Patents by Inventor Guobiao LIU

Guobiao LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF
    Publication number: 20240109890
    Abstract: Bridged heterocyclyl-substituted pyrimidine compounds, a preparation method and medical use thereof. The compounds or pharmaceutical compositions comprising same can be used as JAK1 and TYK2 kinase inhibitors for treating JAK1 and TYK2 kinase activity-related diseases such as inflammations, autoimmune diseases and cancers.
    Type: Application
    Filed: January 12, 2022
    Publication date: April 4, 2024
    Inventors: Huijun Yin, Xu Yan, Jizhou Shi, Guobiao Liu, Liuxin Dong, Mingzhao Shao
  • TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20240092744
    Abstract: A tricyclic compound having the structure represented by general formula (I), a pharmaceutical composition thereof, a preparation method therefor and the use thereof in the prevention and treatment of a variety of diseases caused by toxic aldehydes.
    Type: Application
    Filed: December 27, 2021
    Publication date: March 21, 2024
    Inventors: Huijun Yin, Xu Yan, Guobiao Liu, Jianxin Shi, Shizhu Chen
  • TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20230021669
    Abstract: Disclosed are a tricyclic compound as represented by general formula (I), a pharmaceutical composition containing same, and a preparation method therefor and the medical use thereof. The compound can be used for preventing and treating a variety of diseases caused by toxic aldehydes.
    Type: Application
    Filed: December 29, 2020
    Publication date: January 26, 2023
    Applicant: The National Institutes of Pharmaceutical R&D Co., Ltd.
    Inventors: Huijun YIN, Xu YAN, Guobiao LIU, Jianxin SHI, Shizhu CHEN, Siyang REN, Yadong FENG
  • BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
    Publication number: 20220348572
    Abstract: A bridged heterocyclyl-substituted pyrimidine compound, a preparation method therefor, and pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method for the compound, a pharmaceutical composition containing the compound, use of the compound as a JAK1 and TYK2 kinase inhibitor, and use in treating diseases related to JAK1 and TYK2 kinase activity, such as inflammations, autoimmune diseases, and cancers. The definition of each substituent in general formula (I) is the same as that in the description.
    Type: Application
    Filed: August 5, 2020
    Publication date: November 3, 2022
    Inventors: Huijun YIN, Xu YAN, Jizhou SHI, Guobiao LIU, Teng FEI, Liuxin DONG, Yuanye LIU