Abstract: Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs).

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one linear actuator has a moving portion that moves in a vertical direction to cause the at least one support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: A method of detecting maintenance requirements of a system for conveying a car through a passageway is provided. The method comprising: detecting pressure data for at least one or more locations along a passageway using a pressure sensor; comparing the pressure data to benchmark pressure data for each of the one or more locations; determining a pressure data variance at a first location of the one or more locations in response to the pressure data and the benchmark pressure data; and identifying an identity of a car stop location door system located at the first location when the pressure data variance is greater than a selected tolerance.

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one linear actuator has a moving portion that moves in a vertical direction to cause the at least one support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one linear actuator has a moving portion that moves in a vertical direction to cause the at least one support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one actuator arm has a portion configured to be contacted by a door of the elevator car to cause movement of the actuator arm relative to the mounting bracket as the door moves into an open position. The movement of the actuator arm causes the support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: A selectively operable magnetic braking system having a safety brake adapted to arrest movement when moved from a non-braking state into a braking state, a magnetic brake pad configured to move between an engaging position and a non-engaging position, the magnetic brake pad, when in the engaging position, moving an engaging mechanism and thereby the safety brake from the non-braking state into the braking state, and an electromagnetic actuator configured to move the magnetic brake pad from the non-engaging position to an engaging position.

Abstract: The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.

Abstract: A method of testing of an elevator safety brake system is provided. The method includes initiating an automated test procedure. The method also includes triggering an electronic safety actuator. The method further includes generating braking data about performance of the electronic safety actuator. The method yet further includes analyzing the braking data. The method also includes generating a report to indicate whether the elevator safety brake system performed adequately.

Abstract: A method of testing of an elevator safety brake system is provided. The method includes initiating an automated test procedure. The method also includes triggering an electronic safety actuator. The method further includes generating braking data about performance of the electronic safety actuator. The method yet further includes analyzing the braking data. The method also includes generating a report to indicate whether the elevator safety brake system performed adequately.

Abstract: A method of monitoring vibratory signatures of an elevator car is provided. The method comprising: detecting at least one vibratory signature of an elevator car, the vibratory signature comprising: a first vibratory signature in a first direction; and determining a probable cause of the at least one vibratory signature by comparing the at least one vibratory signature to a known vibratory signature.

Abstract: The present disclosure relates generally to a selectively operable safety brake including a magnetic brake operably coupled to a rod and disposed adjacent to a metal component, the magnetic brake configured to move between an engaging position and a non-engaging position, said magnetic brake, when in the engaging position contemporaneously with motion of the machine, moving the rod in to thereby move the safety brake from the non-braking state into the braking state, and an electromagnetic component including a retention apparatus, the electromagnetic component configured to move the magnetic brake from the engaging position to the non-engaging position upon receipt of a resetting signal.

Abstract: A brake member actuation mechanism for a safety brake member of a hoisted structure includes a brake actuator (12) formed of a ferro-magnetic material configured to be electronically actuated to magnetically engage a guide rail (14) upon detection of the hoisted structure exhibiting a predetermined condition, wherein the magnetic engagement of the brake actuator and the guide rail actuates movement of the safety brake member into a braking position.

Abstract: A selectively operable braking device for an elevator system. The braking device includes a safety brake adapted to be wedged against a guide rail when moved from a non-braking state into a braking state. Also included is an engagement mechanism moveable between an engaged position and a non-engaged position, the engagement mechanism comprising bar pinions each having teeth and connected to at least one of the other bar pinions with a meshed engagement of the teeth, the engagement mechanism configured to move the safety brake between the non-braking state and braking state when the engagement mechanism moves between the non-engaged position and the engaged position. Further included is a plurality of magnetic brake pads, each of the brake pads coupled to one of the bar pinions, wherein movement of one of the brake pads into the engaged position causes movement of the other magnetic brake pads into the engaged position.

Abstract: An elevator system including an elevator car frame including an interior side, a service panel operably coupled to the interior side of the elevator car frame, the service panel including a panel interior side and a panel exterior side, and configured to operate between an open and closed position, an elevator car operably coupled to the elevator car frame, the elevator car including an interior cavity, wherein the panel exterior side is disposed within the interior cavity when the service panel is in an open position.

Abstract: A braking system resetting mechanism for a hoisted structure includes a guide rail (14) and a brake member (10). Also included is a brake member actuation mechanism (12) operatively coupled to the brake member and configured to magnetically engage the guide rail to actuate the brake member from a non-braking position to a braking position. Further included is an outer structure having a slot (64) configured to guide the brake member actuation mechanism, wherein the slot includes a first angled region and a second angled region that intersect at an outer location. Also included is a spring loaded lever (202) operatively coupled to the outer structure and configured to engage the brake member actuation mechanism during a resetting operation, wherein the spring loaded lever biases the brake member actuation mechanism toward the outer location of the slot of the outer structure to disengage the brake member actuation mechanism from the guide rail.

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one actuator arm has a portion configured to be contacted by a door of the elevator car to cause movement of the actuator arm relative to the mounting bracket as the door moves into an open position. The movement of the actuator arm causes the support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: An illustrative example elevator sill assembly includes a sill plate and at least one support arm secured to the sill plate. A mounting bracket is configured to be mounted to an elevator car. The support arm is supported on the mounting bracket to allow the support arm to pivot relative to the mounting bracket. At least one linear actuator has a moving portion that moves in a vertical direction to cause the at least one support arm to pivot relative to the mounting bracket to thereby cause the sill plate to pivot from a stored position to an actuated position.

Abstract: The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.

Abstract: An elevator system including a hoistway, an elevator component disposed in the hoistway, a power generating device disposed within the hoistway and operably coupled to the elevator component, wherein the power generating device is configured to generate power when the elevator component is in motion.