the metric values.

Abstract: To estimate, or predict, the relevance of items, or documents, in a set of search results, relevance information is extracted from user click data, and relational information among the documents as manifested by an aggregation of user clicks is determined from the click data. A supervised approach uses judgment information, such as human judgment information, as part of the training data used to generate a relevance predictor model, which minimizes the inherent noisiness of the click data collected from a commercial search engine.

Abstract: Exemplary methods and apparatuses are provided which may be used to establish a ranking function or the like, which may be used by a search engine or other like tool to search a related-task search domain.

Abstract: Methods and apparatuses are provided for adapting hierarchical structure information associated with a first ranking function tuned for use in a first domain for use in a second domain.

Abstract: A system for determining the intent of query that includes a search engine that receives a first search query, a query/click log module configured to store log data associated with the first search query; and a computational module that generates metric values associated with the first search query based on the log data and that determines that the first search query is one of a regional specific query or a global query based on the metric values, where the metric values reflect a likelihood of local intent of the first search query, and where the search engine provides search results selected in part based on the metric values.

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).