Patents by Inventor Guohua Pan

Guohua Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
    Patent number: 8765748
    Abstract: The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: July 1, 2014
    Assignee: University Health Network
    Inventors: Heinz W. Pauls, Bryan T. Forrest, Radoslaw Laufer, Miklos Feher, Peter Brent Sampson, Guohua Pan, Sze-Wan Li, Yong Liu
  • METHODS OF INHIBITING TUMOR GROWTH USING TTK ANTAGONISTS
    Publication number: 20140086938
    Abstract: The present invention relates to methods for treating TTK positive breast cancers or soft-tissue sarcomas in a mammalian subject by administering a therapeutically effective amount of a TTK antagonist. The invention also provides compositions comprising a TTK antagonist and a HER-2 antagonist, as well as methods of diagnosing a basal-like breast cancer and methods of determining the prognosis of a subject having a cancer by assessing expression of TTK in a tumor sample from a subject.
    Type: Application
    Filed: July 19, 2013
    Publication date: March 27, 2014
    Applicant: University Health Network
    Inventor: Guohua Pan
  • Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
    Patent number: 8680282
    Abstract: A CPT1 inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: March 25, 2014
    Assignee: University Health Network
    Inventors: Heinz W. Pauls, Bryan T. Forrest, Peter Brent Sampson, Yong Liu, Radoslaw Laufer, Yunhui Lang, Miklos Feher, Yi Yao, Guohua Pan
  • KINASE INHIBITORS AND METHOD OF TREATING CANCER
    Publication number: 20140045838
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Application
    Filed: July 3, 2013
    Publication date: February 13, 2014
    Inventors: Peter Brent Sampson, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Radoslaw Laufer, Guohua Pan
  • KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
    Publication number: 20140045822
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Application
    Filed: July 3, 2013
    Publication date: February 13, 2014
    Applicant: UNIVERSITY HEALTH NETWORK
    Inventors: Peter Brent Sampson, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Guohua Pan
  • Methods of inhibiting tumor growth using TTK antagonists
    Patent number: 8492356
    Abstract: The present invention relates to methods for treating TTK positive breast cancers or soft-tissue sarcomas in a mammalian subject by administering a therapeutically effective amount of a TTK antagonist. The invention also provides compositions comprising a TTK antagonist and a HER-2 antagonist, as well as methods of diagnosing a basal-like breast cancer and methods of determining the prognosis of a subject having a cancer by assessing expression of TTK in a tumor sample from a subject.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: July 23, 2013
    Assignee: University Health Network
    Inventor: Guohua Pan
  • Kinase inhibitors and method of treating cancer with same
    Patent number: 8481525
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 9, 2013
    Assignee: University of Health Network
    Inventors: Peter Brent Sampson, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Guohua Pan
  • Kinase inhibitors and method of treating cancer
    Patent number: 8481533
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: July 9, 2013
    Assignee: University Health Network
    Inventors: Peter B. Sampson, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Radoslaw Laufer, Guohua Pan
  • METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR
    Publication number: 20130123273
    Abstract: Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.
    Type: Application
    Filed: July 4, 2011
    Publication date: May 16, 2013
    Applicant: UNIVERSITY HEALTH NETWORK
    Inventors: Guohua Pan, Jacqueline M. Mason, Xin Wei, Miklos Feher
  • Inhibitors of carnitine palmitoyltransferase and treating cancer
    Patent number: 8410150
    Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: April 2, 2013
    Assignee: University Health Network
    Inventors: Heinz W. Pauls, Peter Brent Sampson, Bryan T. Forrest, Radoslaw Laufer, Yong Liu, Miklos Feher, Yi Yao, Guohua Pan
  • KINASE INHIBITORS AND METHOD OF TREATING CANCER
    Publication number: 20120264800
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Application
    Filed: June 21, 2012
    Publication date: October 18, 2012
    Applicant: UNIVERSITY HEALTH NETWORKS
    Inventors: Peter Brent SAMPSON, Yong LIU, Sze-Wan LI, Bryan T. FORREST, Heinz W. PAULS, Louise G. EDWARDS, Miklos FEHER, Narendra Kumar B. PATEL, Radoslaw LAUFER, Guohua PAN
  • Liquid dispensing hair removal kit
    Patent number: 8220156
    Abstract: A hair removal kit having a handle, a cover removably engagable to the handle, and a cartridge removably engagable to the handle. The cartridge has at least one blade. A removable dispensing unit is disposed within the handle. The dispensing unit has a pump, an applicator in liquid communication with the pump, and a reservoir having a first position and a second position. The reservoir is in liquid communication with the pump in the second position, but not in liquid communication with the pump in the first position.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: July 17, 2012
    Assignee: The Gillette Company
    Inventors: Edward Neill Forsdike, Paul Michael Jessemey, Barry Keith Rockell, Kevin James Wain, Lee Burrowes, Guohua Pan
  • KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
    Publication number: 20120149686
    Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
    Type: Application
    Filed: April 6, 2010
    Publication date: June 14, 2012
    Applicant: University Health Networks
    Inventors: Peter B. Sampson, Yong liu, Sze-Wan Le, Brian T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Guohua Pan
  • Shaving razor handle
    Patent number: D660516
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: May 22, 2012
    Assignee: The Gillette Company
    Inventors: Vanessa Christie, Guohua Pan
  • Shaving cartridge connector
    Patent number: D661427
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: June 5, 2012
    Assignee: The Gillette Company
    Inventors: Vanessa Christie, Guohua Pan, Kevin James Wain, Xiaolan Xu
  • Package card for a personal care product
    Patent number: D661585
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: June 12, 2012
    Assignee: The Gillette Company
    Inventors: James Joseph Anderson, Carl Andrew Gerhards, Andrew A. Markle, Guohua Pan
  • Package card for a personal care product
    Patent number: D662418
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: June 26, 2012
    Assignee: The Gillette Company
    Inventors: James Joseph Anderson, Carl Andrew Gerhards, Andrew A. Markle, Guohua Pan
  • Shaving cartridge connector
    Patent number: D664712
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: July 31, 2012
    Assignee: The Gillette Company
    Inventors: Vanessa Christie, Guohua Pan, Kevin James Wain, Xiaolan Xu
  • Shaving cartridge connector
    Patent number: D664713
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: July 31, 2012
    Assignee: The Gillette Company
    Inventors: Vanessa Christie, Guohua Pan, Kevin James Wain, Xiaolan Xu
  • Travel case for a shaving razor
    Patent number: D681938
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: May 14, 2013
    Assignee: The Gillette Company
    Inventor: Guohua Pan