Abstract: The present disclosure provides methods and systems for processing samples including nucleic acid molecules. The methods may comprise identifying polymorphisms in a plurality of sequencing libraries and using the polymorphisms to identify the plurality of sequencing libraries as being associated with the same sample.

Abstract: The present disclosure provides methods and systems for processing nucleic acid molecules. The methods may comprise performing one or more extension or amplification processes to provide libraries for subsequent analysis using nucleic acid sequencing. Logical partitioning and directionality considerations may facilitate efficient and cost-effective amplification of target nucleic acid sequences.

Abstract: The disclosure provides methods and systems for sequencing long nucleic acid fragments. In one aspect, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences. Some embodiments of the methods, systems and reagent kits are particularly suitable for sequencing a large number of fragments, particularly long fragments.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences. Some embodiments of the methods, systems and reagent kits are particularly suitable for sequencing a large number of fragments, particularly long fragments.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences. Some embodiments of the methods, systems and reagent kits are particularly suitable for sequencing a large number of fragments, particularly long fragments. Some embodiments of the methods, systems and reagent kits are for native extension parallel sequencing of polynucleotide.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments.

Abstract: The present invention provides methods for native extension parallel sequencing of polynucleotide.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences. Some embodiments of the methods, systems and reagent kits are particularly suitable for sequencing a large number of fragments, particularly long fragments.

Abstract: The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments.

Abstract: The present invention provides methods and systems for sequencing long nucleic acid fragments.

Abstract: The present disclosure relates generally to a co-formulation or co-administration of acetaminophen with one or more chemicals that are metabolites or their derivatives in the methionine and glutathione biosynthesis pathways, for protection against acetaminophen-induced liver toxicity. The formulation may comprise acetaminophen and diet supplements such as S-methylmethionine (SMM). The present disclosure also encompasses methods of providing pain or fever relief with protection against acetaminophen-induced liver injury with the formulations described herein. Embodiments of the present disclosure also include co-formulation or co-administration of an agent and one or more other chemicals for reducing agent-induced liver toxicity via depletion of glutathione.

Abstract: A LED lamp and a manufacturing method thereof are disclosed. At least one blue LED chip can be used as an excitation light source. A number of red LED chips are arranged around the blue LED chip. The blue LED chip and red chips are covered with a packaging material with phosphor. The intensity of red light can be adjusted by a control circuit. Thus, the white LED lamps with high efficacy and high color rendering at different color temperatures can be achieved.

Abstract: The present invention provides methods for native extension parallel sequencing of polynucleotide.

Abstract: Systems and methods for aligning objects in object sets are provided. An object set has objects that are in a corresponding image in a plurality of images. For each respective object in a first object set, a corresponding object group is constructed that contains the respective object, thereby constructing a plurality of object groups. Similarity metrics are computed between object groups and objects in objects sets in order to assign the objects to object groups. The object groups are then refined in order to align objects in the object sets.

Abstract: Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.

Abstract: A LED lamp and a manufacturing method thereof are disclosed. At least one blue LED chip can be used as an excitation light source. A number of red LED chips are arranged around the blue LED chip. The blue LED chip and red chips are covered with a packaging material with phosphor. The intensity of red light can be adjusted by a control circuit. Thus, the white LED lamps with high efficacy and high color rendering at different color temperatures can be achieved.

Abstract: Computer systems, computer program products and methods for processing an input nucleic acid chromatogram having a plurality of substantially simultaneous traces. Each trace in the plurality of traces has a plurality of datapoints. Each respective datapoint in each of the plurality of datapoints represents a signal amplitude at a position in the trace corresponding to the respective datapoint. A first peak is identified in a first trace that is substantially overlapping a second peak in a second trace in the plurality of traces. The first peak is outputted to a first output homozygous representation and the second peak is outputted to a second output homozygous representation. The first output homozygous representation is a first homozygous sequence representation or a first homozygous nucleic acid chromatogram corresponding to the input nucleic acid chromatogram.

Abstract: Systems and methods for aligning objects in object sets are provided. An object set has objects that are in a corresponding image in a plurality of images. For each respective object in a first object set, a corresponding object group is constructed that contains the respective object, thereby constructing a plurality of object groups. Similarity metrics are computed between object groups and objects in objects sets in order to assign the objects to object groups. The object groups are then refined in order to align objects in the object sets.

Abstract: Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.