Patents by Inventor Guobin Ren

Guobin Ren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12286389
    Abstract: A crystalline form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide is provided. The crystalline form has good light stability, high temperature stability, and high humidity stability.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: April 29, 2025
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD
    Inventors: Guobin Ren, Dongxu Yi, Weijie Ji, Jiajun Huang
  • Patent number: 12268689
    Abstract: Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-K? radiation, eutectic form A has characteristic peaks represented by a 2? degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: April 8, 2025
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Patent number: 12122762
    Abstract: Provided is crystal form A of N,N?-(10,17-dioxo-3,6,21,24-tetraoxa-9,11,16, 18-tetrazohexahexane-1,26-di-yl)bis(4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl) benzene sulfonamide. The crystal form has good light stability, high-temperature stability, and high-humidity stability.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: October 22, 2024
    Assignee: SHENZHEN RENTAI PHARMATECH LTD.
    Inventors: Guobin Ren, Dongxu Yi, Jiajun Huang
  • Patent number: 12122804
    Abstract: A crystal form X of 3?-hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1?-yl)-19-nor-5?-pregnan-20-one, a preparation method of said crystal form and an application thereof in preparing a drug for treatment of central nervous system disease.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 22, 2024
    Assignee: SHENZHEN RENTAI PHARMATECH LTD.
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Patent number: 11414414
    Abstract: Provided are a pyrroloquinoline quinone glycine betaine salt and a crystalline form thereof. The pyrroloquinoline quinone glycine betaine salt has the advantages of high solubility, good stability, a simple preparation process and low solvent residue.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 16, 2022
    Assignee: SHANGHAI XUANCHUANG BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Guobin Ren, Jinyao Chen
  • Publication number: 20220169619
    Abstract: Disclosed is crystal form M of the proline hydroxylase inhibitor daprodustat, wherein the X-ray powder diffraction thereof, expressed in 2? angles and using Cu-Ka radiation, has characteristic peaks at 4.7±0.2°, 6.5±0.2°, and 6.8±0.2°. Disclosed are the preparation method for and the use of crystal form M. The crystal form M has good light stability, high temperature stability and high humidity stability, good solubility, and high purity.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220169658
    Abstract: Provided are a crystal form of a gonadotropin releasing hormone antagonist, a preparation method therefor, and use thereof. A crystal form C and a crystal form D have high purity, good illumination stability, high temperature stability, and high humidity stability, and have good solubility and low hygroscopicity; the saturation solubility of the crystal form C and the crystal form D is 101.75 ?g/ml and 87.21 ?g/ml, respectively; when the relative humidity is increased from 0 to 50% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 1.76% and 0.73%, respectively; and when the relative humidity is increased from 0 to 90% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 3.43% and 1.61%, respectively. Therefore, the control of a production condition is facilitated, the preparation process is simple, the quality is stable, and large-scale industrial production is easy.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220143019
    Abstract: Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-K? radiation, eutectic form A has characteristic peaks represented by a 20 degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220098230
    Abstract: A crystal form X of 3?-hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1?-yl)-19-nor-5?-pregnan-20-one, a preparation method of said crystal form and an application thereof in preparing a drug for treatment of central nervous system disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: March 31, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu YI, Jiajun Huang
  • Publication number: 20220033347
    Abstract: A crystalline form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide is provided. The crystalline form has good light stability, high temperature stability, and high humidity stability.
    Type: Application
    Filed: September 28, 2021
    Publication date: February 3, 2022
    Inventors: Guobin REN, Dongxu YI, Weijie JI, Jiajun HUANG
  • Publication number: 20220033355
    Abstract: A crystal form A of 2-(2, 5-dioxopyrrolidin-1yl)ethyl methyl fumarate has a good light irradiation stability, high-temperature stability and high-humidity stability.
    Type: Application
    Filed: September 28, 2021
    Publication date: February 3, 2022
    Inventors: Guobin REN, Dongxu YI, Weijie JI, Jiajun HUANG
  • Publication number: 20210403450
    Abstract: Provided is crystal form A of N, N?-(10, 17-dioxo-3, 6, 21, 24-tetraoxa-9, 11, 16, 18-tetrazohexahexane-1, 26-di-yl)bis(4-(6, 8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl) benzene sulfonamide. The crystal form has good light stability, high-temperature stability, and high-humidity stability.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Inventors: Guobin REN, Dongxu YI, Jiajun HUANG
  • Patent number: 11186552
    Abstract: A tebuconazole polymorph and a preparation method therefor are described. In particular, a polymorph of (RS)-1-(4-chloropheny)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl) pentan-3-ol, a preparation method therefor and use thereof are provided. The tebuconazole polymorph has a high purity and excellent crystallization properties, is stable under high humidity, high temperature and light conditions, has excellent solubility, and has high processing properties for formulations, high biological activities and good sterilization effects. The preparation method is simple, has stable processes, and can be implemented on a large scale. The polymorph can greatly improve the quality control and industrial application of tebuconazole-containing pesticides.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: November 30, 2021
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhong Li, Guobin Ren, Xiaoyong Xu, Minghui Qi, Jian Hu, Chengyu Gong
  • Patent number: 11014890
    Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 25, 2021
    Assignee: SHENZHEN RENTAI PHARMATECH LTD
    Inventors: Dongxu Yi, Guobin Ren, Jian Ma, Shuhao Wen, Peiyu Zhang, Yang Liu, Xuekun Shi, Jiajun Huang, Yanqi Zhang, Shigang Ruan, Mingjun Yang, Guangxu Sun
  • Publication number: 20210087152
    Abstract: A tebuconazole polymorph and a preparation method therefor are described. In particular, a polymorph of (RS)-1-(4-chloropheny)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl) pentan-3-ol, a preparation method therefor and use thereof are provided. The tebuconazole polymorph has a high purity and excellent crystallization properties, is stable under high humidity, high temperature and light conditions, has excellent solubility, and has high processing properties for formulations, high biological activities and good sterilization effects. The preparation method is simple, has stable processes, and can be implemented on a large scale. The polymorph can greatly improve the quality control and industrial application of tebuconazole-containing pesticides.
    Type: Application
    Filed: October 10, 2018
    Publication date: March 25, 2021
    Inventors: Zhong LI, Guobin REN, Xiaoyorig XU, Minghui QI, Jian HU, Chengyu GONG
  • Publication number: 20200385380
    Abstract: Provided are a pyrroloquinoline quinone glycine betaine salt and a crystalline form thereof. The pyrroloquinoline quinone glycine betaine salt has the advantages of high solubility, good stability, a simple preparation process and low solvent residue.
    Type: Application
    Filed: February 6, 2018
    Publication date: December 10, 2020
    Inventors: GUOBIN REN, JINYAO CHEN
  • Publication number: 20200002282
    Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
    Type: Application
    Filed: May 3, 2019
    Publication date: January 2, 2020
    Inventors: Dongxu YI, Guobin REN, Jian MA, Shuhao WEN, Peiyu ZHANG, Yang LIU, Xuekun SHI, Jiajun HUANG, Yanqi ZHANG, Shigang RUAN, Mingjun YANG, Guangxu SUN
  • Patent number: 9670245
    Abstract: Provided are several types of ginsenoside polymorphic substances and a method for preparing same. In particular, new crystal form A, crystal form B, crystal form C, crystal form E, crystal form F, crystal form I, crystal form K, crystal form L, crystal form M, crystal form N, and crystal form O are involved.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: June 6, 2017
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Guobin Ren, Changliang Dai, Jinyao Chen, Feng Chen, Minghui Qi, Wenming Zhu, Minghuang Hong, Hua Bai
  • Patent number: 9643992
    Abstract: Provided are ginsenoside C-K polymorphic forms and a method for preparing same. The ginsenoside C-K polymorphic forms are crystal form D and crystal form H.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: May 9, 2017
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Guobin Ren, Changliang Dai, Jinyao Chen, Feng Chen, Minghui Qi, Wenming Zhu, Minghuang Hong, Hua Bai
  • Publication number: 20150065699
    Abstract: Provided are several types of ginsenoside polymorphic substances and a method for preparing same. In particular, new crystal form A, crystal form B, crystal form C, crystal form E, crystal form F, crystal form I, crystal form K, crystal form L, crystal form M, crystal form N, and crystal form O are involved.
    Type: Application
    Filed: April 1, 2013
    Publication date: March 5, 2015
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Guobin Ren, Changliang Dai, Jinyao Chen, Feng Chen, Minghui Qi, Wenming Zhu, Minghuang Hong, Hua Bai