Patents by Inventor Guodong Chu

Guodong Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and intermediates for preparing lapatinib
    Patent number: 8563719
    Abstract: The present invention provides a process for making lapatinib and its pharmaceutically acceptable salt by use of new intermediates. A new process for obtaining a pharmaceutical form of lapatinib ditosylate monohydrate is also provided.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: October 22, 2013
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Yung-Fa Chen, Julian Paul Henschke, Yuanlian Liu, Guodong Chu, Xiaoheng Zhang
  • Process and Intermediates for Preparing Lapatinib
    Publication number: 20130005971
    Abstract: The present invention provides a process for making lapatinib and its pharmaceutically acceptable salt by use of new intermediates. A new process for obtaining a pharmaceutical form of lapatinib ditosylate monohydrate is also provided.
    Type: Application
    Filed: March 23, 2011
    Publication date: January 3, 2013
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Yung-Fa Chen, Julian Paul Henschke, Yuanlian Liu, Guodong Chu, Xiaoheng Zhang
  • PROCESS OF MAKING CLADRIBINE
    Publication number: 20120197010
    Abstract: A method of making cladribine with an increased purity comprising: a) dissolving crude cladribine in a protic solvent in the presence of a base to form a solution comprising dissolved crude cladribine; b) maintaining the solution at an elevated temperature so that the solution is homogeneous until the amount of protected or partially protected nucleoside impurities in the solution is reduced to a pre-determined upper limit; and c) cooling the solution of step b) so that crystals of cladribine are formed and isolated.
    Type: Application
    Filed: March 26, 2012
    Publication date: August 2, 2012
    Applicant: ScinoPharm (Kunshan) Biochemical Technology Co., Ltd.
    Inventors: Julian Paul HENSCHKE, Xiaoheng Zhang, Guodong Chu, Lijun Mei, Yung Fa Chen
  • Process for the preparation of cladribine
    Patent number: 8232387
    Abstract: A process for the preparation of cladribine of API grade is provided by direct coupling of O-protected 2-deoxy-ribofuranose with silylated 2-chloroadenine followed by deprotection of the resultant protected nucleoside in a separate step and then a purification step. Following the coupling, the desired N-9-glycosylated ?-anomer of the nucleoside is directly isolated as a solid from the coupling reaction mixture by filtration in relatively high purity and yield, and it does not require purification.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: July 31, 2012
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Julian Paul Henschke, Xiaoheng Zhang, Guodong Chu, Lijun Mei, Yung Fa Chen
  • Process for the Preparation of Cladribine
    Publication number: 20110046363
    Abstract: A process for the preparation of cladribine of API grade is provided by direct coupling of O-protected 2-deoxy-ribofuranose with silylated 2-chloroadenine followed by deprotection of the resultant protected nucleoside in a separate step and then a purification step. Following the coupling, the desired N-9-glycosylated ?-anomer of the nucleoside is directly isolated as a solid from the coupling reaction mixture by filtration in relatively high purity and yield, and it does not require purification.
    Type: Application
    Filed: August 17, 2010
    Publication date: February 24, 2011
    Inventors: Julian Paul Henschke, Xiaoheng Zhang, Guodong Chu, Lijun Mei, Yung Fa Chen