Abstract: The disclosure discloses a Saccharomyces cerevisiae lysate containing one or more cytokines, a preparation method therefor and an application thereof in cell-cultured meat, and belongs to the technical field of genetic engineering and cell-cultured meat. The disclosure provides a method for further increasing recombinant cytokine yields using the GRAS strain of S. cerevisiae recombinantly expressing a single cytokine or co-expressing a combination of cytokines through promoter optimization, knockout of endogenous protease in yeast, genome-integrated expression and other means. The yeast lysate may be directly used for muscle stem cell culture after the process such as filtration, sterilization, and cytokine concentration measurement, effectively promoting muscle stem cell proliferation. The disclosure avoids the complex purification process in the production of recombinant cytokines, reduces the cost of cytokine production, and provides new ideas for large-scale low-cost development of cell-cultured meat.

Abstract: The present invention relates to dental medical instruments, and specifically discloses an automatic grinding drill device for oral caries, including a mounting frame. Two retainers are arranged on the mounting frame, the bottom of the mounting frame is connected with a support plate through drive assemblies, a drill bit assembly is arranged at the bottom of the support plate, and a visual recognition module is also arranged on the support plate. The present invention has the advantage that the retainers keep a real-time relative static state with teeth of a patient during use, needing no frequent correction, so that operation steps are simplified.

Abstract: An electronic device including optical sensing with a concentric architecture and methods for operation thereof is disclosed. The concentric architecture can include light detector(s) arranged in a concentric manner around light emitter(s). In some examples, at least one light emitter can be located in the center of the device, and each light detector can be located the same separation distance from the light emitter. Each light detector can be arranged such that the separation distance from the centrally located light emitter can be greater than the separation distance from another light emitter. Examples of the disclosure further include a selective transparent layer overlaying the light detector(s). The selective transparent layer can include section(s) transparent to a first wavelength range and non-transparent to a second wavelength ranges. In some examples, the selective transparent layer can further include section(s) transparent to the second wavelength range.

Abstract: A LED dimming circuit, including a low-level-voltage generation module, a high-level-voltage generation module, a base-voltage generation module, and a dimming-signal generation module. By counting the high and low levels of a low-frequency PWM signal, high and low-level voltages with respect to time are obtained; a constant current source and a capacitor are used to convert high-frequency switching signals to a DC base voltage that is only related to the duty cycle of the low-frequency PWM signal. When the base voltage is greater than a predetermined voltage, the base voltage is output as the dimming signal; when the base voltage is less than the predetermined voltage, a new PWM signal is output as the dimming signal, whose magnitude is the same of that of the predetermined voltage, wherein the average values of the new PWM signal and the base voltage are the same.

Abstract: The present disclosure discloses a harmonic reducer with conjugate cycloidal profiles, including a circular spline, a flexspline, a wave generator and a flexible bearing. A profile of the circular spline and a profile of the flexspline are conjugate cycloidal profiles. The profile of the circular spline and the profile of the flexspline are formed by hypocycloids and epicycloids formed by two rolling circles around a pitch circle of the circular spline and a pitch circle of the flexspline under an engaging state respectively. A sum of radii of the first rolling circle and the second rolling circle is equal to a difference between radii of the pitch circle of the circular spline and the pitch circle of the flexspline under the engaging state. The wave generator is a biarc cam wave generator, a cam curve is an arc within an angle of contact in the long axis direction.

Abstract: A vehicle-mounted hydrogen supply method and device for hydrogen-rich smelting in a blast furnace or shaft furnace, combining steel plant hydrogen supply requirements with vehicle-mounted hydrogen supply technologies to construct a vehicle-mounted hydrogen supply system applied to hydrogen-rich smelting in a blast furnace or shaft furnace, thus providing an effective and reliable pathway for safe and stable hydrogen supply in a blast furnace or shaft furnace smelting process to perform hydrogen-rich smelting testing and production. Compared with a newly-built hydrogen plant, the invested construction cost is low, the operation flow is simple, the method and device are not limited by technical upgrading and transformation, and the flexibility is high. At the same time, two working long pipe vehicles and two pressure reducing system intake pipelines are used for solving the problem of continuous hydrogen supply required for hydrogen-rich smelting in a blast furnace.

Abstract: A method for piloting from bypass in a network based on a satellite load platform can unify the influence of distance change and Doppler frequency shift of satellite ground stations in the whole network, and realize accurate quasi synchronization between the clock of the whole network and the clock of the satellite. The method includes transmitting a pilot signal from bypass based on a satellite load platform in a satellite communication system, taking a spaceborne high stability timing clock source as a reference, and transmitting the pilot signal to all downlink beams to provide the pilot signal for all satellite stations covered by the satellite.

Abstract: A method for quasi-synchronous code division multiple access based on synchronization clock by piloting can make CDMA operate in quasi-synchronous conditions, so it is suitable for open wireless channels with relay nodes, such as satellite communication systems, and open wireless channels without relay nodes. The method includes: adopting a mode of CDMA spread spectrum transmission to share power resources to transmit signals at multiple transmitting stations in open wireless channels; adopting an external pilot signal to provide synchronization clock for the CDMA signals transmitted by multiple terminal stations in the open wireless channels, eliminating path delay differences from the multiple terminal stations to a relay node or receiving station, and making multi-channel CDMA signals received at the relay node or receiving station clock synchronized and phase aligned. The method can realize the quasi-synchronous reception of multi-channel CDMA signals.

Abstract: An electronic device may have an optical sensor such as an ambient light sensor for detecting ambient light. The ambient light sensor may include one or more photodetectors and light control layers disposed over the photodetectors. The light control layers may include light control structures forming concentric strips of opaque or light absorbing material. The light control layers may include one layer of light control structures, two layers of light control structures, or three or more layers of light control structures separated by one or more intervening transparent substrates. The electronic device may include associated control circuitry configured to compute angular information on the ambient light based on readings output from the one or more photodetectors.

Abstract: An electronic device including optical sensing with a concentric architecture and methods for operation thereof is disclosed. The concentric architecture can include light detector(s) arranged in a concentric manner around light emitter(s). In some examples, at least one light emitter can be located in the center of the device, and each light detector can be located the same separation distance from the light emitter. Each light detector can be arranged such that the separation distance from the centrally located light emitter can be greater than the separation distance from another light emitter. Examples of the disclosure further include a selective transparent layer overlaying the light detector(s). The selective transparent layer can include section(s) transparent to a first wavelength range and non-transparent to a second wavelength ranges. In some examples, the selective transparent layer can further include section(s) transparent to the second wavelength range.

Abstract: The present disclosure discloses a method for improving production of L-lactic acid (L-LA) by Saccharomyces cerevisiae based on regulation and control of ethanol metabolic flux, and belongs to the technical field of microorganisms. According to the present disclosure, acid-resistant Saccharomyces cerevisiae TJG16 is used as a production strain, an ethanol dehydrogenase gene adhA derived from Bacillus subtilis is introduced to promote conversion of ethanol into acetaldehyde, and a lactate aldolase gene BAL derived from Brucella sp. is introduced to promote synthesis of lactic acid from the acetaldehyde. Moreover, an acetaldehyde dehydrogenase gene ALD6 is knocked out to prevent synthesis of acetic acid from the acetaldehyde, a transcriptional regulatory factor encoding gene GAL80 for regulating and controlling galactose is knocked out, and lactate dehydrogenase LDH is integrated, so that the L-LA is finally increased.

Abstract: A LED dimming circuit, including a low-level-voltage generation module, a high-level-voltage generation module, a base-voltage generation module, and a dimming-signal generation module. By counting the high and low levels of a low-frequency PWM signal, high and low-level voltages with respect to time are obtained; a constant current source and a capacitor are used to convert high-frequency switching signals to a DC base voltage that is only related to the duty cycle of the low-frequency PWM signal. When the base voltage is greater than a predetermined voltage, the base voltage is output as the dimming signal; when the base voltage is less than the predetermined voltage, a new PWM signal is output as the dimming signal, whose magnitude is the same of that of the predetermined voltage, wherein the average values of the new PWM signal and the base voltage are the same.

Abstract: The invention discloses a recombinant Corynebacterium glutamicum for efficient synthesis of highly pure hyaluronic acid and oligosaccharides thereof, belonging to the technical field of bioengineering. The recombinant Corynebacterium glutamicum constructed in the present invention can produce hyaluronic acid with a yield up to 40 g/L, and a crude product purity of 95%. Addition of exogenous hyaluronic acid hydrolase and optimization of the fermentation conditions results in hyaluronic acid oligosaccharides with specific molecular weight, and can further improve the yield of hyaluronic acid to 72 g/L. The invention lays a solid foundation for the efficient synthesis of highly pure hyaluronic acid by microorganisms, and the constructed recombinant Corynebacterium glutamicum is suitable for industrial production and application.

Abstract: Heat pipes and vapor chambers that are components of a DIMM cooling assembly are described.

Abstract: The present disclosure provides a recombinant Bacillus subtilis for increasing the yield of menaquinone 7 (MK-7) and application thereof, and belongs to the field of genetic engineering. In the present disclosure, 14 recombinant strains BS1-BS14 are constructed through the modification of genes related to the biosynthetic pathway of MK-7 on a chromosome of Bacillus subtilis, wherein BS6-BS14 significantly increase the yield of the MK-7, reaching up to 33.5 mg/L, which is 3.53 times the yield of the original strain of wild-type Bacillus subtilis 168. The present disclosure further provides a method for modifying the MK-7 biosynthetic pathway in microorganisms to increase the yield of the MK-7, providing a theoretical basis for constructing a high-yielding strain of the MK-7.

Abstract: A compound represented by formula (I), or a stereoisomer, a tautomer, an isotope-labeled form, a nitrogen oxide, a solvate, a polymorph, a pharmaceutically acceptable salt, or a prodrug thereof, a method for preparing the same, and a pharmaceutical composition comprising the same are provided. The compound is a NK-3 receptor antagonist, and may be used for preventing and/or treating depression, anxiety disorder, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory disease, vomiting, preeclampsia, airway-related disease, reproductive disorder, contraception and sex hormone-dependent disease, gynecological disease-related disease, or menopausal syndrome-related disease.

Abstract: The present disclosure provides a method of determining a distance and a height, including: measuring, a first distance, a second distance and a third distance from the security inspection device to the tested person as well as measuring a first height, a second height and a third height of the tested person; determining, a relationship between the first distance and a minimum distance threshold as well as a maximum distance threshold, a relationship between the second distance and the minimum distance threshold as well as the maximum distance threshold, and a relationship between the third distance and the minimum distance threshold as well as the maximum distance threshold; determining, a final distance from the security inspection device to the tested person and a final height of the tested person; and performing a pixel conversion and a size conversion on the pupil image of the tested person.

Abstract: This relates to an electronic device configured for optical sensing having shared windows and including light restriction designs. The light restriction designs can include one or more of optical layers, optical films, lenses, and window systems configured to reduce or eliminate crosstalk between optical components. A plurality of accepting sections and a plurality of blocking sections can be employed to selectively allow light having an angle of incidence within one or more acceptance viewing angles and block light with angles of incidence outside of the acceptance viewing angles. In some examples, the light restriction designs can include variations in optical and structural properties can allow the light restriction designs to have spatially varying acceptance angles. Variations in structural properties can include, but are not limited to, differences in widths, heights, and/or tilts of the accepting sections and/or blocking sections.

Abstract: A compound of Formula I, or a racemate, a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, an N-oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or a pharmaceutically acceptable salt thereof are provided. Also provided is a pharmaceutical composition containing the compound of Formula I and derivatives, a preparation method therefor, and use thereof as a GHSR agonist in the preparation of drugs for diagnosing, preventing and/or treating growth hormone dependent disease.

Abstract: The present disclosure discloses a salt-reduced fermentation method for high-salt dilute-state fermented soy sauce, and belongs to the technical field of fermentation engineering. The present disclosure separates and screens Weissella paramesenteroides JL-5 and Bacillus amyloliquefaciens JDF-2 which inhibit the growth of spoilage bacteria from low-salt soy sauce mash, and by changing the microbial fermentation process of high-salt dilute-state soy sauce, the strains obtained by screening are used for the fermentation of low-salt soy sauce mash. Without changing the flavor and quality of soy sauce, low-salt fermentation of the soy sauce is enabled to proceed normally, and the biogenic amine content is less than 100 mg L?1, and the number of spoilage bacteria in the soy sauce are reduced. The prepared low-salt soy sauce has an amino acid nitrogen content of greater than 1.2 g·100 mL?1, contents of various spoilage bacteria of less than 1.