Abstract: An aqueous reagent solution includes a magnesium salt in a range of 30 mM to 500 mM, a potassium salt in a range of 0.8 M to 1.0 M, a buffering agent in a range of 150 mM to 500 mM, and a surfactant in a range of 0.05% to 0.5%.

Abstract: A diphenylaminopyrimidine and triazine compound of Formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate or solvate thereof is disclosed In formula I, A is C or N; X and Y are independently selected from hydrogen, halo, cyano, trifluoromethyl, alkoxy, alkyl, aryl, alkenyl, alkynyl and nitro; or X and Y, together with the atoms to which they are attached, form a phenyl or an heteroaromatic ring; R1 is R2 is CD3 or CD2CD3; R3 is R4 is hydrogen, methyl, trifluoromethyl, cyano or halo; R5 is hydrogen, alkyl, substituted and unsubstituted phenyl, allyl or propargyl; R6 and R7 are independently selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl and propargyl; or R6 and R7, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl group. The compound has pharmacodynamic and pharmacokinetic properties and ALK kinase inhibitory activity.

Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

Abstract: A network device and a vertical interface are disclosed. The network device includes a panel (31), a printed circuit board PCB (32), and N vertical interfaces (33). The vertical interface is an interface whose width is less than a height. The panel is connected to the PCB, and the panel includes N vertical openings, where N is greater than or equal to 2. Each of the N vertical interfaces includes a housing (331), a connection component (332), and a connector (333). The housing is configured to accommodate the vertical interface into the panel by using one of the N vertical openings on the panel. The connection component is configured to connect the vertical interface to the PCB. The connector is configured to transmit a signal to the PCB by using the connection component.

Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.

Abstract: The disclosure relates to systems and methods for magnetic resonance imaging (MRI). A method may include obtaining k-space data associated with MR signals acquired by an MR scanner. The k-space data may corresponding to a first sampling rate. The method may also include generating one or more estimated images based on the k-space data and a target neural network model. The one or more estimated images may correspond to a second sampling rate that exceeds the first sampling rate. The method may further include determining one or more target images based on the one or more estimated images and the k-space data using a compressed sensing model. The compressed sensing model may be constructed based on the one or more estimated images.

Abstract: The invention discloses a manufacturing process of a display screen cover, and a display screen. The manufacturing process includes the following steps: S1, providing a lamp panel provided with LED lamp beads; S2, arranging a glue barrier; S3, filling the hollow region of the glue barrier with glue I, and covering the LED lamp beads with the glue I; S4, providing a press plate; S5, curing the glue I; and S6, removing the press plate and the glue barrier. The cover does not need to be additionally assembled on the lamp panel, so that the lamp beads are protected against damage from the cover, and the yield of display screens is increased; and gaps between the lamp beads are completely filled with the cover, so that the lamp beads are fully protected.

Abstract: In some embodiments, the disclosure relates generally to methods as well as related compositions, systems, kits and apparatus comprising linking proteins to target compounds and/or to locations of interest using tethers. For example, the tether can be used to link the protein to a target compound, for example, to link an enzyme to a substrate. Similarly, the tether can be used to link the protein at or near a desired location on a surface. In one group of embodiments, the tether includes a polynucleotide and the target compound or location on the surface includes another polynucleotide that is capable of hybridizing to the tether. In such embodiments, the tether can be used to link the protein to the target compound or location using nucleic acid hybridization.

Abstract: A method of sequencing a nucleic acid strand includes receiving particles having nucleic acid strands coupled to a polymer matrix, exposing the particles to a solution including a condensing agent, and applying the particles to a surface, the particles depositing on the surface.

Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.

Abstract: An IGBT short-circuit detection and protection circuit, comprising: a driving unit, the output end thereof outputting a PWM driving signal and being connected to gate ends of a first IGBT (IGBT1) and a second IGBT (IGBT2), so as to simultaneously control the turning ON/OFF of the first IGBT and the second IGBT; a comparing unit, comprising a threshold pin and a detection pin (Vdesat), the threshold pin being connected to a threshold voltage, the detection pin being connected by means of a first diode (D1) and a second diode (D3) to collectors (C) of the first IGBT and the second IGBT, respectively, the detection pin supplying a detection current to the first diode and the second diode, cathodes of the first diode and the second diode being connected to the collectors of the first IGBT and the second IGBT, respectively; when the voltage at the detection pin is higher than the threshold voltage, the driving unit controlling the first IGBT and the second IGBT to be turned off.

Abstract: A system and method for magnetic resonance imaging is provided. The method includes dividing k-space into a plurality of regions along a dividing direction; scanning an object using a plurality of sampling sequences; acquiring a plurality of groups of data lines; filling the plurality of groups of data lines into the plurality of regions of the k-space; and reconstructing an image based on the filled k-space.

Abstract: A method for image reconstruction may include: obtaining a plurality of sets of scan data captured by a magnetic resonance imaging (MRI) device, each set of scan data corresponding to a same scanning area of an object and corresponding to a plurality of scanning characteristics; generating one or more shareable data sets based on the plurality of sets of scan data; generating, based on the one or more shareable data sets, at least one optimized data set for each of the plurality of scanning characteristics; and reconstructing, based on at least one optimized data set for at least one of the plurality of scanning characteristics, the plurality of sets of scan data to obtain a reconstructed image for the at least one scanning characteristic.

Abstract: A system and method for magnetic resonance imaging is provided. The method includes generating a main magnetic field through a region of interest (ROI), applying a slice selection gradient to an slice of the ROI, applying a plurality of RF pulses to the slice to generate a plurality of echoes, applying a first encoding gradient and a second encoding gradient on the echoes, and generating MR images based on the echoes.

Abstract: Systems and methods are provided for processing information of a meeting. An exemplary system may include a communication interface configured to receive meeting information obtained by a plurality of client devices. The meeting information may include multiple audio streams. The system may also include a memory and a processor. The processor may execute instructions stored on the memory to perform operations. The operations may include determining signal-to-noise-ratio (SNR) indicators associated with the audio streams. The operations may also include selecting, from the audio streams, a candidate audio stream based on the SNR indicators. The SNR indicator associated with the candidate audio stream may indicate that the candidate audio stream has a higher average SNR than that of a predetermined number of other audio streams. In addition, the operations may include generating an output data stream including at least a portion of the candidate audio stream.

Abstract: The present disclosure discloses a magnetic silicone watchband, including a first watchband and a second watchband corresponding matched to the first watchband. An arc-shaped watchband head is provided at one end of the first watchband and is connected to the second watchband. A semi-circular magnet is provided at an upper end of the watchband head. A rectangular hoop is provided at the end of the second watchband and is corresponding matched with the first watchband. A mesh-shaped metal mesh belt is provided in the interior of the second watchband, and the metal mesh belt is magnetically attracted to the magnet. The present disclosure installs a magnet on the watchband head of the first watchband and installs a metal mesh belt in the interior of the second watchband, thereby realizing the arbitrary adjustment of the connection size between the first watchband and the second watchband.

Abstract: Disclosed is a switching network synchronization method, which is applied to a first switching device. The method comprises: receiving a first suspected target ID; the first suspected target ID being an ID corresponding to a suspected target switching device determined by an access device connected to the first switching device according to a first identity number ID; receiving via the access device a second suspected target ID sent by a second switching device; the second suspected target ID being an ID corresponding to a suspected target switching device determined by the second switching device; determining a first target ID according to the first suspected target ID and the second suspected target ID; and the first target ID being an ID corresponding to a target switching device. Also disclosed is a first switching device, an access device and a storage medium.

Abstract: A system and method for calculating a flip angle schedule is provided. The technique includes selecting an initial condition, providing a function for calculating flip angles, calculating flip angles, assessing the flip angles, and repeating the calculation of the flip angles by adjusting the function until a desired flip angle schedule is obtained.

Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification.

Abstract: A diphenylaminopyrimidine and triazine compound of Formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate or solvate thereof is disclosed In formula I, A is C or N; X and Y are independently selected from hydrogen, halo, cyano, trifluoromethyl, alkoxy, alkyl, aryl, alkenyl, alkynyl and nitro; or X and Y, together with the atoms to which they are attached, form a phenyl or an heteroaromatic ring; R1 is R2 is CD3 or CD2CD3; R3 is R4 is hydrogen, methyl, trifluoromethyl, cyano or halo; R5 is hydrogen, alkyl, substituted and unsubstituted phenyl, allyl or propargyl; R6 and R7 are independently selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl and propargyl; or R6 and R7, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl group. The compound has pharmacodynamic and pharmacokinetic properties and ALK kinase inhibitory activity.