Abstract: A nitrogen-branched non-linear PEGylated lipid of Formula (1), wherein, X is —CRa< or (Ra is H or a C1-12 alkyl group); B1 and B2 are linking bonds or C1-20 alkylene groups; L1 and L2 are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ld is a linking bond or a divalent linking group; Ncore is a multivalent group of valence y+1, and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; Lx is a linking bond or a divalent linking group; XPEG is a polyethylene glycol component. The non-linear PEGylated lipid herein can realize better surface modification of LNP. The lipid nanoparticle pharmaceutical composition and its formulation exhibit higher drug efficacy, especially for nucleic acid drugs.

Abstract: In some examples, a device may include a backlight unit configured to illuminate a display. In some examples, a light source may direct light into an active photonic circuit. The active photonic circuit may include optical switches controllable to distribute the light to illuminate display zones. An active photonic circuit may include an arrangement of optical switches configured to allow particular zones to be raster scanned, for example, using light distribution and outcoupling further using a passive photonic circuit. The illumination intensity for each zone may be controlled using the optical switches and/or with variation of the light source intensity. In some examples, the illumination intensity for each zone can be varied based on the displayed content, allowing improved contrast ratios. In some examples, all zones may be illuminated simultaneously with a zonal illumination intensity based on displayed content. Other devices, methods, systems, and computer-readable media are also disclosed.

Abstract: An illumination module includes a LCoS panel, a plurality of light sources configured to generate illuminating light, and a lightguide optically coupled via coupling optics to the plurality of light sources and adapted to direct the illuminating light to the LCoS panel, the lightguide being configured to transmit light of a first polarization state and reflect light of a second polarization state orthogonal to the first polarization state. The plurality of light sources may include a microLED array.

Abstract: The disclosed method may include receiving laser light from a laser light source. The method may also include directing and distributing the laser light onto a laser-based panel display to render pixels having a reduced spatial coherence and a preserved pixel pitch. For example, the pixels may be rendered as a result of an optical path distance between the pixels being greater than a coherent length of the laser light. Alternatively or additionally, the pixels may be rendered as a result of incoherent addition of light from at least one of multiple ports or multiple sources. Alternatively or additionally, the pixels may be rendered as a result of active modulation of the laser light. Alternatively or additionally, the pixels may be rendered as a result of quasi-random placement of outcoupling elements. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed method may include configuring an illuminator to emit a first path of light in a first direction and to emit a second path of light in a second direction. The method may additionally include, configuring a reflector to reflect the first path of light in the second direction. The method may also include configuring the first path of light reflected in the second direction to interfere destructively with the second path of light when a liquid crystal is set to an off state. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A display system may include a display element having an array of pixels, at least one light source, and a photonic integrated circuit (PIC) illumination element overlapping the display element. The PIC illumination element may include at least one in-coupler for in-coupling light from the at least one light source and an array of out-coupling emitters configured to emit light from the PIC illumination element toward the display element. The array of out-coupling emitters may not be aligned pixel-by-pixel with the array of pixels. Various other devices, systems, and methods are also disclosed.

Abstract: Outcoupling elements are disposed with a transparent layer. A transparent waveguide structure receives non-visible light and delivers the non-visible light to the outcoupling elements. The outcoupling elements outcouple the non-visible light as non-visible illumination light.

Abstract: A system comprising (1) at least one optical element having a nonplanar surface, (2) at least one photonic integrated circuit disposed on the nonplanar surface of the optical element, the photonic integrated circuit comprising (A) an optical core that contains an optically anisotropic organic material and (B) a cladding disposed over the optical core. Various other apparatuses, systems, and methods are also disclosed.

Abstract: A display waveguide is configured to direct a first portion of display light to an eye along a first optical path. A disparity waveguide is configured to direct a second portion of the display light to a disparity sense circuit along a second optical path separated from the first optical path.

Abstract: A near-eye optical assembly includes a display waveguide and an optical structure. The display waveguide is configured to receive display light and to direct the display light to an eye of a user. The optical structure includes an input coupler, an optical path, and an output coupler. The input coupler is disposed to receive a portion of the display light that propagates through the waveguide. The optical path directs the portion of the display light from the input coupler to an output coupler that is configured to provide the received portion of the display light to a disparity sense circuit.

Abstract: A near-eye optical assembly includes a display waveguide and an optical structure. The display waveguide is configured to receive display light and to direct the display light to an eye of a user. The optical structure includes an input coupler, an optical path, and an output coupler. The input coupler is disposed to receive a portion of the display light that propagates through the waveguide. The optical path directs the portion of the display light from the input coupler to an output coupler that is configured to provide the received portion of the display light to a disparity sense circuit.

Abstract: An optical system is configured to support eye tracking operations in a head mounted device. The optical system includes a transparent layer, a laser, and first and second output couplers. The laser is configured to emit light into the transparent layer. The first output coupler is configured to out-couple a first portion of the light from a first location of the transparent layer. The second output coupler is configured to out-couple a second portion of the light from a second location of the transparent layer. The first and second output couplers are in the field-of-view of a user. A combination of the first portion of the light and the second portion of the light out-coupled from the first output coupler and the second output coupler is configured to generate a fringe pattern, for example, on an eye of a user of the head mounted device.

Abstract: There is provided a photonic integrated circuit configured for low-coherence interferometry and in-field sensing. The photonic integrated circuit can include an opto-coupler that has a substrate substantially transparent to a specified wavelength of light and a waveguide configured to route a light beam having a center wavelength at the specified wavelength. The opto-coupler further includes a mirror disposed at an angle, and the mirror is disposed on an angled surface of the substrate, the angled surface being proximate to an output end of the waveguide. The opto-coupler further includes a beam forming element configured to collect light reflected from the mirror, and the waveguide and the mirror are integrated within the substrate.

Abstract: The disclosed tunable laser array may include multiple lasers including at least first and second lasers having center emission wavelengths that are separated by at least a specified minimum wavelength. The tunable laser array may also include at least one coupler/splitter. In the tunable laser array, emitted light from the first laser at a first wavelength and emitted light from the second laser at a second, different wavelength may be combined and then split at the coupler/splitter. Moreover, the lasers may have at least a minimum amount of thermal resistance. Various other systems, apparatuses, and methods of manufacturing are also disclosed.

Abstract: A head-mounted display device includes a display panel positioned to provide an image toward an eye of a wearer of the head-mounted display device; one or more light sources positioned to provide illumination light toward a head of the wearer; and one or more light detectors for receiving a portion of the illumination light that has been scattered by the head of the wearer so that one or more characteristics associated with a blood flow in the head of the wearer are determined based on the received portion of the illumination light. A method of determining one or more characteristics associated with a blood flow in a head of a wearer of the head-mounted display device is also described.

Abstract: An example device may include a light source, an optical element, and, optionally, an encapsulant layer. A light beam generated by the light source may be received by the optical element and redirected towards an illumination target, such as an eye of a user. The optical element may include a material, for example, with a refractive index of at least approximately 2 at a wavelength of the light beam. The light source may be a semiconductor light source, such as a light-emitting diode or a laser. The optical element may be supported by an emissive surface of the light source. Refraction at an exit surface of the optical element, and/or within a metamaterial layer, may advantageously modify the beam properties, for example, in relation to illuminating a target. In some examples, the light source and optical element may be integrated into a monolithic light source module.

Abstract: A device includes a light source, a waveguide layer, and a light director layer. The light source emits illumination light. The waveguide layer includes a cladding layer and an optical waveguide. The cladding layer provides a top planar surface of the waveguide layer and the optical waveguide is immersed in the cladding layer and includes a light input coupler. The light director layer includes a bottom planar surface that is disposed on the top planar surface of the waveguide layer. The light director layer also includes a light director that receives and directs the illumination light to the light input coupler as shaped light. The light director is configured to tilt the illumination light to give the shaped light a tilt angle with respect to the light input coupler.

Abstract: Outcoupling elements are disposed with a transparent layer. A transparent waveguide structure receives non-visible light and delivers the non-visible light to the outcoupling elements. The outcoupling elements outcouple the non-visible light as non-visible illumination light.

Abstract: An optical element includes a transparent layer, outcoupling elements, and a waveguide structure. The outcoupling elements are positioned across the transparent layer. The waveguide structure provides non-visible light to the outcoupling elements and the outcoupling elements outcouple the non-visible light as non-visible illumination light to illuminate an eye region.

Abstract: A device includes a light source, a waveguide layer, and a light director layer. The light source emits illumination light. The waveguide layer includes a cladding layer and an optical waveguide. The cladding layer provides a top planar surface of the waveguide layer and the optical waveguide is immersed in the cladding layer and includes a light input coupler. The light director layer includes a bottom planar surface that is disposed on the top planar surface of the waveguide layer. The light director layer also includes a light director that receives and directs the illumination light to the light input coupler as shaped light. The light director is configured to tilt the illumination light to give the shaped light a tilt angle with respect to the light input coupler.